Nucleophosmin, p53, and Ki-67 expression patterns on an oral squamous cell carcinoma tissue microarray
Summary Oral cancer is the eighth most prevalent cancer worldwide. It causes significant mortality and morbidity rates, which have motivated the search for prognostic factors to better tailor the individual management of oral squamous cell carcinoma patients. Nucleophosmin is a multifunctional prote...
Gespeichert in:
| Veröffentlicht in: | Human pathology 2010-08, Vol.41 (8), p.1079-1086 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1086 |
|---|---|
| container_issue | 8 |
| container_start_page | 1079 |
| container_title | Human pathology |
| container_volume | 41 |
| creator | Coutinho-Camillo, Cláudia Malheiros, PhD Lourenço, Silvia Vanessa, PhD Nishimoto, Inês Nobuko, PhD Kowalski, Luiz Paulo, MD, PhD Soares, Fernando Augusto, MD, PhD |
| description | Summary Oral cancer is the eighth most prevalent cancer worldwide. It causes significant mortality and morbidity rates, which have motivated the search for prognostic factors to better tailor the individual management of oral squamous cell carcinoma patients. Nucleophosmin is a multifunctional protein that is involved in many cellular activities, such as, regulation of the tumor suppressor genes TP53 and p14ARF and is associated with proliferative and growth suppressive roles in the cell. Nucleophosmin is overexpressed in many solid tumors in human, including tumors of the colon, liver, stomach, ovary, and prostate. In this study, we analyzed the expression of nucleophosmin, Ki-67, and p53 by immunohistochemistry in oral squamous cell carcinomas. Less than 10% of nuclear staining was observed in 90.3%, 50.6%, and 65.3% of the cases for nucleophosmin, p53, and Ki-67, respectively. Expression of p53 was not significantly associated with any of the clinicopathologic parameters analyzed. Increased expression of Ki-67 was associated with the presence of lymph node metastasis ( P < .0001), advanced stages of disease ( P = .0030), tumors occurring in the floor of mouth ( P = .0018), and moderately/well-differentiated tumors ( P = .0287). Local recurrence was associated with higher expression of nucleophosmin ( P = .0233), and disease-free survival rate was significantly better in patients with low expression of nucleophosmin. Multivariate analysis suggested that expression of nucleophosmin could be an independent prognostic factor for oral squamous cell carcinoma patients. |
| doi_str_mv | 10.1016/j.humpath.2009.12.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754566615</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0046817710000158</els_id><sourcerecordid>733596838</sourcerecordid><originalsourceid>FETCH-LOGICAL-c575t-4d8b3fa883b7962f40c26133bb471cf74aac5a90f811f9db0cb5affa5a7860d73</originalsourceid><addsrcrecordid>eNqFkstu1DAUhi0EokPhEUCWEGLTDHYcX7IpQhU3UcECWFsnjq3xkNipnSDm7XE0A5W6qTfHi-9c_vMfhJ5TsqWEijf77W4ZJ5h325qQdkvrLaHkAdpQzupKsbZ-iDaENKJSVMoz9CTnPSGU8oY_Rmc1YUwJKjfIfV3MYOO0i3n04QJPnF1gCD3-4ishsf0zJZuzjwGXXrNNIePyh4BjggHnmwXGuGRs7DBgA8n4EEfAs895sXj0JkVICQ5P0SMHQ7bPTvEc_fzw_sfVp-r628fPV--uK8Mln6umVx1zoBTrZCtq1xBTC8pY1zWSGicbAMOhJU5R6tq-I6bj4BxwkEqQXrJz9PpYd0rxZrF51qPP63AQbJlTy6JfCFGWdC_JGG-FYqqQL--Q-7ikUGRoSlijlCKcFYofqSI552SdnpIfIR0KpFfH9F6fHNOrY5rWujhW8l6cqi_daPv_Wf8sKsCrEwDZwOASBOPzLccIb-tmFfT2yNmy39_eJp2Nt8HY3idrZt1Hf-8ol3cqmMEHX5r-sgebb1XrXBL09_W81uuipDzKFfsLxWjLEw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1034888053</pqid></control><display><type>article</type><title>Nucleophosmin, p53, and Ki-67 expression patterns on an oral squamous cell carcinoma tissue microarray</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Coutinho-Camillo, Cláudia Malheiros, PhD ; Lourenço, Silvia Vanessa, PhD ; Nishimoto, Inês Nobuko, PhD ; Kowalski, Luiz Paulo, MD, PhD ; Soares, Fernando Augusto, MD, PhD</creator><creatorcontrib>Coutinho-Camillo, Cláudia Malheiros, PhD ; Lourenço, Silvia Vanessa, PhD ; Nishimoto, Inês Nobuko, PhD ; Kowalski, Luiz Paulo, MD, PhD ; Soares, Fernando Augusto, MD, PhD</creatorcontrib><description>Summary Oral cancer is the eighth most prevalent cancer worldwide. It causes significant mortality and morbidity rates, which have motivated the search for prognostic factors to better tailor the individual management of oral squamous cell carcinoma patients. Nucleophosmin is a