IgG responses after booster vaccination with different pertussis vaccines in Dutch children 4 years of age: Effect of vaccine antigen content
Abstract Since whooping cough is reemerging in the Netherlands from 1996 onwards, several changes in the national immunization program have been implemented regarding the pertussis vaccinations. The aim of this study is to investigate IgG responses in whole cell (wP) and acellular (aP) pertussis vac...
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| Veröffentlicht in: | Vaccine 2009-11, Vol.27 (47), p.6530-6536 |
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| creator | Hendrikx, Lotte H Berbers, Guy A.M Veenhoven, Reinier H Sanders, Elisabeth A.M Buisman, Anne-Marie |
| description | Abstract Since whooping cough is reemerging in the Netherlands from 1996 onwards, several changes in the national immunization program have been implemented regarding the pertussis vaccinations. The aim of this study is to investigate IgG responses in whole cell (wP) and acellular (aP) pertussis vaccine primed children following revaccination with different pertussis booster vaccines at 4 years of age. IgG levels to pertussis toxin (Pt), filamentous heamagglutin (FHA), pertactin (Prn) and fimbriae type 2 and 3 (Fim2/3) and avidities of Pt and Prn antibodies were measured using a multiplex immunoassay. Before and after the booster we found significantly higher IgG levels to Pt, FHA and Prn in aP compared to wP primed children. In all children a booster vaccination with a pertussis vaccine containing a high antigen dose ( Infanrix ™) induced higher IgG responses compared to a low antigen dose containing vaccine ( Triaxis ™). Avidities of Pt- and Prn-antibodies before and after booster vaccination were significantly higher in aP than in wP primed children. This study shows that a booster vaccine with high pertussis antigen concentrations induces higher antibody levels than a low antigen containing vaccine. In children primed with the Dutch DTwP-IPV-Hib vaccine we suggest to administer a booster vaccine containing high pertussis antigens to optimize IgG responses. The pertussis vaccination history has to be taken into account in decisions on changes in pertussis vaccination policy. |
| doi_str_mv | 10.1016/j.vaccine.2009.08.052 |
| format | Article |
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The aim of this study is to investigate IgG responses in whole cell (wP) and acellular (aP) pertussis vaccine primed children following revaccination with different pertussis booster vaccines at 4 years of age. IgG levels to pertussis toxin (Pt), filamentous heamagglutin (FHA), pertactin (Prn) and fimbriae type 2 and 3 (Fim2/3) and avidities of Pt and Prn antibodies were measured using a multiplex immunoassay. Before and after the booster we found significantly higher IgG levels to Pt, FHA and Prn in aP compared to wP primed children. In all children a booster vaccination with a pertussis vaccine containing a high antigen dose ( Infanrix ™) induced higher IgG responses compared to a low antigen dose containing vaccine ( Triaxis ™). Avidities of Pt- and Prn-antibodies before and after booster vaccination were significantly higher in aP than in wP primed children. This study shows that a booster vaccine with high pertussis antigen concentrations induces higher antibody levels than a low antigen containing vaccine. In children primed with the Dutch DTwP-IPV-Hib vaccine we suggest to administer a booster vaccine containing high pertussis antigens to optimize IgG responses. The pertussis vaccination history has to be taken into account in decisions on changes in pertussis vaccination policy.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2009.08.052</identifier><identifier>PMID: 19729085</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Age ; Allergy and Immunology ; Antibodies ; Antibodies, Bacterial - blood ; Antibody Affinity ; Antigens ; Applied microbiology ; Bacterial diseases ; Biological and medical sciences ; Booster response ; Bordetella pertussis - immunology ; Child, Preschool ; Children & youth ; Confidence intervals ; Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology ; Ent and stomatologic bacterial diseases ; Fundamental and applied biological sciences. Psychology ; Human bacterial diseases ; Humans ; Immunization ; Immunization, Secondary ; Immunoassay ; Immunoglobulin G - blood ; Infectious diseases ; Medical sciences ; Microbiology ; Netherlands ; Pertussis Vaccine - immunology ; Pertussis vaccines ; Studies ; Toxins ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Whooping cough ; Whooping Cough - immunology ; Whooping Cough - prevention & control</subject><ispartof>Vaccine, 2009-11, Vol.27 (47), p.6530-6536</ispartof><rights>Elsevier Ltd</rights><rights>2009 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Elsevier Limited Nov 5, 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-39c57702a68605ab2e812a69e546c185af9ba0db11429bee540316245231f9f83</citedby><cites>FETCH-LOGICAL-c509t-39c57702a68605ab2e812a69e546c185af9ba0db11429bee540316245231f9f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1618912069?