Multidetector-row computed tomography of the coronary arteries: predictive value and quantitative assessment of non-calcified vessel-wall changes
The aim of this study was to quantitatively assess non-calcified coronary artery plaques and to determine their predictive value for the detection of coronary artery disease (CAD). A total of 179 patients underwent a calcium screening examination and a contrast-enhanced multidetector-row computed to...
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| Veröffentlicht in: | European radiology 2003-11, Vol.13 (11), p.2505-2512 |
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| creator | Nikolaou, Konstantin Sagmeister, Sonja Knez, Andreas Klotz, Ernst Wintersperger, Bernd J Becker, Christoph R Reiser, Maximilian F |
| description | The aim of this study was to quantitatively assess non-calcified coronary artery plaques and to determine their predictive value for the detection of coronary artery disease (CAD). A total of 179 patients underwent a calcium screening examination and a contrast-enhanced multidetector-row computed tomography angiography (MDCT) of the coronary arteries for various indications. The traditional calcium scores were evaluated and all examinations were reviewed for the presence of non-calcified plaques with an attenuation of 0-130 Hounsfield units (HU). The number, mean attenuation, and volume of these non-calcified plaques were recorded. All patients also underwent conventional catheter angiography. Coronary calcium was detected in 73% (131 of 179) of the patients. Overall incidence of purely non-calcified plaques was 30% (53 of 179). In 27% of the patients (48 of 179) no calcium was detected; however, 15% of these patients without calcifications showed non-calcified plaques (7 of 48). Significant correlations were found between the volume of calcified plaques, volume of non-calcified plaques, and total plaque volume. There were significant differences in plaque composition comparing different risk factor profiles and different stages of CAD. Volumetric assessment of non-calcified coronary artery plaques is feasible using contrast-enhanced MDCT. Screening for non-calcified plaques identifies patients with signs of CAD that are missed in a calcium screening examination. |
| doi_str_mv | 10.1007/s00330-003-2053-y |
| format | Article |
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A total of 179 patients underwent a calcium screening examination and a contrast-enhanced multidetector-row computed tomography angiography (MDCT) of the coronary arteries for various indications. The traditional calcium scores were evaluated and all examinations were reviewed for the presence of non-calcified plaques with an attenuation of 0-130 Hounsfield units (HU). The number, mean attenuation, and volume of these non-calcified plaques were recorded. All patients also underwent conventional catheter angiography. Coronary calcium was detected in 73% (131 of 179) of the patients. Overall incidence of purely non-calcified plaques was 30% (53 of 179). In 27% of the patients (48 of 179) no calcium was detected; however, 15% of these patients without calcifications showed non-calcified plaques (7 of 48). Significant correlations were found between the volume of calcified plaques, volume of non-calcified plaques, and total plaque volume. There were significant differences in plaque composition comparing different risk factor profiles and different stages of CAD. Volumetric assessment of non-calcified coronary artery plaques is feasible using contrast-enhanced MDCT. Screening for non-calcified plaques identifies patients with signs of CAD that are missed in a calcium screening examination.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-003-2053-y</identifier><identifier>PMID: 12920562</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Calcinosis - diagnostic imaging ; Calcinosis - pathology ; Cardiovascular disease ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - pathology ; Female ; Humans ; Incidence ; Male ; Medical imaging ; Middle Aged ; Predictive Value of Tests ; Risk Factors ; Severity of Illness Index ; Tomography, X-Ray Computed - methods</subject><ispartof>European radiology, 2003-11, Vol.13 (11), p.2505-2512</ispartof><rights>Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-d15c180a0374690be3febf32b7871d020a5a37e66b0b73538033f030d82d356e3</citedby><cites>FETCH-LOGICAL-c356t-d15c180a0374690be3febf32b7871d020a5a37e66b0b73538033f030d82d356e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12920562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nikolaou, Konstantin</creatorcontrib><creatorcontrib>Sagmeister, Sonja</creatorcontrib><creatorcontrib>Knez, Andreas</creatorcontrib><creatorcontrib>Klotz, Ernst</creatorcontrib><creatorcontrib>Wintersperger, Bernd J</creatorcontrib><creatorcontrib>Becker, Christoph R</creatorcontrib><creatorcontrib>Reiser, Maximilian F</creatorcontrib><title>Multidetector-row computed tomography of the coronary arteries: predictive value and quantitative assessment of non-calcified vessel-wall changes</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>The aim of this study was to quantitatively assess non-calcified coronary artery plaques and to determine their predictive value for the detection of coronary artery disease (CAD). A total of 179 patients underwent a calcium screening examination and a contrast-enhanced multidetector-row computed tomography angiography (MDCT) of the coronary arteries for various indications. The traditional calcium scores were evaluated and all examinations were reviewed for the presence of non-calcified plaques with an attenuation of 0-130 Hounsfield units (HU). The number, mean attenuation, and volume of these non-calcified