Serial MRI and Neurodevelopmental Outcome in 9- to 10-Year-Old Children with Neonatal Encephalopathy
Objective To assess the relation between patterns of brain injury on neonatal and childhood magnetic resonance imaging (MRI) and long-term neurodevelopmental outcome. Study design Neonatal (n = 34) and childhood MRIs (n = 77) were analyzed for 80 children with neonatal encephalopathy and for 51 cont...
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creator | van Kooij, Britt J.M., MD van Handel, Mariëlle, MSc Nievelstein, Rutger A.J., MD, PhD Groenendaal, Floris, MD, PhD Jongmans, Marian J., PhD de Vries, Linda S., MD, PhD |
description | Objective To assess the relation between patterns of brain injury on neonatal and childhood magnetic resonance imaging (MRI) and long-term neurodevelopmental outcome. Study design Neonatal (n = 34) and childhood MRIs (n = 77) were analyzed for 80 children with neonatal encephalopathy and for 51 control subjects during childhood. MRIs were graded as normal, mildly abnormal (white matter lesions), or moderately/severely abnormal (watershed injury, lesions in basal ganglia/thalamus or focal infarction). Severity of brain injury was related to different aspects of neurologic outcome: Total impairment score of the Movement Assessment Battery for Children, intelligence quotient score, cerebral palsy, postneonatal epilepsy, and need for special education. Seven children with neonatal encephalopathy required extracorporeal membrane oxygenation treatment. Results Neonatal and childhood MRI were comparable in 25/33 children (75.8%, P < .001). Children with moderate/severe lesions on neonatal or childhood MRI more often had a total impairment score ≤ 15th percentile, an intelligence quotient ≤ 85, and cerebral palsy, and attended special education. Conclusion Different patterns of injury seen on neonatal MRI after neonatal encephalopathy can still be recognized on childhood MRI. Children with moderate to severe brain lesions on neonatal or childhood MRI significantly more often have impaired motor and cognitive outcomes. |
doi_str_mv | 10.1016/j.jpeds.2010.02.016 |
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Study design Neonatal (n = 34) and childhood MRIs (n = 77) were analyzed for 80 children with neonatal encephalopathy and for 51 control subjects during childhood. MRIs were graded as normal, mildly abnormal (white matter lesions), or moderately/severely abnormal (watershed injury, lesions in basal ganglia/thalamus or focal infarction). Severity of brain injury was related to different aspects of neurologic outcome: Total impairment score of the Movement Assessment Battery for Children, intelligence quotient score, cerebral palsy, postneonatal epilepsy, and need for special education. Seven children with neonatal encephalopathy required extracorporeal membrane oxygenation treatment. Results Neonatal and childhood MRI were comparable in 25/33 children (75.8%, P < .001). Children with moderate/severe lesions on neonatal or childhood MRI more often had a total impairment score ≤ 15th percentile, an intelligence quotient ≤ 85, and cerebral palsy, and attended special education. Conclusion Different patterns of injury seen on neonatal MRI after neonatal encephalopathy can still be recognized on childhood MRI. Children with moderate to severe brain lesions on neonatal or childhood MRI significantly more often have impaired motor and cognitive outcomes.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2010.02.016</identifier><identifier>PMID: 20381069</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>Maryland Heights, MO: Mosby, Inc</publisher><subject>Asphyxia Neonatorum - physiopathology ; Biological and medical sciences ; Brain Diseases - diagnosis ; Brain Diseases - physiopathology ; Brain Injuries - diagnosis ; Brain Injuries - physiopathology ; Case-Control Studies ; Cerebral Palsy - diagnosis ; Child ; Female ; General aspects ; Humans ; Infant, Newborn ; Intelligence Tests ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Pediatrics ; Risk ; Treatment Outcome</subject><ispartof>The Journal of pediatrics, 2010-08, Vol.157 (2), p.221-227.e2</ispartof><rights>Mosby, Inc.