Hyperplasia of islets of langerhans and low serum insulin in cot deaths
Of the fifty-seven cases of cot death studied two-thirds were younger than 3 months, which is also the peak age of infantile hypoglycaemia. Findings from routine necropsy and histology were scarce; in eleven cases they could be regarded as potentially fatal. About half of the infants had had a mild...
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Veröffentlicht in: | Forensic science international 1980-11, Vol.16 (3), p.213-226 |
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description | Of the fifty-seven cases of cot death studied two-thirds were younger than 3 months, which is also the peak age of infantile hypoglycaemia. Findings from routine necropsy and histology were scarce; in eleven cases they could be regarded as potentially fatal. About half of the infants had had a mild virus-type infection approximately one week before death. Special attention was paid to endocrine pancreas. Insulitis or lymphocytes in the septa were discovered in twelve cases. Hyperplasia of the islets of Langerhans was a common observation; the hyperplasia being either nesidioblastosis-like with clusters of islets around ducti, or diffuse. The average proportion of islet tissue in the whole pancreas parenchyma was around 5% in infants aged 1–6 months, the percentage being significantly greater than in age-matched controls (4.3%). The pancreatic insulin content was also higher in the cot death cases. Serum insulin values were low (mean 4.8 ± 1.2 μU/ml) in cot deaths; in the controls they were twice as high (mean 11.6 ± 1.6 μU/ml) (
p < 0.005). The cause of death in this group of cot deaths could thus be (congenital?) hyperplasia of the islets, possibly combined with a lesion in the B-cells caused by a virus. The mechanism of death would be hypoglycaemia. |
doi_str_mv | 10.1016/0379-0738(80)90205-4 |
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p < 0.005). The cause of death in this group of cot deaths could thus be (congenital?) hyperplasia of the islets, possibly combined with a lesion in the B-cells caused by a virus. The mechanism of death would be hypoglycaemia.</description><identifier>ISSN: 0379-0738</identifier><identifier>EISSN: 1872-6283</identifier><identifier>DOI: 10.1016/0379-0738(80)90205-4</identifier><identifier>PMID: 7009350</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Female ; Humans ; Hyperplasia - pathology ; Infant ; Insulin - blood ; Islets of Langerhans - pathology ; Male ; Pancreas - pathology ; Sudden Infant Death - blood ; Sudden Infant Death - pathology</subject><ispartof>Forensic science international, 1980-11, Vol.16 (3), p.213-226</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-960920c30fd32f12f7c6ffc194e106f52862438d72a8dad6c331d54a35a2801f3</citedby><cites>FETCH-LOGICAL-c357t-960920c30fd32f12f7c6ffc194e106f52862438d72a8dad6c331d54a35a2801f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0379-0738(80)90205-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7009350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirvonen, J.</creatorcontrib><creatorcontrib>Jantti, M.</creatorcontrib><creatorcontrib>Syrjala, H.</creatorcontrib><creatorcontrib>Lautala, P.</creatorcontrib><creatorcontrib>Akerblom, H.K.</creatorcontrib><title>Hyperplasia of islets of langerhans and low serum insulin in cot deaths</title><title>Forensic science international</title><addtitle>Forensic Sci Int</addtitle><description>Of the fifty-seven cases of cot death studied two-thirds were younger than 3 months, which is also the peak age of infantile hypoglycaemia. Findings from routine necropsy and histology were scarce; in eleven cases they could be regarded as potentially fatal. About half of the infants had had a mild virus-type infection approximately one week before death. Special attention was paid to endocrine pancreas. Insulitis or lymphocytes in the septa were discovered in twelve cases. Hyperplasia of the islets of Langerhans was a common observation; the hyperplasia being either nesidioblastosis-like with clusters of islets around ducti, or diffuse. The average proportion of islet tissue in the whole pancreas parenchyma was around 5% in infants aged 1–6 months, the percentage being significantly greater than in age-matched controls (4.3%). The pancreatic insulin content was also higher in the cot death cases. Serum insulin values were low (mean 4.8 ± 1.2 μU/ml) in cot deaths; in the controls they were twice as high (mean 11.6 ± 1.6 μU/ml) (
