Intercellular movement of the putative transcription factor SHR in root patterning
Positional information is pivotal for establishing developmental patterning in plants, but little is known about the underlying signalling mechanisms. The Arabidopsis root radial pattern is generated through stereotyped division of initial cells and the subsequent acquisition of cell fate. short-roo...
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| Veröffentlicht in: | Nature (London) 2001-09, Vol.413 (6853), p.307-311 |
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| creator | Benfey, Philip N Nakajima, Keiji Sena, Giovanni Nawy, Tal |
| description | Positional information is pivotal for establishing developmental patterning in plants, but little is known about the underlying signalling mechanisms. The Arabidopsis root radial pattern is generated through stereotyped division of initial cells and the subsequent acquisition of cell fate. short-root (shr) mutants do not undergo the longitudinal cell division of the cortex/endodermis initial daughter cell, resulting in a single cell layer with only cortex attributes. Thus, SHR is necessary for both cell division and endodermis specification. SHR messenger RNA is found exclusively in the stele cells internal to the endodermis and cortex, indicating that it has a non-cell-autonomous mode of action. Here we show that the SHR protein, a putative transcription factor, moves from the stele to a single layer of adjacent cells, where it enters the nucleus. Ectopic expression of SHR driven by the promoter of the downstream gene SCARECROW (SCR) results in autocatalytic reinforcement of SHR signalling, producing altered cell fates and multiplication of cell layers. These results support a model in which SHR protein acts both as a signal from the stele and as an activator of endodermal cell fate and SCR-mediated cell division. |
| doi_str_mv | 10.1038/35095061 |
| format | Article |
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The Arabidopsis root radial pattern is generated through stereotyped division of initial cells and the subsequent acquisition of cell fate. short-root (shr) mutants do not undergo the longitudinal cell division of the cortex/endodermis initial daughter cell, resulting in a single cell layer with only cortex attributes. Thus, SHR is necessary for both cell division and endodermis specification. SHR messenger RNA is found exclusively in the stele cells internal to the endodermis and cortex, indicating that it has a non-cell-autonomous mode of action. Here we show that the SHR protein, a putative transcription factor, moves from the stele to a single layer of adjacent cells, where it enters the nucleus. Ectopic expression of SHR driven by the promoter of the downstream gene SCARECROW (SCR) results in autocatalytic reinforcement of SHR signalling, producing altered cell fates and multiplication of cell layers. These results support a model in which SHR protein acts both as a signal from the stele and as an activator of endodermal cell fate and SCR-mediated cell division.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/35095061</identifier><identifier>PMID: 11565032</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Arabidopsis ; Arabidopsis - cytology ; Arabidopsis Proteins ; Biological and medical sciences ; Cell Differentiation - physiology ; Cells ; Flowers & plants ; Fundamental and applied biological sciences. Psychology ; Glucuronidase - genetics ; Humanities and Social Sciences ; letter ; Mode of action ; multidisciplinary ; Plant growth. Development of the storage organs ; Plant physiology and development ; Plant Roots - cytology ; Plants, Genetically Modified ; Protein Transport ; Proteins ; RNA, Messenger - metabolism ; RNA, Plant - metabolism ; SCARECROW gene ; Science ; Science (multidisciplinary) ; SHR protein ; Signal Transduction ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Vegetative apparatus, growth and morphogenesis. Senescence</subject><ispartof>Nature (London), 2001-09, Vol.413 (6853), p.307-311</ispartof><rights>Macmillan Magazines Ltd. 2001</rights><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 Nature Publishing Group</rights><rights>Copyright Macmillan Journals Ltd. Sep 20, 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-783c84e21d7798b36854dbe47358950a37075317024ab3b9f12cab91b0f6a0553</citedby><cites>FETCH-LOGICAL-c758t-783c84e21d7798b36854dbe47358950a37075317024ab3b9f12cab91b0f6a0553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/35095061$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/35095061$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1098496$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11565032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benfey, Philip N</creatorcontrib><creatorcontrib>Nakajima, Keiji</creatorcontrib><creatorcontrib>Sena, Giovanni</creatorcontrib><creatorcontrib>Nawy, Tal</creatorcontrib><title>Intercellular movement of the putative transcription factor SHR in root patterning</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Positional information is pivotal for establishing developmental patterning in plants, but little is known about the underlying signalling mechanisms. The Arabidopsis root radial pattern is generated through stereotyped division of initial cells and the subsequent acquisition of cell fate. short-root (shr) mutants do not undergo the longitudinal cell division of the cortex/endodermis initial daughter cell, resulting in a single cell layer with only cortex attributes. Thus, SHR is necessary for both cell division and endodermis specification. SHR messenger RNA is found exclusively in the stele cells internal to the endodermis and cortex, indicating that it has a non-cell-autonomous mode of action. Here we show that the SHR protein, a putative transcription factor, moves from the stele to a single layer of adjacent cells, where it enters the nucleus. Ectopic expression of SHR driven by the promoter of the downstream gene SCARECROW (SCR) results in autocatalytic reinforcement of SHR signalling, producing altered cell fates and multiplication of cell layers. These results support a model in which SHR protein acts both as a signal from the stele and as an activator of endodermal cell fate and SCR-mediated cell division.</description><subject>Arabidopsis</subject><subject>Arabidopsis - cytology</subject><subject>Arabidopsis Proteins</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - physiology</subject><subject>Cells</subject><subject>Flowers & plants</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucuronidase - genetics</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Mode of action</subject><subject>multidisciplinary</subject><subject>Plant growth. Development of the storage organs</subject><subject>Plant physiology and development</subject><subject>Plant Roots - cytology</subject><subject>Plants, Genetically Modified</subject><subject>Protein Transport</subject><subject>Proteins</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA, Plant - metabolism</subject><subject>SCARECROW gene</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>SHR protein</subject><subject>Signal Transduction</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Vegetative apparatus, growth and morphogenesis. 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| ispartof | Nature (London), 2001-09, Vol.413 (6853), p.307-311 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Arabidopsis Arabidopsis - cytology Arabidopsis Proteins Biological and medical sciences Cell Differentiation - physiology Cells Flowers & plants Fundamental and applied biological sciences. Psychology Glucuronidase - genetics Humanities and Social Sciences letter Mode of action multidisciplinary Plant growth. Development of the storage organs Plant physiology and development Plant Roots - cytology Plants, Genetically Modified Protein Transport Proteins RNA, Messenger - metabolism RNA, Plant - metabolism SCARECROW gene Science Science (multidisciplinary) SHR protein Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism Vegetative apparatus, growth and morphogenesis. Senescence |
| title | Intercellular movement of the putative transcription factor SHR in root patterning |
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