Structural basis for oseltamivir resistance of influenza viruses

Abstract Oseltamivir, one of the two anti-neuraminidase drugs, is currently the most widely used drug against influenza. Resistance to the drug has occurred infrequently among different viruses in response to drug treatment, including A H5N1 viruses, but most notably has emerged among recently circu...

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Veröffentlicht in:	Vaccine 2009-10, Vol.27 (45), p.6317-6323
Hauptverfasser:	Collins, P.J, Haire, L.F, Lin, Y.P, Liu, J, Russell, R.J, Walker, P.A, Martin, S.R, Daniels, R.S, Gregory, V, Skehel, J.J, Gamblin, S.J, Hay, A.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Avian flu Crystal structure Drug resistance Drug Resistance, Viral Drugs Enzymes Exo-a-sialidase H275Y mutation Influenza A Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - drug effects Influenza A Virus, H5N1 Subtype - genetics Influenza H5N1 Models, Molecular Mutation Neuraminidase - genetics Oseltamivir Oseltamivir - chemistry Oseltamivir - pharmacology Oseltamivir resistance Protein Structure, Tertiary Studies Swine flu Viral Proteins - genetics Viruses Zanamivir
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