p < 0.005). The cause of death in this group of cot deaths could thus be (congenital?) hyperplasia of the islets, possibly combined with a lesion in the B-cells caused by a virus. The mechanism of death would be hypoglycaemia.</description><subject>Female</subject><subject>Humans</subject><subject>Hyperplasia - pathology</subject><subject>Infant</subject><subject>Insulin - blood</subject><subject>Islets of Langerhans - pathology</subject><subject>Male</subject><subject>Pancreas - pathology</subject><subject>Sudden Infant Death - blood</subject><subject>Sudden Infant Death - pathology</subject><issn>0379-0738</issn><issn>1872-6283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KAzEUhYMotVbfQGFWoovRm2SSyWwEKdoKBTe6DjG5sZHpTE1mlL69U1tcujoXzrl_HyHnFG4oUHkLvKxyKLm6UnBdAQORFwdkTFXJcskUPyTjv8gxOUnpAwCEYHJERiVAxQWMyWy-WWNc1yYFk7U-C6nGLm2r2jTvGJemSZlpXFa331nC2K-y0KS-Ds2gmW27zKHplumUHHlTJzzb64S8Pj68TOf54nn2NL1f5JaLsssrCRUDy8E7zjxlvrTSe0urAilIL5iSrODKlcwoZ5y0nFMnCsOFYQqo5xNyuZu7ju1nj6nTq5As1sO12PZJl6KQTKhqCBa7oI1tShG9XsewMnGjKegtP72Fo7dwtAL9y08XQ9vFfn7_tkL317QHNvh3Ox-HJ78CRp1swMaiCxFtp10b_l_wAylKfgo</recordid><startdate>198011</startdate><enddate>198011</enddate><creator>Hirvonen, J.</creator><creator>Jantti, M.</creator><creator>Syrjala, H.</creator><creator>Lautala, P.</creator><creator>Akerblom, H.K.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198011</creationdate><title>Hyperplasia of islets of langerhans and low serum insulin in cot deaths</title><author>Hirvonen, J. ; Jantti, M. ; Syrjala, H. ; Lautala, P. ; Akerblom, H.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-960920c30fd32f12f7c6ffc194e106f52862438d72a8dad6c331d54a35a2801f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Female</topic><topic>Humans</topic><topic>Hyperplasia - pathology</topic><topic>Infant</topic><topic>Insulin - blood</topic><topic>Islets of Langerhans - pathology</topic><topic>Male</topic><topic>Pancreas - pathology</topic><topic>Sudden Infant Death - blood</topic><topic>Sudden Infant Death - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirvonen, J.</creatorcontrib><creatorcontrib>Jantti, M.</creatorcontrib><creatorcontrib>Syrjala, H.</creatorcontrib><creatorcontrib>Lautala, P.</creatorcontrib><creatorcontrib>Akerblom, H.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Forensic science international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirvonen, J.</au><au>Jantti, M.</au><au>Syrjala, H.</au><au>Lautala, P.</au><au>Akerblom, H.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperplasia of islets of langerhans and low serum insulin in cot deaths</atitle><jtitle>Forensic science international</jtitle><addtitle>Forensic Sci Int</addtitle><date>1980-11</date><risdate>1980</risdate><volume>16</volume><issue>3</issue><spage>213</spage><epage>226</epage><pages>213-226</pages><issn>0379-0738</issn><eissn>1872-6283</eissn><abstract>Of the fifty-seven cases of cot death studied two-thirds were younger than 3 months, which is also the peak age of infantile hypoglycaemia. Findings from routine necropsy and histology were scarce; in eleven cases they could be regarded as potentially fatal. About half of the infants had had a mild virus-type infection approximately one week before death. Special attention was paid to endocrine pancreas. Insulitis or lymphocytes in the septa were discovered in twelve cases. Hyperplasia of the islets of Langerhans was a common observation; the hyperplasia being either nesidioblastosis-like with clusters of islets around ducti, or diffuse. The average proportion of islet tissue in the whole pancreas parenchyma was around 5% in infants aged 1–6 months, the percentage being significantly greater than in age-matched controls (4.3%). The pancreatic insulin content was also higher in the cot death cases. Serum insulin values were low (mean 4.8 ± 1.2 μU/ml) in cot deaths; in the controls they were twice as high (mean 11.6 ± 1.6 μU/ml) (
p < 0.005). The cause of death in this group of cot deaths could thus be (congenital?) hyperplasia of the islets, possibly combined with a lesion in the B-cells caused by a virus. The mechanism of death would be hypoglycaemia.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>7009350</pmid><doi>10.1016/0379-0738(80)90205-4</doi><tpages>14</tpages></addata></record> |
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subjects | Female Humans Hyperplasia - pathology Infant Insulin - blood Islets of Langerhans - pathology Male Pancreas - pathology Sudden Infant Death - blood Sudden Infant Death - pathology |
title | Hyperplasia of islets of langerhans and low serum insulin in cot deaths |
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