multifunctional protein that is involved in many cellular activities, such as, regulation of the tumor suppressor genes TP53 and p14ARF and is associated with proliferative and growth suppressive roles in the cell. Nucleophosmin is overexpressed in many solid tumors in human, including tumors of the colon, liver, stomach, ovary, and prostate. In this study, we analyzed the expression of nucleophosmin, Ki-67, and p53 by immunohistochemistry in oral squamous cell carcinomas. Less than 10% of nuclear staining was observed in 90.3%, 50.6%, and 65.3% of the cases for nucleophosmin, p53, and Ki-67, respectively. Expression of p53 was not significantly associated with any of the clinicopathologic parameters analyzed. Increased expression of Ki-67 was associated with the presence of lymph node metastasis ( P < .0001), advanced stages of disease ( P = .0030), tumors occurring in the floor of mouth ( P = .0018), and moderately/well-differentiated tumors ( P = .0287). Local recurrence was associated with higher expression of nucleophosmin ( P = .0233), and disease-free survival rate was significantly better in patients with low expression of nucleophosmin. Multivariate analysis suggested that expression of nucleophosmin could be an independent prognostic factor for oral squamous cell carcinoma patients.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2009.12.010</identifier><identifier>PMID: 20338617</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Apoptosis ; Automation ; Biological and medical sciences ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - mortality ; Cell cycle ; Cloning ; Confidence intervals ; Disease-Free Survival ; Female ; Genes ; Head & neck cancer ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Ki-67 ; Ki-67 Antigen - biosynthesis ; Ki-67 Antigen - genetics ; Leukemia ; Male ; Medical sciences ; Middle Aged ; Mortality ; Mouth Neoplasms - genetics ; Mouth Neoplasms - mortality ; Multivariate analysis ; Mutation ; Neoplasm Recurrence, Local - physiopathology ; Nuclear Proteins - biosynthesis ; Nuclear Proteins - genetics ; Nucleophosmin ; Oral cancer ; Oral squamous cell carcinoma ; Otorhinolaryngology. Stomatology ; p53 ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Prognosis ; Proteins ; Skin cancer ; Tissue microarray ; Tumor Suppressor Protein p53 - biosynthesis ; Tumor Suppressor Protein p53 - genetics ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Human pathology, 2010-08, Vol.41 (8), p.1079-1086</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-4d8b3fa883b7962f40c26133bb471cf74aac5a90f811f9db0cb5affa5a7860d73</citedby><cites>FETCH-LOGICAL-c575t-4d8b3fa883b7962f40c26133bb471cf74aac5a90f811f9db0cb5affa5a7860d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humpath.2009.12.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23059245$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20338617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coutinho-Camillo, Cláudia Malheiros, PhD</creatorcontrib><creatorcontrib>Lourenço, Silvia Vanessa, PhD</creatorcontrib><creatorcontrib>Nishimoto, Inês Nobuko, PhD</creatorcontrib><creatorcontrib>Kowalski, Luiz Paulo, MD, PhD</creatorcontrib><creatorcontrib>Soares, Fernando Augusto, MD, PhD</creatorcontrib><title>Nucleophosmin, p53, and Ki-67 expression patterns on an oral squamous cell carcinoma tissue microarray</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary Oral cancer is the eighth most prevalent cancer worldwide. It causes significant mortality and morbidity rates, which have motivated the search for prognostic factors to better tailor the individual management of oral squamous cell carcinoma patients. Nucleophosmin is a multifunctional protein that is involved in many cellular activities, such as, regulation of the tumor suppressor genes TP53 and p14ARF and is associated with proliferative and growth suppressive roles in the cell. Nucleophosmin is overexpressed in many solid tumors in human, including tumors of the colon, liver, stomach, ovary, and prostate. In this study, we analyzed the expression of nucleophosmin, Ki-67, and p53 by immunohistochemistry in oral squamous cell carcinomas. Less than 10% of nuclear staining was observed in 90.3%, 50.6%, and 65.3% of the cases for nucleophosmin, p53, and Ki-67, respectively. Expression of p53 was not significantly associated with any of the clinicopathologic parameters analyzed. Increased expression of Ki-67 was associated with the presence of lymph node metastasis ( P < .0001), advanced stages of disease ( P = .0030), tumors occurring in the floor of mouth ( P = .0018), and moderately/well-differentiated tumors ( P = .0287). Local recurrence was associated with higher expression of nucleophosmin ( P = .0233), and disease-free survival rate was significantly better in patients with low expression of nucleophosmin. Multivariate analysis suggested that expression of nucleophosmin could be an independent prognostic factor for oral squamous cell carcinoma patients.