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994,64384,64386,64388,72340</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22174131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19729085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hendrikx, Lotte H</creatorcontrib><creatorcontrib>Berbers, Guy A.M</creatorcontrib><creatorcontrib>Veenhoven, Reinier H</creatorcontrib><creatorcontrib>Sanders, Elisabeth A.M</creatorcontrib><creatorcontrib>Buisman, Anne-Marie</creatorcontrib><title>IgG responses after booster vaccination with different pertussis vaccines in Dutch children 4 years of age: Effect of vaccine antigen content</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Since whooping cough is reemerging in the Netherlands from 1996 onwards, several changes in the national immunization program have been implemented regarding the pertussis vaccinations. The aim of this study is to investigate IgG responses in whole cell (wP) and acellular (aP) pertussis vaccine primed children following revaccination with different pertussis booster vaccines at 4 years of age. IgG levels to pertussis toxin (Pt), filamentous heamagglutin (FHA), pertactin (Prn) and fimbriae type 2 and 3 (Fim2/3) and avidities of Pt and Prn antibodies were measured using a multiplex immunoassay. Before and after the booster we found significantly higher IgG levels to Pt, FHA and Prn in aP compared to wP primed children. In all children a booster vaccination with a pertussis vaccine containing a high antigen dose ( Infanrix ™) induced higher IgG responses compared to a low antigen dose containing vaccine ( Triaxis ™). Avidities of Pt- and Prn-antibodies before and after booster vaccination were significantly higher in aP than in wP primed children. This study shows that a booster vaccine with high pertussis antigen concentrations induces higher antibody levels than a low antigen containing vaccine. In children primed with the Dutch DTwP-IPV-Hib vaccine we suggest to administer a booster vaccine containing high pertussis antigens to optimize IgG responses. The pertussis vaccination history has to be taken into account in decisions on changes in pertussis vaccination policy.</description><subject>Age</subject><subject>Allergy and Immunology</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibody Affinity</subject><subject>Antigens</subject><subject>Applied microbiology</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Booster response</subject><subject>Bordetella pertussis - immunology</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Confidence intervals</subject><subject>Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology</subject><subject>Ent and stomatologic bacterial diseases</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization, Secondary</subject><subject>Immunoassay</subject><subject>Immunoglobulin G - blood</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Netherlands</subject><subject>Pertussis Vaccine - immunology</subject><subject>Pertussis vaccines</subject><subject>Studies</subject><subject>Toxins</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Whooping cough</subject><subject>Whooping Cough - immunology</subject><subject>Whooping Cough - prevention & control</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkt-K1DAUxoso7jj6CEpAxKsZz0mbtvFCkXVdFxa8UMG7kKanMxk76WySrsxD-M6mTHFhb_QqnPD7zr_vZNlzhDUClm9261ttjHW05gByDfUaBH-QLbCu8hUXWD_MFsDLYlUg_DjLnoSwAwCRo3ycnaGsuIRaLLLfV5tL5ikcBhcoMN1F8qwZhjC9pwo62sGxXzZuWWu7jjy5yA7k4xiCDTOUtNaxj2M0W2a2tm8TxQp2JO0DGzqmN_SWXSS1iVM4i5h20W4SaQYXU9qn2aNO94Geze8y-_7p4tv559X1l8ur8w_XKyNAxlUujagq4LqsSxC64VRjCiSJojRYC93JRkPbIBZcNpS-IceSF4Ln2MmuzpfZ61Pegx9uRgpR7W0w1Pfa0TAGVYlClCVW_0HmBXKs0mKX2ct75G4YvUtjKCyxlsihlIkSJ8r4IQRPnTp4u9f-qBDUZKzaqXk5ajJWQa2SsUn3Ys4-Nntq71Szkwl4NQM6GN13Xjtjw1-OpyYLzDFx708cpf3eWvIqGEvOUGt9Mke1g_1nK-_uZTC9dTYV_UlHCndTq8AVqK_TFU5HCBKQ51WV_wGGoNh9</recordid><startdate>20091105</startdate><enddate>20091105</enddate><creator>Hendrikx, Lotte H</creator><creator>Berbers, Guy A.M</creator><creator>Veenhoven, Reinier H</creator><creator>Sanders, Elisabeth A.M</creator><creator>Buisman, Anne-Marie</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20091105</creationdate><title>IgG responses after booster vaccination with different pertussis vaccines in Dutch children 4 years of age: Effect of vaccine antigen content</title><author>Hendrikx, Lotte H ; Berbers, Guy A.M ; Veenhoven, Reinier H ; Sanders, Elisabeth A.M ; Buisman, Anne-Marie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-39c57702a68605ab2e812a69e546c185af9ba0db11429bee540316245231f9f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Age</topic><topic>Allergy and Immunology</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antibody Affinity</topic><topic>Antigens</topic><topic>Applied microbiology</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Booster response</topic><topic>Bordetella pertussis - immunology</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Confidence intervals</topic><topic>Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology</topic><topic>Ent and stomatologic bacterial diseases</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization, Secondary</topic><topic>Immunoassay</topic><topic>Immunoglobulin G - blood</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Netherlands</topic><topic>Pertussis Vaccine - immunology</topic><topic>Pertussis vaccines</topic><topic>Studies</topic><topic>Toxins</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Whooping cough</topic><topic>Whooping Cough - immunology</topic><topic>Whooping Cough - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hendrikx, Lotte H</creatorcontrib><creatorcontrib>Berbers, Guy A.M</creatorcontrib><creatorcontrib>Veenhoven, Reinier H</creatorcontrib><creatorcontrib>Sanders, Elisabeth A.M</creatorcontrib><creatorcontrib>Buisman, Anne-Marie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hendrikx, Lotte H</au><au>Berbers, Guy A.M</au><au>Veenhoven, Reinier H</au><au>Sanders, Elisabeth A.M</au><au>Buisman, Anne-Marie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgG responses after booster vaccination with different pertussis vaccines in Dutch children 4 years of age: Effect of vaccine antigen content</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2009-11-05</date><risdate>2009</risdate><volume>27</volume><issue>47</issue><spage>6530</spage><epage>6536</epage><pages>6530-6536</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Abstract Since whooping cough is reemerging in the Netherlands from 1996 onwards, several changes in the national immunization program have been implemented regarding the pertussis vaccinations. The aim of this study is to investigate IgG responses in whole cell (wP) and acellular (aP) pertussis vaccine primed children following revaccination with different pertussis booster vaccines at 4 years of age. IgG levels to pertussis toxin (Pt), filamentous heamagglutin (FHA), pertactin (Prn) and fimbriae type 2 and 3 (Fim2/3) and avidities of Pt and Prn antibodies were measured using a multiplex immunoassay. Before and after the booster we found significantly higher IgG levels to Pt, FHA and Prn in aP compared to wP primed children. In all children a booster vaccination with a pertussis vaccine containing a high antigen dose ( Infanrix ™) induced higher IgG responses compared to a low antigen dose containing vaccine ( Triaxis ™). Avidities of Pt- and Prn-antibodies before and after booster vaccination were significantly higher in aP than in wP primed children. This study shows that a booster vaccine with high pertussis antigen concentrations induces higher antibody levels than a low antigen containing vaccine. In children primed with the Dutch DTwP-IPV-Hib vaccine we suggest to administer a booster vaccine containing high pertussis antigens to optimize IgG responses. The pertussis vaccination history has to be taken into account in decisions on changes in pertussis vaccination policy.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19729085</pmid><doi>10.1016/j.vaccine.2009.08.052</doi><tpages>7</tpages></addata></record> |
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| subjects | Age Allergy and Immunology Antibodies Antibodies, Bacterial - blood Antibody Affinity Antigens Applied microbiology Bacterial diseases Biological and medical sciences Booster response Bordetella pertussis - immunology Child, Preschool Children & youth Confidence intervals Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology Ent and stomatologic bacterial diseases Fundamental and applied biological sciences. Psychology Human bacterial diseases Humans Immunization Immunization, Secondary Immunoassay Immunoglobulin G - blood Infectious diseases Medical sciences Microbiology Netherlands Pertussis Vaccine - immunology Pertussis vaccines Studies Toxins Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Whooping cough Whooping Cough - immunology Whooping Cough - prevention & control |
| title | IgG responses after booster vaccination with different pertussis vaccines in Dutch children 4 years of age: Effect of vaccine antigen content |
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