Essential thrombocythemia with myelofibrosis transformed into acute myeloid leukemia with der(1;15)(q10;q10): case report and literature review
Abstract Translocations involving chromosomes 1 and 15 are uncommon in hematologic malignancies. So far, only 42 cases have been reported with t(1;15) as a reciprocal or complex chromosomal abnormalities. We herein report the first case in the literature, to our knowledge, of a 44-year-old female wi...
Gespeichert in:
| Veröffentlicht in: | Cancer genetics and cytogenetics 2010-07, Vol.200 (1), p.28-33 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 33 |
|---|---|
| container_issue | 1 |
| container_start_page | 28 |
| container_title | Cancer genetics and cytogenetics |
| container_volume | 200 |
| creator | Charafeddine, Khalil M Mahfouz, Rami A Zaatari, Ghazi S Ibrahim, Georges Y Muwakkit, Samar A Najm, Nada D Farra, Chantal G |
| description | Abstract Translocations involving chromosomes 1 and 15 are uncommon in hematologic malignancies. So far, only 42 cases have been reported with t(1;15) as a reciprocal or complex chromosomal abnormalities. We herein report the first case in the literature, to our knowledge, of a 44-year-old female with essential thrombocythemia and severe myelofibrosis who developed acute myeloid leukemia (AML-M4) with der(1;15)(q10;q10) after 13 years of treatment. In addition, we reviewed the literature for all up-to-date published cases with t(1;15). |
| doi_str_mv | 10.1016/j.cancergencyto.2010.03.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754869628</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165460810001433</els_id><sourcerecordid>754869628</sourcerecordid><originalsourceid>FETCH-LOGICAL-c469t-d99c12085a2d0ba44de02d126e82e02533b9e9165040d9897e60fb7a1447ef243</originalsourceid><addsrcrecordid>eNqNUsuKFDEUDaI4besvSMCFM4tqbx71smFAhvYBAy7UdUglt-z0VFV6kpRDf4W_bJoeFd3oItxwc8655JxLyAsGKwaserVbGT0ZDF9xMofkVxzyC4hVLg_IgjW1KKQsq4dkkdFlIStozsiTGHcAUPO2ekzOOJRMlIItyPdNjDglpweatsGPnc-aWxydpncubel4wMH3rgs-ukhT0FPsfRjRUjclT7WZE55AztIB55vfVIvhnK1ZeXF-y2Cdz8VranREGnDvQ6J6ygyXMOg0h2P3m8O7p-RRr4eIz-7rknx5u_l89b64_vjuw9Wb68LIqk2FbVvDODSl5hY6LaVF4JbxChueb6UQXYtt_j5IsG3T1lhB39WaSVljz6VYkpcn3X3wtzPGpEYXDQ6DntDPUdWlbKq24s2_kUIwUUEeuSTrE9Jkt2LAXu2DG3U4KAbqGJ3aqT-iU8foFAiVS2Y_v58zd9nfX9yfWWXA5gTA7Ev2KqhoXBZC6wKapKx3_zno8i8dM7jJGT3c4AHjzs9hytYrpiJXoD4dt-i4RCzvD5NCiB_72sfO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733136053</pqid></control><display><type>article</type><title>Essential thrombocythemia with myelofibrosis transformed into acute myeloid leukemia with der(1;15)(q10;q10): case report and literature review</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Charafeddine, Khalil M ; Mahfouz, Rami A ; Zaatari, Ghazi S ; Ibrahim, Georges Y ; Muwakkit, Samar A ; Najm, Nada D ; Farra, Chantal G</creator><creatorcontrib>Charafeddine, Khalil M ; Mahfouz, Rami A ; Zaatari, Ghazi S ; Ibrahim, Georges Y ; Muwakkit, Samar A ; Najm, Nada D ; Farra, Chantal G</creatorcontrib><description>Abstract Translocations involving chromosomes 1 and 15 are uncommon in hematologic malignancies. So far, only 42 cases have been reported with t(1;15) as a reciprocal or complex chromosomal abnormalities. We herein report the first case in the literature, to our knowledge, of a 44-year-old female with essential thrombocythemia and severe myelofibrosis who developed acute myeloid leukemia (AML-M4) with der(1;15)(q10;q10) after 13 years of treatment. In addition, we reviewed the literature for all up-to-date published cases with t(1;15).