</rights><rights>2010 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-53416fea2bf8e99e3bac913ae3af8bbe4da94be6c1845cbcc25a50168689f7803</citedby><cites>FETCH-LOGICAL-c475t-53416fea2bf8e99e3bac913ae3af8bbe4da94be6c1845cbcc25a50168689f7803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2010.02.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23061135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20381069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Kooij, Britt J.M., MD</creatorcontrib><creatorcontrib>van Handel, Mariëlle, MSc</creatorcontrib><creatorcontrib>Nievelstein, Rutger A.J., MD, PhD</creatorcontrib><creatorcontrib>Groenendaal, Floris, MD, PhD</creatorcontrib><creatorcontrib>Jongmans, Marian J., PhD</creatorcontrib><creatorcontrib>de Vries, Linda S., MD, PhD</creatorcontrib><title>Serial MRI and Neurodevelopmental Outcome in 9- to 10-Year-Old Children with Neonatal Encephalopathy</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective To assess the relation between patterns of brain injury on neonatal and childhood magnetic resonance imaging (MRI) and long-term neurodevelopmental outcome. Study design Neonatal (n = 34) and childhood MRIs (n = 77) were analyzed for 80 children with neonatal encephalopathy and for 51 control subjects during childhood. MRIs were graded as normal, mildly abnormal (white matter lesions), or moderately/severely abnormal (watershed injury, lesions in basal ganglia/thalamus or focal infarction). Severity of brain injury was related to different aspects of neurologic outcome: Total impairment score of the Movement Assessment Battery for Children, intelligence quotient score, cerebral palsy, postneonatal epilepsy, and need for special education. Seven children with neonatal encephalopathy required extracorporeal membrane oxygenation treatment. Results Neonatal and childhood MRI were comparable in 25/33 children (75.8%, P < .001). Children with moderate/severe lesions on neonatal or childhood MRI more often had a total impairment score ≤ 15th percentile, an intelligence quotient ≤ 85, and cerebral palsy, and attended special education. Conclusion Different patterns of injury seen on neonatal MRI after neonatal encephalopathy can still be recognized on childhood MRI. Children with moderate to severe brain lesions on neonatal or childhood MRI significantly more often have impaired motor and cognitive outcomes.</description><subject>Asphyxia Neonatorum - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Brain Diseases - diagnosis</subject><subject>Brain Diseases - physiopathology</subject><subject>Brain Injuries - diagnosis</subject><subject>Brain Injuries - physiopathology</subject><subject>Case-Control Studies</subject><subject>Cerebral Palsy - diagnosis</subject><subject>Child</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Intelligence Tests</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pediatrics</subject><subject>Risk</subject><subject>Treatment Outcome</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklGL1DAQx4Mo3nr6CQTpi_jUddI0bfOgIMt5d3C64CnoU0iTKZvaTWrSnuy3N3VXBV8uL4HJ7z8zmf8Q8pzCmgKtXvfrfkQT1wWkCBTrFHtAVhREnVcNYw_JCqAoclbW1Rl5EmMPAKIEeEzOCmANhUqsiLnFYNWQffh0nSlnso84B2_wDgc_7tFN6Wk7T9rvMbMuE3k2-YxC_g1VyLeDyTY7O5iALvtpp11Se6cWzYXTOO5USqKm3eEpedSpIeKz031Ovry_-Ly5ym-2l9ebdze5Lms-5ZyVtOpQFW3XoBDIWqUFZQqZ6pq2xdIoUbZYadqUXLdaF1zx9OumakRXN8DOyatj3jH4HzPGSe5t1DgMyqGfo6x5yat02P0kY0JwXvBEsiOpg48xYCfHYPcqHCQFufgge_nbB7n4IKGQKZZUL07553aP5q_mz-AT8PIEqKjV0AXltI3_OAYVpWwp_-bIYZrbncUgo7aYpmtsQD1J4-09jbz9T68H62wq-R0PGHs_B5cskVTGJJC3y8osG0PTstASvrJfFgu7Jg</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>van Kooij, Britt J.M., MD</creator><creator>van Handel, Mariëlle, MSc</creator><creator>Nievelstein, Rutger A.J., MD, PhD</creator><creator>Groenendaal, Floris, MD, PhD</creator><creator>Jongmans, Marian J., PhD</creator><creator>de Vries, Linda S., MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20100801</creationdate><title>Serial MRI and Neurodevelopmental