The effect of vitamin D on urinary citrate in relation to calcium, phosphorus and urinary pH
Vitamin D increased the amount of urinary citrate excreted by young rats kept on rations varying widely in mineral content. These rations ranged in composition from those providing an adequate mineral intake to those made grossly deficient in Ca, P, and other minerals. The biggest percentage increas...
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| Veröffentlicht in: | Archives of biochemistry and biophysics 1954-05, Vol.50 (1), p.18-24 |
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| container_title | Archives of biochemistry and biophysics |
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| creator | Bellin, Stuart A. Herting, David C. Cramer, John W. Pileggi, Vincent J. Steenbock, Harry |
| description | Vitamin D increased the amount of urinary citrate excreted by young rats kept on rations varying widely in mineral content. These rations ranged in composition from those providing an adequate mineral intake to those made grossly deficient in Ca, P, and other minerals. The biggest percentage increase in citrate was obtained with P-containing rations, but supplements of P, given in the form of neutral solutions of K phosphates to a low-P ration, reduced citrate elimination. An increase in urinary pH induced by vitamin D with rats on low-P rachitogenic rations was not obtained with rations adequate in P, yet an increase in citrate elimination resulted in all instances. Inasmuch as a supplement of vitamin D increased urinary citrate far more than did an additional large intake of NaHCO
3, it appears that the effect of vitamin D is due to an increase in citrate synthesis rather than to a decrease in its destruction. |
| doi_str_mv | 10.1016/0003-9861(54)90004-1 |
| format | Article |
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3, it appears that the effect of vitamin D is due to an increase in citrate synthesis rather than to a decrease in its destruction.</description><identifier>ISSN: 0003-9861</identifier><identifier>EISSN: 1096-0384</identifier><identifier>DOI: 10.1016/0003-9861(54)90004-1</identifier><identifier>PMID: 13159296</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biochemical Phenomena ; Calcium ; Calcium, Dietary ; Citrates - metabolism ; Citric Acid ; Humans ; Hydrogen-Ion Concentration ; Old Medline ; Phosphorus ; Urine ; Vitamin D - pharmacology ; Vitamins</subject><ispartof>Archives of biochemistry and biophysics, 1954-05, Vol.50 (1), p.18-24</ispartof><rights>1954</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-105e33cd61f6125a207675981b590c764138ebc7fa6d535d3d98dd7433ccff663</citedby><cites>FETCH-LOGICAL-c360t-105e33cd61f6125a207675981b590c764138ebc7fa6d535d3d98dd7433ccff663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0003-9861(54)90004-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13159296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bellin, Stuart A.</creatorcontrib><creatorcontrib>Herting, David C.</creatorcontrib><creatorcontrib>Cramer, John W.</creatorcontrib><creatorcontrib>Pileggi, Vincent J.</creatorcontrib><creatorcontrib>Steenbock, Harry</creatorcontrib><title>The effect of vitamin D on urinary citrate in relation to calcium, phosphorus and urinary pH</title><title>Archives of biochemistry and biophysics</title><addtitle>Arch Biochem Biophys</addtitle><description>Vitamin D increased the amount of urinary citrate excreted by young rats kept on rations varying widely in mineral content. These rations ranged in composition from those providing an adequate mineral intake to those made grossly deficient in Ca, P, and other minerals. The biggest percentage increase in citrate was obtained with P-containing rations, but supplements of P, given in the form of neutral solutions of K phosphates to a low-P ration, reduced citrate elimination. An increase in urinary pH induced by vitamin D with rats on low-P rachitogenic rations was not obtained with rations adequate in P, yet an increase in citrate elimination resulted in all instances. Inasmuch as a supplement of vitamin D increased urinary citrate far more than did an additional large intake of NaHCO
