Protection of pregnant mice, fetuses and neonates from lethality of H5N1 influenza viruses by maternal vaccination
Abstract The highly pathogenic H5N1 influenza viruses are one of candidates for the next pandemic. Information on protective immunity for pregnant animals by vaccination against the H5N1 influenza virus is limited. Here, we show that the immunization of pregnant mice with inactivated H5N1 influenza...
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| Veröffentlicht in: | Vaccine 2010-04, Vol.28 (17), p.2957-2964 |
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| creator | Hwang, Seon Do Shin, Jin Soo Ku, Keun Bon Kim, Hyun Soo Cho, Sung Whan Seo, Sang Heui |
| description | Abstract The highly pathogenic H5N1 influenza viruses are one of candidates for the next pandemic. Information on protective immunity for pregnant animals by vaccination against the H5N1 influenza virus is limited. Here, we show that the immunization of pregnant mice with inactivated H5N1 influenza vaccine protects them, their fetuses, and their infant mice from H5N1 influenza viruses. Pregnant mice immunized with two doses of H5N1 influenza vaccine were protected from homologous infections of H5N1 influenza viruses with no viruses detected in fetuses, and that they were protected upto 30% from heterologous infections of H5N1 influenza viruses with viruses detected in fetuses. The infant mice born to mothers immunized with H5N1 influenza vaccine were fully protected from infections of H5N1 influenza viruses for upto 4 weeks of age. The protection of infant mice was closely related to the presence of IgG2a antibody in lung, heart, and rectum tissues. Our results suggest that maternal vaccination may be critical for protecting pregnant animals, their fetuses, and their infant mice from lethal infections of H5N1 influenza viruses. |
| doi_str_mv | 10.1016/j.vaccine.2010.02.016 |
| format | Article |
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Information on protective immunity for pregnant animals by vaccination against the H5N1 influenza virus is limited. Here, we show that the immunization of pregnant mice with inactivated H5N1 influenza vaccine protects them, their fetuses, and their infant mice from H5N1 influenza viruses. Pregnant mice immunized with two doses of H5N1 influenza vaccine were protected from homologous infections of H5N1 influenza viruses with no viruses detected in fetuses, and that they were protected upto 30% from heterologous infections of H5N1 influenza viruses with viruses detected in fetuses. The infant mice born to mothers immunized with H5N1 influenza vaccine were fully protected from infections of H5N1 influenza viruses for upto 4 weeks of age. The protection of infant mice was closely related to the presence of IgG2a antibody in lung, heart, and rectum tissues. Our results suggest that maternal vaccination may be critical for protecting pregnant animals, their fetuses, and their infant mice from lethal infections of H5N1 influenza viruses.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2010.02.016</identifier><identifier>PMID: 20188684</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Allergy and Immunology ; Animals ; Animals, Newborn ; Antibodies, Viral - analysis ; Antibodies, Viral - blood ; Applied microbiology ; Avian flu ; Biological and medical sciences ; Blood - immunology ; Cloning ; Cross Protection ; Disease control ; Female ; Fetus ; Fetuses ; Fundamental and applied biological sciences. Psychology ; H5N1 ; Immunization ; Immunization, Secondary - methods ; Immunoglobulin G - analysis ; Immunoglobulin G - blood ; Infants ; Influenza A Virus, H5N1 Subtype - immunology ; Influenza Vaccines - immunology ; Influenza virus ; Lung - immunology ; Mice ; Mice, Inbred BALB C ; Microbiology ; Miscellaneous ; Mortality ; Myocardium - immunology ; Neonates ; Orthomyxoviridae Infections - prevention & control ; Pandemics ; Plasmids ; Pregnancy ; Rectum - immunology ; Studies ; Survival Analysis ; Time Factors ; Vaccination - methods ; Vaccine ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, Inactivated - immunology ; Virology ; Viruses ; Womens health</subject><ispartof>Vaccine, 2010-04, Vol.28 (17), p.2957-2964</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 9, 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-b763bf0c4b89c94c88c0838bf8b09669449c37d30bd3dc342689cbf89b8dea143</citedby><cites>FETCH-LOGICAL-c509t-b763bf0c4b89c94c88c0838bf8b09669449c37d30bd3dc342689cbf89b8dea143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1498115340?