Outcome in 9- to 10-Year-Old Children with Neonatal Encephalopathy</title><author>van Kooij, Britt J.M., MD ; van Handel, Mariëlle, MSc ; Nievelstein, Rutger A.J., MD, PhD ; Groenendaal, Floris, MD, PhD ; Jongmans, Marian J., PhD ; de Vries, Linda S., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-53416fea2bf8e99e3bac913ae3af8bbe4da94be6c1845cbcc25a50168689f7803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Asphyxia Neonatorum - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Brain Diseases - diagnosis</topic><topic>Brain Diseases - physiopathology</topic><topic>Brain Injuries - diagnosis</topic><topic>Brain Injuries - physiopathology</topic><topic>Case-Control Studies</topic><topic>Cerebral Palsy - diagnosis</topic><topic>Child</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Intelligence Tests</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pediatrics</topic><topic>Risk</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Kooij, Britt J.M., MD</creatorcontrib><creatorcontrib>van Handel, Mariëlle, MSc</creatorcontrib><creatorcontrib>Nievelstein, Rutger A.J., MD, PhD</creatorcontrib><creatorcontrib>Groenendaal, Floris, MD, PhD</creatorcontrib><creatorcontrib>Jongmans, Marian J., PhD</creatorcontrib><creatorcontrib>de Vries, Linda S., MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Kooij, Britt J.M., MD</au><au>van Handel, Mariëlle, MSc</au><au>Nievelstein, Rutger A.J., MD, PhD</au><au>Groenendaal, Floris, MD, PhD</au><au>Jongmans, Marian J., PhD</au><au>de Vries, Linda S., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serial MRI and Neurodevelopmental Outcome in 9- to 10-Year-Old Children with Neonatal Encephalopathy</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>157</volume><issue>2</issue><spage>221</spage><epage>227.e2</epage><pages>221-227.e2</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Objective To assess the relation between patterns of brain injury on neonatal and childhood magnetic resonance imaging (MRI) and long-term neurodevelopmental outcome. Study design Neonatal (n = 34) and childhood MRIs (n = 77) were analyzed for 80 children with neonatal encephalopathy and for 51 control subjects during childhood. MRIs were graded as normal, mildly abnormal (white matter lesions), or moderately/severely abnormal (watershed injury, lesions in basal ganglia/thalamus or focal infarction). Severity of brain injury was related to different aspects of neurologic outcome: Total impairment score of the Movement Assessment Battery for Children, intelligence quotient score, cerebral palsy, postneonatal epilepsy, and need for special education. Seven children with neonatal encephalopathy required extracorporeal membrane oxygenation treatment. Results Neonatal and childhood MRI were comparable in 25/33 children (75.8%, P < .001). Children with moderate/severe lesions on neonatal or childhood MRI more often had a total impairment score ≤ 15th percentile, an intelligence quotient ≤ 85, and cerebral palsy, and attended special education. Conclusion Different patterns of injury seen on neonatal MRI after neonatal encephalopathy can still be recognized on childhood MRI. Children with moderate to severe brain lesions on neonatal or childhood MRI significantly more often have impaired motor and cognitive outcomes.</abstract><cop>Maryland Heights, MO</cop><pub>Mosby, Inc</pub><pmid>20381069</pmid><doi>10.1016/j.jpeds.2010.02.016</doi><tpages>7</tpages></addata></record> |
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subjects | Asphyxia Neonatorum - physiopathology Biological and medical sciences Brain Diseases - diagnosis Brain Diseases - physiopathology Brain Injuries - diagnosis Brain Injuries - physiopathology Case-Control Studies Cerebral Palsy - diagnosis Child Female General aspects Humans Infant, Newborn Intelligence Tests Magnetic Resonance Imaging - methods Male Medical sciences Pediatrics Risk Treatment Outcome |
title | Serial MRI and Neurodevelopmental Outcome in 9- to 10-Year-Old Children with Neonatal Encephalopathy |
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