Isolation and purification of macrocyclic components from Penicillium fermentation broth by high-speed counter-current chromatography

In this paper, high-speed counter-current chromatography (HSCCC), assisted with ESI-MS, was first successfully applied to the preparative separation of three macrolide antibiotics, brefeldin A (12.6 mg, 99.0%), 7′-O-formylbrefeldin A (6.5 mg, 95.0%) and 7′-O-acetylbrefeldin A (5.0 mg, 92.3%) from th...

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Veröffentlicht in:	Journal of separation science 2010-02, Vol.33 (2), p.277-284
Hauptverfasser:	Gao, Xiang, Zhuang, Rongqiang, Guo, Jiannan, Bao, Jian, Fang, Meijuan, Liu, Yan, Xu, Pengxiang, Zhao, Yufen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemistry Brefeldin A Brefeldin A - analogs & derivatives Brefeldin A - chemistry Brefeldin A - isolation & purification Brefeldin A - metabolism Chromatography Chromatography, High Pressure Liquid Countercurrent Distribution - methods Crystallography, X-Ray Culture Media, Conditioned - chemistry ESI-MS Ethyl acetate Fermentation High speed High-speed counter-current chromatography Macrocyclic compounds Macrocyclic Compounds - chemistry Macrocyclic Compounds - isolation & purification Macrocyclic Compounds - metabolism Macrolide antibiotics Magnetic Resonance Spectroscopy Microorganisms Molecular Structure Penicillium Penicillium - metabolism Preparative chromatography Purity Separation Solvents Solvents - chemistry Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Ultraviolet
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