</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/j.cancergencyto.2010.03.010</identifier><identifier>PMID: 20513531</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Chromosome Aberrations ; Chromosomes, Human, Pair 11 ; Chromosomes, Human, Pair 15 ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Leukemia, Myeloid, Acute - genetics ; Medical Education ; Primary Myelofibrosis - genetics ; Thrombocythemia, Essential - genetics</subject><ispartof>Cancer genetics and cytogenetics, 2010-07, Vol.200 (1), p.28-33</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>2010 Elsevier Inc. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-d99c12085a2d0ba44de02d126e82e02533b9e9165040d9897e60fb7a1447ef243</citedby><cites>FETCH-LOGICAL-c469t-d99c12085a2d0ba44de02d126e82e02533b9e9165040d9897e60fb7a1447ef243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cancergencyto.2010.03.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20513531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Charafeddine, Khalil M</creatorcontrib><creatorcontrib>Mahfouz, Rami A</creatorcontrib><creatorcontrib>Zaatari, Ghazi S</creatorcontrib><creatorcontrib>Ibrahim, Georges Y</creatorcontrib><creatorcontrib>Muwakkit, Samar A</creatorcontrib><creatorcontrib>Najm, Nada D</creatorcontrib><creatorcontrib>Farra, Chantal G</creatorcontrib><title>Essential thrombocythemia with myelofibrosis transformed into acute myeloid leukemia with der(1;15)(q10;q10): case report and literature review</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>Abstract Translocations involving chromosomes 1 and 15 are uncommon in hematologic malignancies. So far, only 42 cases have been reported with t(1;15) as a reciprocal or complex chromosomal abnormalities. We herein report the first case in the literature, to our knowledge, of a 44-year-old female with essential thrombocythemia and severe myelofibrosis who developed acute myeloid leukemia (AML-M4) with der(1;15)(q10;q10) after 13 years of treatment. In addition, we reviewed the literature for all up-to-date published cases with t(1;15).</description><subject>Adult</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, Pair 11</subject><subject>Chromosomes, Human, Pair 15</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Medical Education</subject><subject>Primary Myelofibrosis - genetics</subject><subject>Thrombocythemia, Essential - genetics</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsuKFDEUDaI4besvSMCFM4tqbx71smFAhvYBAy7UdUglt-z0VFV6kpRDf4W_bJoeFd3oItxwc8655JxLyAsGKwaserVbGT0ZDF9xMofkVxzyC4hVLg_IgjW1KKQsq4dkkdFlIStozsiTGHcAUPO2ekzOOJRMlIItyPdNjDglpweatsGPnc-aWxydpncubel4wMH3rgs-ukhT0FPsfRjRUjclT7WZE55AztIB55vfVIvhnK1ZeXF-y2Cdz8VranREGnDvQ6J6ygyXMOg0h2P3m8O7p-RRr4eIz-7rknx5u_l89b64_vjuw9Wb68LIqk2FbVvDODSl5hY6LaVF4JbxChueb6UQXYtt_j5IsG3T1lhB39WaSVljz6VYkpcn3X3wtzPGpEYXDQ6DntDPUdWlbKq24s2_kUIwUUEeuSTrE9Jkt2LAXu2DG3U4KAbqGJ3aqT-iU8foFAiVS2Y_v58zd9nfX9yfWWXA5gTA7Ev2KqhoXBZC6wKapKx3_zno8i8dM7jJGT3c4AHjzs9hytYrpiJXoD4dt-i4RCzvD5NCiB_72sfO</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Charafeddine, Khalil M</creator><creator>Mahfouz, Rami A</creator><creator>Zaatari, Ghazi S</creator><creator>Ibrahim, Georges Y</creator><creator>Muwakkit, Samar A</creator><creator>Najm, Nada D</creator><creator>Farra, Chantal G</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20100701</creationdate><title>Essential thrombocythemia with myelofibrosis transformed into acute myeloid leukemia with der(1;15)(q10;q10): case report and literature review</title><author>Charafeddine, Khalil M ; Mahfouz, Rami A ; Zaatari, Ghazi S ; Ibrahim, Georges Y ; Muwakkit, Samar A ; Najm, Nada D ; Farra, Chantal G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-d99c12085a2d0ba44de02d126e82e02533b9e9165040d9897e60fb7a1447ef243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, Pair 11</topic><topic>Chromosomes, Human, Pair 15</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Medical Education</topic><topic>Primary Myelofibrosis - genetics</topic><topic>Thrombocythemia, Essential - genetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Charafeddine, Khalil M</creatorcontrib><creatorcontrib>Mahfouz, Rami A</creatorcontrib><creatorcontrib>Zaatari, Ghazi S</creatorcontrib><creatorcontrib>Ibrahim, Georges Y</creatorcontrib><creatorcontrib>Muwakkit, Samar A</creatorcontrib><creatorcontrib>Najm, Nada D</creatorcontrib><creatorcontrib>Farra, Chantal G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Charafeddine, Khalil M</au><au>Mahfouz, Rami A</au><au>Zaatari, Ghazi S</au><au>Ibrahim, Georges Y</au><au>Muwakkit, Samar A</au><au>Najm, Nada D</au><au>Farra, Chantal G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Essential thrombocythemia with myelofibrosis transformed into acute myeloid leukemia with der(1;15)(q10;q10): case report and literature review</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>200</volume><issue>1</issue><spage>28</spage><epage>33</epage><pages>28-33</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><abstract>Abstract Translocations involving chromosomes 1 and 15 are uncommon in hematologic malignancies. So far, only 42 cases have been reported with t(1;15) as a reciprocal or complex chromosomal abnormalities. We herein report the first case in the literature, to our knowledge, of a 44-year-old female with essential thrombocythemia and severe myelofibrosis who developed acute myeloid leukemia (AML-M4) with der(1;15)(q10;q10) after 13 years of treatment. In addition, we reviewed the literature for all up-to-date published cases with t(1;15).</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20513531</pmid><doi>10.1016/j.cancergencyto.2010.03.010</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-4608 |
| ispartof | Cancer genetics and cytogenetics, 2010-07, Vol.200 (1), p.28-33 |
| issn | 0165-4608 1873-4456 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_754869628 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Chromosome Aberrations Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 15 Female Hematology, Oncology and Palliative Medicine Humans Leukemia, Myeloid, Acute - genetics Medical Education Primary Myelofibrosis - genetics Thrombocythemia, Essential - genetics |
| title | Essential thrombocythemia with myelofibrosis transformed into acute myeloid leukemia with der(1;15)(q10;q10): case report and literature review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T17%3A16%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Essential%20thrombocythemia%20with%20myelofibrosis%20transformed%20into%20acute%20myeloid%20leukemia%20with%20der(1;15)(q10;q10):%20case%20report%20and%20literature%20review&rft.jtitle=Cancer%20genetics%20and%20cytogenetics&rft.au=Charafeddine,%20Khalil%20M&rft.date=2010-07-01&rft.volume=200&rft.issue=1&rft.spage=28&rft.epage=33&rft.pages=28-33&rft.issn=0165-4608&rft.eissn=1873-4456&rft_id=info:doi/10.1016/j.cancergencyto.2010.03.010&rft_dat=%3Cproquest_cross%3E754869628%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733136053&rft_id=info:pmid/20513531&rft_els_id=S0165460810001433&rfr_iscdi=true |