plaques were recorded. All patients also underwent conventional catheter angiography. Coronary calcium was detected in 73% (131 of 179) of the patients. Overall incidence of purely non-calcified plaques was 30% (53 of 179). In 27% of the patients (48 of 179) no calcium was detected; however, 15% of these patients without calcifications showed non-calcified plaques (7 of 48). Significant correlations were found between the volume of calcified plaques, volume of non-calcified plaques, and total plaque volume. There were significant differences in plaque composition comparing different risk factor profiles and different stages of CAD. Volumetric assessment of non-calcified coronary artery plaques is feasible using contrast-enhanced MDCT. Screening for non-calcified plaques identifies patients with signs of CAD that are missed in a calcium screening examination.</description><subject>Calcinosis - diagnostic imaging</subject><subject>Calcinosis - pathology</subject><subject>Cardiovascular disease</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc9u1DAQxi1ERZfCA3BBFgc4uYztOE64VRX_pCIucLYcZ9JNldip7Wy1j9E3rpddCYkDlxlp5vd9lucj5A2HSw6gPyYAKYGVygQoyfbPyIZXUjAOTfWcbKCVDdNtW52TlyndAUDLK_2CnHPRFkEtNuTxxzrlsceMLofIYnigLszLmrGnOczhNtplu6dhoHmLZRWDt3FPbcwYR0yf6BKxH10ed0h3dlqRWt_T-9X6PGb7Z2xTwpRm9Plg44Nnzk5uHMbyxK5scGIPdpqo21p_i-kVORvslPD1qV-Q318-_7r-xm5-fv1-fXXDnFR1Zj1XjjdgQeqqbqFDOWA3SNHpRvMeBFhlpca67qDTUsmmnGoACX0j-mKA8oJ8OPouMdyvmLKZx-RwmqzHsCajVaXqWtW8kO__T3IJvFKqgO_-Ae_CGn35hSk2WgjNmwLxI-RiSCniYJY4zuWohoM5xGqOsZpSzSFWsy-atyfjtZux_6s45SifAI0IoDE</recordid><startdate>200311</startdate><enddate>200311</enddate><creator>Nikolaou, Konstantin</creator><creator>Sagmeister, Sonja</creator><creator>Knez, Andreas</creator><creator>Klotz, Ernst</creator><creator>Wintersperger, Bernd J</creator><creator>Becker, Christoph R</creator><creator>Reiser, Maximilian F</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>200311</creationdate><title>Multidetector-row computed tomography of the coronary arteries: predictive value and quantitative assessment of non-calcified vessel-wall changes</title><author>Nikolaou, Konstantin ; Sagmeister, Sonja ; Knez, Andreas ; Klotz, Ernst ; Wintersperger, Bernd J ; Becker, Christoph R ; Reiser, Maximilian F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-d15c180a0374690be3febf32b7871d020a5a37e66b0b73538033f030d82d356e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Calcinosis - diagnostic imaging</topic><topic>Calcinosis - pathology</topic><topic>Cardiovascular disease</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nikolaou, Konstantin</creatorcontrib><creatorcontrib>Sagmeister, Sonja</creatorcontrib><creatorcontrib>Knez, Andreas</creatorcontrib><creatorcontrib>Klotz, Ernst</creatorcontrib><creatorcontrib>Wintersperger, Bernd J</creatorcontrib><creatorcontrib>Becker, Christoph R</creatorcontrib><creatorcontrib>Reiser, Maximilian F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nikolaou, Konstantin</au><au>Sagmeister, Sonja</au><au>Knez, Andreas</au><au>Klotz, Ernst</au><au>Wintersperger, Bernd J</au><au>Becker, Christoph R</au><au>Reiser, Maximilian F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multidetector-row computed tomography of the coronary arteries: predictive value and quantitative assessment of non-calcified vessel-wall changes</atitle><jtitle>European radiology</jtitle><addtitle>Eur Radiol</addtitle><date>2003-11</date><risdate>2003</risdate><volume>13</volume><issue>11</issue><spage>2505</spage><epage>2512</epage><pages>2505-2512</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>The aim of this study was to quantitatively assess non-calcified coronary artery plaques and to determine their predictive value for the detection of coronary artery disease (CAD). A total of 179 patients underwent a calcium screening examination and a contrast-enhanced multidetector-row computed tomography angiography (MDCT) of the coronary arteries for various indications. The traditional calcium scores were evaluated and all examinations were reviewed for the presence of non-calcified plaques with an attenuation of 0-130 Hounsfield units (HU). The number, mean attenuation, and volume of these non-calcified plaques were recorded. All patients also underwent conventional catheter angiography. Coronary calcium was detected in 73% (131 of 179) of the patients. Overall incidence of purely non-calcified plaques was 30% (53 of 179). In 27% of the patients (48 of 179) no calcium was detected; however, 15% of these patients without calcifications showed non-calcified plaques (7 of 48). Significant correlations were found between the volume of calcified plaques, volume of non-calcified plaques, and total plaque volume. There were significant differences in plaque composition comparing different risk factor profiles and different stages of CAD. Volumetric assessment of non-calcified coronary artery plaques is feasible using contrast-enhanced MDCT. Screening for non-calcified plaques identifies patients with signs of CAD that are missed in a calcium screening examination.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>12920562</pmid><doi>10.1007/s00330-003-2053-y</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Calcinosis - diagnostic imaging Calcinosis - pathology Cardiovascular disease Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Coronary Artery Disease - pathology Female Humans Incidence Male Medical imaging Middle Aged Predictive Value of Tests Risk Factors Severity of Illness Index Tomography, X-Ray Computed - methods |
| title | Multidetector-row computed tomography of the coronary arteries: predictive value and quantitative assessment of non-calcified vessel-wall changes |
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