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22602824$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20188684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Seon Do</creatorcontrib><creatorcontrib>Shin, Jin Soo</creatorcontrib><creatorcontrib>Ku, Keun Bon</creatorcontrib><creatorcontrib>Kim, Hyun Soo</creatorcontrib><creatorcontrib>Cho, Sung Whan</creatorcontrib><creatorcontrib>Seo, Sang Heui</creatorcontrib><title>Protection of pregnant mice, fetuses and neonates from lethality of H5N1 influenza viruses by maternal vaccination</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract The highly pathogenic H5N1 influenza viruses are one of candidates for the next pandemic. Information on protective immunity for pregnant animals by vaccination against the H5N1 influenza virus is limited. Here, we show that the immunization of pregnant mice with inactivated H5N1 influenza vaccine protects them, their fetuses, and their infant mice from H5N1 influenza viruses. Pregnant mice immunized with two doses of H5N1 influenza vaccine were protected from homologous infections of H5N1 influenza viruses with no viruses detected in fetuses, and that they were protected upto 30% from heterologous infections of H5N1 influenza viruses with viruses detected in fetuses. The infant mice born to mothers immunized with H5N1 influenza vaccine were fully protected from infections of H5N1 influenza viruses for upto 4 weeks of age. The protection of infant mice was closely related to the presence of IgG2a antibody in lung, heart, and rectum tissues. Our results suggest that maternal vaccination may be critical for protecting pregnant animals, their fetuses, and their infant mice from lethal infections of H5N1 influenza viruses.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antibodies, Viral - analysis</subject><subject>Antibodies, Viral - blood</subject><subject>Applied microbiology</subject><subject>Avian flu</subject><subject>Biological and medical sciences</subject><subject>Blood - immunology</subject><subject>Cloning</subject><subject>Cross Protection</subject><subject>Disease control</subject><subject>Female</subject><subject>Fetus</subject><subject>Fetuses</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>H5N1</subject><subject>Immunization</subject><subject>Immunization, Secondary - methods</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin G - blood</subject><subject>Infants</subject><subject>Influenza A Virus, H5N1 Subtype - immunology</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza virus</subject><subject>Lung - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mortality</subject><subject>Myocardium - immunology</subject><subject>Neonates</subject><subject>Orthomyxoviridae Infections - prevention & control</subject><subject>Pandemics</subject><subject>Plasmids</subject><subject>Pregnancy</subject><subject>Rectum - immunology</subject><subject>Studies</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><subject>Vaccination - methods</subject><subject>Vaccine</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, Inactivated - immunology</subject><subject>Virology</subject><subject>Viruses</subject><subject>Womens health</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkl1rFDEUhoNY7Lb6E5SASG-cNd-b3FSkaFsoKqjgXchkzmjWmcyazCysv74Zd7XQm16FnDzv-ch7EHpOyZISqt6sl1vnfYiwZKTECFuW6CO0oHrFKyapfowWhClRCUq-H6OTnNeEEMmpeYKOi0RrpcUCpc9pGMGPYYh4aPEmwY_o4oj74OE1bmGcMmTsYoMjDNGN5dKmoccdjD9dF8bdrLqSHykOse0miH8c3ob0V1XvcF8UKboO75t1c52n6Kh1XYZnh_MUffvw_uvFVXXz6fL64t1N5SUxY1WvFK9b4kWtjTfCa-2J5rpudU2MUkYI4_mq4aRueOO5YKpw5dXUugFHBT9FZ_u8mzT8niCPtg_ZQ9e5MsqU7UoKqaTS-mGScyqNIaqQL--R62GaB8yWCqMplVyQQsk95dOQc4LWblLoXdpZSuzsnl3bg3t2ds8SZku06F4csk91D81_1T-7CvDqALjsXdcmF33IdxxThGk2c2_3HJT_3QZINvsA0UMTUjHbNkN4sJXzexl8F2IoRX_BDvLd1DYXgf0yr9q8abQsGdWC8VumU8-e</recordid><startdate>20100409</startdate><enddate>20100409</enddate><creator>Hwang, Seon