Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain

Studies in vitro suggest that the expression of the serotonin transporter (5-HTT) is regulated by polymorphic variation in the promoter region of the 5-HTT gene (5-HTTLPR); however, results from human brain imaging studies examining the relation between 5-HTT genotype and 5-HTT radioligand binding i...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2010-08, Vol.52 (1), p.50-54
Hauptverfasser:	Murthy, N.V., Selvaraj, S., Cowen, P.J., Bhagwagar, Z., Riedel, W.J., Peers, P., Kennedy, J.L., Sahakian, B.J., Laruelle, M.A., Rabiner, E.A., Grasby, P.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HTTLPR [11C] DASB Adult Alleles Benzylamines Brain - diagnostic imaging Brain - metabolism Brain Mapping Brain research Carbon Radioisotopes Cross-Sectional Studies Europe European Continental Ancestry Group - genetics Gene Genotype & phenotype Humans INDEL Mutation Ligands Magnetic resonance imaging Male Polymorphism, Genetic Polymorphism, Single Nucleotide Positron emission tomography Promoter Regions, Genetic Sequence Analysis, DNA Serotonin Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - metabolism SERT Studies
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