Antagonism of intrastriatal and intravenous kainic acid by 1-nuciferine: Comparison with various anticonvulsants and gabamimetics

1-Nuciferine has been proposed as an antagonist of kainic acid (KA) and/or glutamate on the basis of iontophoretic experimental results. Its effectiveness against KA-induced destruction of rat striatal cholinergic neurons was therefore evaluated and compared with that of diazepam, phenobarbital, bac...

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Veröffentlicht in:	Life sciences (1973) 1980-01, Vol.27 (21), p.1991-1998
Hauptverfasser:	Liebman, J.M., Pastor, G., Bernard, P.S., Saelens, J.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aporphines - pharmacology Baclofen - pharmacology Behavior, Animal - drug effects Choline O-Acetyltransferase - metabolism Corpus Striatum - metabolism Diazepam - pharmacology Excitatory Amino Acid Antagonists Haloperidol - pharmacology Injections Kainic Acid - antagonists & inhibitors Male Phenobarbital - pharmacology Pyrrolidines - antagonists & inhibitors Rats Seizures - drug therapy
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