Clinical, biological, and molecular characteristics of clonal mast cell disorders presenting with systemic mast cell activation symptoms

Background Systemic mast cell activation disorders (MCADs) are characterized by severe and systemic mast cell (MC) mediators–related symptoms frequently associated with increased serum baseline tryptase (sBt). Objective To analyze the clinical, biological, and molecular characteristics of adult pati...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2010-06, Vol.125 (6), p.1269-1278.e2
Hauptverfasser:	Álvarez-Twose, Iván, MD, González de Olano, David, MD, Sánchez-Muñoz, Laura, MD, PhD, Matito, Almudena, MD, Esteban-López, Maria I., MD, Vega, Arantza, MD, PhD, Mateo, Maria Belén, MD, Alonso Díaz de Durana, Maria D., MD, de la Hoz, Belén, MD, PhD, del Pozo Gil, Maria D., MD, PhD, Caballero, Teresa, MD, Rosado, Ana, MD, Sánchez Matas, Isabel, MD, Teodósio, Cristina, MSc, Jara-Acevedo, María, Msc, Mollejo, Manuela, MD, PhD, García-Montero, Andrés, PhD, Orfao, Alberto, MD, PhD, Escribano, Luis, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Adolescent Adult Aged Allergy and Immunology anaphylaxis Biological and medical sciences Bone marrow Bone Marrow Cells - metabolism Bone Marrow Cells - pathology CD25 Cell Degranulation clonal Clone Cells Female Fundamental and applied biological sciences. Psychology Fundamental immunology Heart Arrest Humans Hypotension Immunopathology Interleukin-2 Receptor alpha Subunit - biosynthesis KIT mutation Laboratories Male Mast cell Mast Cells - metabolism Mast Cells - pathology mastocytosis Mastocytosis, Systemic - blood Mastocytosis, Systemic - diagnosis Mastocytosis, Systemic - pathology Mastocytosis, Systemic - physiopathology Medical sciences Middle Aged Multivariate analysis Mutation Mutation - genetics Patients Proto-Oncogene Proteins c-kit - genetics Receptors, Androgen - metabolism Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis score Syncope systemic mast cell activation disorders Tomography Tryptases - blood Variables
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