Influence of human tumor suppressor PTEN on sensitivity of malignant cells to anticancer drugs

The influence of the human tumor suppressor PTEN on sensitivity of tumor cells to cytostatic drugs was studied. Rat ras-transformed (N-rasAsp12) fibroblasts were stably transfected with a full-size PTEN gene. Transfected clone was characterized by an enhanced expression of PTEN and a more normal phe...

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Veröffentlicht in:	Biochemistry (Moscow). Supplement series A, Membrane and cell biology Membrane and cell biology, 2007-06, Vol.1 (2), p.123-129
Hauptverfasser:	Shcherbakova, E. A., Stromskaya, T. P., Rybalkina, E. Yu, Stavrovskaya, A. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic drugs Antitumor agents Colchicine Drug resistance Drugs Fibroblasts Glycoproteins Molecular modelling P-Glycoprotein Phenotypes Proteins PTEN protein Sensitivity Transfection Tumor cell lines Tumor cells Tumor suppressor genes Tumors
Online-Zugang:	Volltext
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