Salt is necessary for nucleosomal DNA fragmentation induced by caspase

For nucleosomal DNA fragmentation, one of the hallmarks of apoptosis, activated caspase, an apoptosis specific cysteine protease, is required to cleave ICAD/DFF45 that releases its complexed DNase, CAD/DFF40. The protein complex is located predominantly in the nuclei. Inconsistently, caspase alone c...

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Veröffentlicht in:	Biotechnology letters 2005-12, Vol.27 (23-24), p.1935-1942
Hauptverfasser:	KIM, Bo-Eun, LEE, Yun-Hee, SEONG, Changhyun, SONG YUB SHIN, JUNG SUP LEE, BYUNG YUN CHO, PARK, Il-Seon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins Aurintricarboxylic Acid - pharmacology Biological and medical sciences Biotechnology Caspase 3 Caspase Inhibitors Caspases - genetics Caspases - metabolism Cell Nucleus - drug effects Cell Nucleus - genetics Cell Nucleus - metabolism Chromatin - drug effects Chromatin - metabolism Chromatography, Gel Computer aided design Cysteine Cysteine Proteinase Inhibitors - pharmacology Deoxyribonucleases - metabolism Deoxyribonucleic acid DNA DNA Fragmentation - drug effects Fragmentation Fundamental and applied biological sciences. Psychology Humans Jurkat Cells Mutation - genetics Nucleosomes - drug effects Nucleosomes - genetics Nucleosomes - metabolism Oligopeptides - pharmacology Poly-ADP-Ribose Binding Proteins Potassium Chloride - pharmacology Protease Proteins Proteins - genetics Proteins - metabolism Rats Salts - pharmacology Sodium chloride Sodium Chloride - pharmacology
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