Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges

Benzamide and m-aminobenzamide, which are the most potent inhibitors of poly(adenosine diphosphate ribose) polymerase known, induced many sister chromatid exchanges (SCEs) in Chinese hamster ovary cells CHO-K1. Nicotinamide, o-aminobenzamide, p-aminobenzamide and 3-acetylpyridine, which are moderate...

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Veröffentlicht in:	Biochemical and biophysical research communications 1980-12, Vol.97 (4), p.1311-1316
Hauptverfasser:	Oikawa, Atsushi, Tohda, Hiroko, Kanai, Mieko, Miwa, Masanao, Sugimura, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzamides - pharmacology Cell Line Cricetinae Cricetulus Crossing Over, Genetic - drug effects Female Kinetics NAD+ Nucleosidase - antagonists & inhibitors Ovary Poly(ADP-ribose) Polymerase Inhibitors Sister Chromatid Exchange - drug effects Structure-Activity Relationship
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