3, it appears that the effect of vitamin D is due to an increase in citrate synthesis rather than to a decrease in its destruction.</description><subject>Biochemical Phenomena</subject><subject>Calcium</subject><subject>Calcium, Dietary</subject><subject>Citrates - metabolism</subject><subject>Citric Acid</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Old Medline</subject><subject>Phosphorus</subject><subject>Urine</subject><subject>Vitamin D - pharmacology</subject><subject>Vitamins</subject><issn>0003-9861</issn><issn>1096-0384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1954</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlKBDEQhoMoOi5vIJKTKNiamizdfRHEHQQvehNCJqlgpJcx6R7w7c04g948FKGS768kHyGHwM6BgbpgjPGirhScSHFa504UsEEmwGpVMF6JTTL5RXbIbkofjAEINd0mO8BB1tNaTcjbyztS9B7tQHtPF2EwbejoDe07OsbQmfhFbRiiGZDm_YiNGUI-G3pqTWPD2J7R-XufcsUxUdO539j8YZ9sedMkPFive-T17vbl-qF4er5_vL56KixXbCiASeTcOgVewVSaKStVKesKZrJmtlQCeIUzW3qjnOTScVdXzpUiZ6z3SvE9cryaO4_954hp0G1IFpvGdNiPSZdSlLKSVQbFCrSxTymi1_MY2vxYDUwvreqlMr1UpqXQP1Y15NjRev44a9H9hdYaM3C5AjD_chEw6mQDdhZdiNmsdn34_4Zvw76Fpg</recordid><startdate>195405</startdate><enddate>195405</enddate><creator>Bellin, Stuart A.</creator><creator>Herting, David C.</creator><creator>Cramer, John W.</creator><creator>Pileggi, Vincent J.</creator><creator>Steenbock, Harry</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195405</creationdate><title>The effect of vitamin D on urinary citrate in relation to calcium, phosphorus and urinary pH</title><author>Bellin, Stuart A. ; Herting, David C. ; Cramer, John W. ; Pileggi, Vincent J. ; Steenbock, Harry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-105e33cd61f6125a207675981b590c764138ebc7fa6d535d3d98dd7433ccff663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1954</creationdate><topic>Biochemical Phenomena</topic><topic>Calcium</topic><topic>Calcium, Dietary</topic><topic>Citrates - metabolism</topic><topic>Citric Acid</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Old Medline</topic><topic>Phosphorus</topic><topic>Urine</topic><topic>Vitamin D - pharmacology</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bellin, Stuart A.</creatorcontrib><creatorcontrib>Herting, David C.</creatorcontrib><creatorcontrib>Cramer, John W.</creatorcontrib><creatorcontrib>Pileggi, Vincent J.</creatorcontrib><creatorcontrib>Steenbock, Harry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bellin, Stuart A.</au><au>Herting, David C.</au><au>Cramer, John W.</au><au>Pileggi, Vincent J.</au><au>Steenbock, Harry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of vitamin D on urinary citrate in relation to calcium, phosphorus and urinary pH</atitle><jtitle>Archives of biochemistry and biophysics</jtitle><addtitle>Arch Biochem Biophys</addtitle><date>1954-05</date><risdate>1954</risdate><volume>50</volume><issue>1</issue><spage>18</spage><epage>24</epage><pages>18-24</pages><issn>0003-9861</issn><eissn>1096-0384</eissn><abstract>Vitamin D increased the amount of urinary citrate excreted by young rats kept on rations varying widely in mineral content. These rations ranged in composition from those providing an adequate mineral intake to those made grossly deficient in Ca, P, and other minerals. The biggest percentage increase in citrate was obtained with P-containing rations, but supplements of P, given in the form of neutral solutions of K phosphates to a low-P ration, reduced citrate elimination. An increase in urinary pH induced by vitamin D with rats on low-P rachitogenic rations was not obtained with rations adequate in P, yet an increase in citrate elimination resulted in all instances. Inasmuch as a supplement of vitamin D increased urinary citrate far more than did an additional large intake of NaHCO
3, it appears that the effect of vitamin D is due to an increase in citrate synthesis rather than to a decrease in its destruction.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>13159296</pmid><doi>10.1016/0003-9861(54)90004-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-9861 |
| ispartof | Archives of biochemistry and biophysics, 1954-05, Vol.50 (1), p.18-24 |
| issn | 0003-9861 1096-0384 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biochemical Phenomena Calcium Calcium, Dietary Citrates - metabolism Citric Acid Humans Hydrogen-Ion Concentration Old Medline Phosphorus Urine Vitamin D - pharmacology Vitamins |
| title | The effect of vitamin D on urinary citrate in relation to calcium, phosphorus and urinary pH |
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