Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses

Abstract Immunization against conserved virus components induces broad, heterosubtypic protection against diverse influenza A viruses, providing a strategy for controlling unexpected outbreaks or pandemics until strain-matched vaccines become available. This study characterized immunization to nucle...

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Veröffentlicht in:	Vaccine 2009-11, Vol.27 (47), p.6512-6521
Hauptverfasser:	Price, Graeme E, Soboleski, Mark R, Lo, Chia-Yun, Misplon, Julia A, Pappas, Claudia, Houser, Katherine V, Tumpey, Terrence M, Epstein, Suzanne L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Adenoviruses Allergy and Immunology Animals Antibodies, Viral - blood Applied microbiology Avian flu Biological and medical sciences Catheters Cold-adapted Deoxyribonucleic acid DNA DNA vaccine Experiments Female Ferret Ferrets Fundamental and applied biological sciences. Psychology H5N1 Heterosubtypic immunity Immune response Immunity, Mucosal Immunization Immunization, Secondary Immunoglobulin A - blood Immunologic Memory Infections Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - immunology Influenza virus Intramuscular Intranasal Male Mice Mice, Inbred BALB C Microbiology Miscellaneous Mustela Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Pandemic Pandemics Peptides Prime-boost Public health Recombinant adenovirus RNA-Binding Proteins - immunology Systemic T-Lymphocytes - immunology Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral Core Proteins - immunology Viral Matrix Proteins - immunology Virology Viruses
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