Lack of P-glycoprotein induction by rifampicin and phenobarbital in human lymphocytes

The efficacy of drugs acting within lymphocytes depends on their intracellular concentrations, which could be modulated by membrane efflux transporters including P-glycoprotein (P-gp), encoded by the MDR1 gene. In particular, P-gp induction may compromise the efficacy of its substrates. Rifampicin a...

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Veröffentlicht in:	International journal of pharmaceutics 2010-08, Vol.395 (1), p.98-103
Hauptverfasser:	Manceau, S., Giraud, C., Declèves, X., Batteux, F., Chouzenoux, S., Tang, R., Dauchy, S., Scherrmann, J.M., Weill, B., Morini, J.P., Perrot, J.Y., Tréluyer, J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences CAR Drug Interactions Flow Cytometry General pharmacology HL-60 Cells Humans Lymphocyte Lymphocytes - drug effects Lymphocytes - metabolism Medical sciences P-glycoprotein Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phenobarbital Phenobarbital - metabolism Phenobarbital - pharmacology PXR Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Steroid - metabolism Rifampicin Rifampin - metabolism Rifampin - pharmacology RNA, Messenger - metabolism Time Factors Transfection Up-Regulation
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