</description><subject>Apoptosis</subject><subject>Automation</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Cell cycle</subject><subject>Cloning</subject><subject>Confidence intervals</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Genes</subject><subject>Head & neck cancer</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Ki-67</subject><subject>Ki-67 Antigen - biosynthesis</subject><subject>Ki-67 Antigen - genetics</subject><subject>Leukemia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - mortality</subject><subject>Multivariate analysis</subject><subject>Mutation</subject><subject>Neoplasm Recurrence, Local - physiopathology</subject><subject>Nuclear Proteins - biosynthesis</subject><subject>Nuclear Proteins - genetics</subject><subject>Nucleophosmin</subject><subject>Oral cancer</subject><subject>Oral squamous cell carcinoma</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>p53</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Skin cancer</subject><subject>Tissue microarray</subject><subject>Tumor Suppressor Protein p53 - biosynthesis</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkstu1DAUhi0EokPhEUCWEGLTDHYcX7IpQhU3UcECWFsnjq3xkNipnSDm7XE0A5W6qTfHi-9c_vMfhJ5TsqWEijf77W4ZJ5h325qQdkvrLaHkAdpQzupKsbZ-iDaENKJSVMoz9CTnPSGU8oY_Rmc1YUwJKjfIfV3MYOO0i3n04QJPnF1gCD3-4ishsf0zJZuzjwGXXrNNIePyh4BjggHnmwXGuGRs7DBgA8n4EEfAs895sXj0JkVICQ5P0SMHQ7bPTvEc_fzw_sfVp-r628fPV--uK8Mln6umVx1zoBTrZCtq1xBTC8pY1zWSGicbAMOhJU5R6tq-I6bj4BxwkEqQXrJz9PpYd0rxZrF51qPP63AQbJlTy6JfCFGWdC_JGG-FYqqQL--Q-7ikUGRoSlijlCKcFYofqSI552SdnpIfIR0KpFfH9F6fHNOrY5rWujhW8l6cqi_daPv_Wf8sKsCrEwDZwOASBOPzLccIb-tmFfT2yNmy39_eJp2Nt8HY3idrZt1Hf-8ol3cqmMEHX5r-sgebb1XrXBL09_W81uuipDzKFfsLxWjLEw</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Coutinho-Camillo, Cláudia Malheiros, PhD</creator><creator>Lourenço, Silvia Vanessa, PhD</creator><creator>Nishimoto, Inês Nobuko, PhD</creator><creator>Kowalski, Luiz Paulo, MD, PhD</creator><creator>Soares, Fernando Augusto, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>7QO</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20100801</creationdate><title>Nucleophosmin, p53, and Ki-67 expression patterns on an oral squamous cell carcinoma tissue microarray</title><author>Coutinho-Camillo, Cláudia Malheiros, PhD ; Lourenço, Silvia Vanessa, PhD ; Nishimoto, Inês Nobuko, PhD ; Kowalski, Luiz Paulo, MD, PhD ; Soares, Fernando Augusto, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-4d8b3fa883b7962f40c26133bb471cf74aac5a90f811f9db0cb5affa5a7860d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Apoptosis</topic><topic>Automation</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Cell cycle</topic><topic>Cloning</topic><topic>Confidence intervals</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Genes</topic><topic>Head & neck cancer</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Ki-67</topic><topic>Ki-67 Antigen - biosynthesis</topic><topic>Ki-67 Antigen - genetics</topic><topic>Leukemia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - mortality</topic><topic>Multivariate analysis</topic><topic>Mutation</topic><topic>Neoplasm Recurrence, Local - physiopathology</topic><topic>Nuclear Proteins - biosynthesis</topic><topic>Nuclear Proteins - genetics</topic><topic>Nucleophosmin</topic><topic>Oral cancer</topic><topic>Oral squamous cell carcinoma</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>p53</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Skin cancer</topic><topic>Tissue microarray</topic><topic>Tumor Suppressor Protein p53 - biosynthesis</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coutinho-Camillo, Cláudia Malheiros, PhD</creatorcontrib><creatorcontrib>Lourenço, Silvia