Do</creator><creator>Shin, Jin Soo</creator><creator>Ku, Keun Bon</creator><creator>Kim, Hyun Soo</creator><creator>Cho, Sung Whan</creator><creator>Seo, Sang Heui</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20100409</creationdate><title>Protection of pregnant mice, fetuses and neonates from lethality of H5N1 influenza viruses by maternal vaccination</title><author>Hwang, Seon Do ; Shin, Jin Soo ; Ku, Keun Bon ; Kim, Hyun Soo ; Cho, Sung Whan ; Seo, Sang Heui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-b763bf0c4b89c94c88c0838bf8b09669449c37d30bd3dc342689cbf89b8dea143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antibodies, Viral - analysis</topic><topic>Antibodies, Viral - blood</topic><topic>Applied microbiology</topic><topic>Avian flu</topic><topic>Biological and medical sciences</topic><topic>Blood - immunology</topic><topic>Cloning</topic><topic>Cross Protection</topic><topic>Disease control</topic><topic>Female</topic><topic>Fetus</topic><topic>Fetuses</topic><topic>Fundamental and applied biological sciences. 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Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Seon Do</au><au>Shin, Jin Soo</au><au>Ku, Keun Bon</au><au>Kim, Hyun Soo</au><au>Cho, Sung Whan</au><au>Seo, Sang Heui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection of pregnant mice, fetuses and neonates from lethality of H5N1 influenza viruses by maternal vaccination</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2010-04-09</date><risdate>2010</risdate><volume>28</volume><issue>17</issue><spage>2957</spage><epage>2964</epage><pages>2957-2964</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Abstract The highly pathogenic H5N1 influenza viruses are one of candidates for the next pandemic. Information on protective immunity for pregnant animals by vaccination against the H5N1 influenza virus is limited. Here, we show that the immunization of pregnant mice with inactivated H5N1 influenza vaccine protects them, their fetuses, and their infant mice from H5N1 influenza viruses. Pregnant mice immunized with two doses of H5N1 influenza vaccine were protected from homologous infections of H5N1 influenza viruses with no viruses detected in fetuses, and that they were protected upto 30% from heterologous infections of H5N1 influenza viruses with viruses detected in fetuses. The infant mice born to mothers immunized with H5N1 influenza vaccine were fully protected from infections of H5N1 influenza viruses for upto 4 weeks of age. The protection of infant mice was closely related to the presence of IgG2a antibody in lung, heart, and rectum tissues. Our results suggest that maternal vaccination may be critical for protecting pregnant animals, their fetuses, and their infant mice from lethal infections of H5N1 influenza viruses.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20188684</pmid><doi>10.1016/j.vaccine.2010.02.016</doi><tpages>8</tpages></addata></record> |
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| subjects | Allergy and Immunology Animals Animals, Newborn Antibodies, Viral - analysis Antibodies, Viral - blood Applied microbiology Avian flu Biological and medical sciences Blood - immunology Cloning Cross Protection Disease control Female Fetus Fetuses Fundamental and applied biological sciences. Psychology H5N1 Immunization Immunization, Secondary - methods Immunoglobulin G - analysis Immunoglobulin G - blood Infants Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - immunology Influenza virus Lung - immunology Mice Mice, Inbred BALB C Microbiology Miscellaneous Mortality Myocardium - immunology Neonates Orthomyxoviridae Infections - prevention & control Pandemics Plasmids Pregnancy Rectum - immunology Studies Survival Analysis Time Factors Vaccination - methods Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Inactivated - immunology Virology Viruses Womens health |
| title | Protection of pregnant mice, fetuses and neonates from lethality of H5N1 influenza viruses by maternal vaccination |
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