Respiratory syncytial virus subunit vaccine based on a recombinant fusion protein expressed transiently in mammalian cells

Abstract Although respiratory syncytial virus (RSV) causes severe lower respiratory tract infection in infants and adults at risk, no RSV vaccine is currently available. In this report, efforts toward the generation of an RSV subunit vaccine using recombinant RSV fusion protein (rRSV-F) are describe...

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Veröffentlicht in:	Vaccine 2009-10, Vol.27 (46), p.6415-6419
Hauptverfasser:	Nallet, Sophie, Amacker, Mario, Westerfeld, Nicole, Baldi, Lucia, König, Iwo, Hacker, David L, Zaborosch, Christiane, Zurbriggen, Rinaldo, Wurm, Florian M
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies Antibodies, Viral - blood Bioreactors Cell culture Cell Line Clinical trials Deoxyribonucleic acid DNA Fusion protein Gene expression Humans Infants Infection Influenza Mammalian cells Mammals Mice Mice, Inbred BALB C Neutralization Tests Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - isolation & purification Recombinant protein Regulatory approval Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - prevention & control Respiratory Syncytial Virus Vaccines - immunology Respiratory tract Respiratory tract diseases RSV vaccine Transfection Transient transfection Vaccines Vaccines, Subunit - immunology Viral Fusion Proteins - genetics Viral Fusion Proteins - immunology Viral Fusion Proteins - isolation & purification Virosomes Virosomes - immunology
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