Vanessa, PhD</creatorcontrib><creatorcontrib>Nishimoto, Inês Nobuko, PhD</creatorcontrib><creatorcontrib>Kowalski, Luiz Paulo, MD, PhD</creatorcontrib><creatorcontrib>Soares, Fernando Augusto, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coutinho-Camillo, Cláudia Malheiros, PhD</au><au>Lourenço, Silvia Vanessa, PhD</au><au>Nishimoto, Inês Nobuko, PhD</au><au>Kowalski, Luiz Paulo, MD, PhD</au><au>Soares, Fernando Augusto, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleophosmin, p53, and Ki-67 expression patterns on an oral squamous cell carcinoma tissue microarray</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>41</volume><issue>8</issue><spage>1079</spage><epage>1086</epage><pages>1079-1086</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary Oral cancer is the eighth most prevalent cancer worldwide. It causes significant mortality and morbidity rates, which have motivated the search for prognostic factors to better tailor the individual management of oral squamous cell carcinoma patients. Nucleophosmin is a multifunctional protein that is involved in many cellular activities, such as, regulation of the tumor suppressor genes TP53 and p14ARF and is associated with proliferative and growth suppressive roles in the cell. Nucleophosmin is overexpressed in many solid tumors in human, including tumors of the colon, liver, stomach, ovary, and prostate. In this study, we analyzed the expression of nucleophosmin, Ki-67, and p53 by immunohistochemistry in oral squamous cell carcinomas. Less than 10% of nuclear staining was observed in 90.3%, 50.6%, and 65.3% of the cases for nucleophosmin, p53, and Ki-67, respectively. Expression of p53 was not significantly associated with any of the clinicopathologic parameters analyzed. Increased expression of Ki-67 was associated with the presence of lymph node metastasis ( P < .0001), advanced stages of disease ( P = .0030), tumors occurring in the floor of mouth ( P = .0018), and moderately/well-differentiated tumors ( P = .0287). Local recurrence was associated with higher expression of nucleophosmin ( P = .0233), and disease-free survival rate was significantly better in patients with low expression of nucleophosmin. Multivariate analysis suggested that expression of nucleophosmin could be an independent prognostic factor for oral squamous cell carcinoma patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20338617</pmid><doi>10.1016/j.humpath.2009.12.010</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0046-8177 |
| ispartof | Human pathology, 2010-08, Vol.41 (8), p.1079-1086 |
| issn | 0046-8177 1532-8392 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_754566615 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Apoptosis Automation Biological and medical sciences Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - mortality Cell cycle Cloning Confidence intervals Disease-Free Survival Female Genes Head & neck cancer Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Ki-67 Ki-67 Antigen - biosynthesis Ki-67 Antigen - genetics Leukemia Male Medical sciences Middle Aged Mortality Mouth Neoplasms - genetics Mouth Neoplasms - mortality Multivariate analysis Mutation Neoplasm Recurrence, Local - physiopathology Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Nucleophosmin Oral cancer Oral squamous cell carcinoma Otorhinolaryngology. Stomatology p53 Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis Proteins Skin cancer Tissue microarray Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Nucleophosmin, p53, and Ki-67 expression patterns on an oral squamous cell carcinoma tissue microarray |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T23%3A46%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nucleophosmin,%20p53,%20and%20Ki-67%20expression%20patterns%20on%20an%20oral%20squamous%20cell%20carcinoma%20tissue%20microarray&rft.jtitle=Human%20pathology&rft.au=Coutinho-Camillo,%20Cl%C3%A1udia%20Malheiros,%20PhD&rft.date=2010-08-01&rft.volume=41&rft.issue=8&rft.spage=1079&rft.epage=1086&rft.pages=1079-1086&rft.issn=0046-8177&rft.eissn=1532-8392&rft.coden=HPCQA4&rft_id=info:doi/10.1016/j.humpath.2009.12.010&rft_dat=%3Cproquest_cross%3E733596838%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1034888053&rft_id=info:pmid/20338617&rft_els_id=1_s2_0_S0046817710000158&rfr_iscdi=true |