Effect of S-COMT deficiency on behavior and extracellular brain dopamine concentrations in mice

Introduction Catechol- O -methyltransferase (COMT) has soluble (S-COMT) and membrane bound (MB-COMT) isoforms. Our aims were to assess the behavioral phenotype of S-COMT mutant mice and to clarify the role of MB-COMT in dopamine metabolism in different brain areas. Methods Behavioral phenotype of th...

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Veröffentlicht in:	Psychopharmacologia 2010-09, Vol.211 (4), p.389-401
Hauptverfasser:	Tammimäki, Anne, Käenmäki, Mikko, Kambur, Oleg, Kulesskaya, Natalia, Keisala, Tiina, Karvonen, Eeva, García-Horsman, J. Arturo, Rauvala, Heikki, Männistö, Pekka T.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Animal behavior Animals Behavior, Animal Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain - metabolism Carbidopa - administration & dosage Catechol O-Methyltransferase - genetics Dopamine Dopamine - metabolism Drug Combinations Enzymes Extracellular Space - metabolism Female Genotype & phenotype Levodopa - administration & dosage Male Medical sciences Methylation Mice Mice, Inbred C57BL Mice, Knockout Microdialysis Miscellaneous Mutation Neurosciences Original Investigation Pharmacology. Drug treatments Pharmacology/Toxicology Phenotype Psychiatry Psychopharmacology Rodents Sensory Gating - genetics Sex Factors Social Dominance
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