Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation

The class III receptor tyrosine kinase FMS-like tyrosine kinase 3 (FLT3) regulates normal hematopoiesis and immunological functions. Nonetheless, constitutively active mutant FLT3 (FLT3-ITD) causally contributes to transformation and is associated with poor prognosis of acute myeloid leukemia (AML)...

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Veröffentlicht in:	Leukemia 2010-08, Vol.24 (8), p.1412-1421
Hauptverfasser:	Buchwald, M, Pietschmann, K, Müller, J P, Böhmer, F D, Heinzel, T, Krämer, O H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/474/2085 631/92/555 692/699/67/1990/283/1897 Acute myeloid leukemia Anticancer properties Biochemistry Biological and medical sciences Biophysics Blotting, Western Cancer Research Cell Line Cell Separation Cell survival Critical Care Medicine Degradation Deregulation Drug development Drugs Enzymes Flow Cytometry Flt3 protein fms-Like Tyrosine Kinase 3 - genetics fms-Like Tyrosine Kinase 3 - metabolism Gene expression Hematologic and hematopoietic diseases Hematology Hematopoiesis Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Humans Hydrolysis Immunology Immunoprecipitation Intensive Internal Medicine Kinases Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical prognosis Medical sciences Medicine Medicine & Public Health Mutation Myelodysplastic syndromes Oncology original-article Pathogenesis Phosphorylation Physiological aspects Physiological effects Proteasome Endopeptidase Complex - metabolism Proteasomes Protein kinases Protein-tyrosine kinase receptors Proteomes Stability Transcriptomes Tyrosine Tyrosine - metabolism Ubiquitin Ubiquitin-conjugating enzyme Ubiquitin-Conjugating Enzymes - metabolism Ubiquitin-protein ligase
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