The influence of osteolytic substances on the production of osseous metastases from walker 256 sarcoma in rats
Reports in the early 1960's suggested the possible relationship between the humoral agents producing hypercalcemia in metastatic malignancy and the appearance of osseous metastases. Hartmann and Sherlock indicated that the use of corticosteroids possibly might alter the ease with which metastas...
Gespeichert in:
| Veröffentlicht in: | Journal of surgical oncology 1974, Vol.6 (2), p.117-121 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 121 |
|---|---|
| container_issue | 2 |
| container_start_page | 117 |
| container_title | Journal of surgical oncology |
| container_volume | 6 |
| creator | Graham III, William P. Tragus, Eugene T. Blakemore, William S. |
| description | Reports in the early 1960's suggested the possible relationship between the humoral agents producing hypercalcemia in metastatic malignancy and the appearance of osseous metastases. Hartmann and Sherlock indicated that the use of corticosteroids possibly might alter the ease with which metastases to the gastrointestinal mucosa occur in breast carcinoma. The present study was an attempt to verify the previous observations of Pentimalli (1960) that hypercalcemia could produce bony metastases in rats.
Using saline controls, ergosterol, methylprcdnisolone, and parathyroid hormone, no bony metastases could be demonstrated in rats implanted with Walker 256 sarcoma. It appears that these osteolytic substances at least within this model do not facilitate the appearance of metastases to bone. |
| doi_str_mv | 10.1002/jso.2930060205 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754561305</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>754561305</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3655-e780fd7ac8f3af32178250a7694f03c752bbe163caab52e714a73ca437ffcfd3</originalsourceid><addsrcrecordid>eNqFkc1PxCAQxYnR6Ppx9WbCzVPXKRQoR2P8Wjea6EYTL4SyEKttUWij-9-L7kbjyRMZ5vfeDA-E9nMY5wDk6Dn6MZEUgAMBtoZGOUieSZDlOholgGSFkLCFtmN8BgApebGJNouSkFLyEepmTxbXnWsG2xmLvcM-9tY3i742OA5V7HW6j9h3uE_ka_DzwfR1Kr_RaP0QcWt7ncCYOBd8i99182IDJozjqIPxrU4jcNB93EUbTjfR7q3OHTQ7O52dXGTTm_PLk-NpZihnLLOiBDcX2pSOakdJLkrCQAsuCwfUCEaqyuacGq0rRqzICy1SUVDhnHFzuoMOl7Zp37fBxl61dTS2aXT3tbASrGA8p8ASOV6SJqTXBOvUa6hbHRYqB_UVsEoBq9-Ak-BgZT1UrZ3_4KtEU18u--91Yxf_uKnJ3c0f72yprdMffPxodXhRXFDB1MP1ubrgk_vbh8crdUY_AarsmFw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>754561305</pqid></control><display><type>article</type><title>The influence of osteolytic substances on the production of osseous metastases from walker 256 sarcoma in rats</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Graham III, William P. ; Tragus, Eugene T. ; Blakemore, William S.</creator><creatorcontrib>Graham III, William P. ; Tragus, Eugene T. ; Blakemore, William S.</creatorcontrib><description>Reports in the early 1960's suggested the possible relationship between the humoral agents producing hypercalcemia in metastatic malignancy and the appearance of osseous metastases. Hartmann and Sherlock indicated that the use of corticosteroids possibly might alter the ease with which metastases to the gastrointestinal mucosa occur in breast carcinoma. The present study was an attempt to verify the previous observations of Pentimalli (1960) that hypercalcemia could produce bony metastases in rats.
Using saline controls, ergosterol, methylprcdnisolone, and parathyroid hormone, no bony metastases could be demonstrated in rats implanted with Walker 256 sarcoma. It appears that these osteolytic substances at least within this model do not facilitate the appearance of metastases to bone.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.2930060205</identifier><identifier>PMID: 4822896</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Bone and Bones - drug effects ; Bone Neoplasms - pathology ; Bone Resorption - chemically induced ; Carcinoma 256, Walker - pathology ; Ergosterol - pharmacology ; Hypercalcemia - chemically induced ; Hypercalcemia - complications ; Injections, Intraperitoneal ; Injections, Subcutaneous ; Liver Neoplasms - pathology ; Lung Neoplasms - pathology ; Male ; Methylprednisolone - pharmacology ; Neoplasm Metastasis ; Parathyroid Hormone - pharmacology ; Rats</subject><ispartof>Journal of surgical oncology, 1974, Vol.6 (2), p.117-121</ispartof><rights>Copyright © 1974 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3655-e780fd7ac8f3af32178250a7694f03c752bbe163caab52e714a73ca437ffcfd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.2930060205$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.2930060205$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4822896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graham III, William P.</creatorcontrib><creatorcontrib>Tragus, Eugene T.</creatorcontrib><creatorcontrib>Blakemore, William S.</creatorcontrib><title>The influence of osteolytic substances on the production of osseous metastases from walker 256 sarcoma in rats</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Reports in the early 1960's suggested the possible relationship between the humoral agents producing hypercalcemia in metastatic malignancy and the appearance of osseous metastases. Hartmann and Sherlock indicated that the use of corticosteroids possibly might alter the ease with which metastases to the gastrointestinal mucosa occur in breast carcinoma. The present study was an attempt to verify the previous observations of Pentimalli (1960) that hypercalcemia could produce bony metastases in rats.
Using saline controls, ergosterol, methylprcdnisolone, and parathyroid hormone, no bony metastases could be demonstrated in rats implanted with Walker 256 sarcoma. It appears that these osteolytic substances at least within this model do not facilitate the appearance of metastases to bone.</description><subject>Animals</subject><subject>Bone and Bones - drug effects</subject><subject>Bone Neoplasms - pathology</subject><subject>Bone Resorption - chemically induced</subject><subject>Carcinoma 256, Walker - pathology</subject><subject>Ergosterol - pharmacology</subject><subject>Hypercalcemia - chemically induced</subject><subject>Hypercalcemia - complications</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Subcutaneous</subject><subject>Liver Neoplasms - pathology</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Methylprednisolone - pharmacology</subject><subject>Neoplasm Metastasis</subject><subject>Parathyroid Hormone - pharmacology</subject><subject>Rats</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1PxCAQxYnR6Ppx9WbCzVPXKRQoR2P8Wjea6EYTL4SyEKttUWij-9-L7kbjyRMZ5vfeDA-E9nMY5wDk6Dn6MZEUgAMBtoZGOUieSZDlOholgGSFkLCFtmN8BgApebGJNouSkFLyEepmTxbXnWsG2xmLvcM-9tY3i742OA5V7HW6j9h3uE_ka_DzwfR1Kr_RaP0QcWt7ncCYOBd8i99182IDJozjqIPxrU4jcNB93EUbTjfR7q3OHTQ7O52dXGTTm_PLk-NpZihnLLOiBDcX2pSOakdJLkrCQAsuCwfUCEaqyuacGq0rRqzICy1SUVDhnHFzuoMOl7Zp37fBxl61dTS2aXT3tbASrGA8p8ASOV6SJqTXBOvUa6hbHRYqB_UVsEoBq9-Ak-BgZT1UrZ3_4KtEU18u--91Yxf_uKnJ3c0f72yprdMffPxodXhRXFDB1MP1ubrgk_vbh8crdUY_AarsmFw</recordid><startdate>1974</startdate><enddate>1974</enddate><creator>Graham III, William P.</creator><creator>Tragus, Eugene T.</creator><creator>Blakemore, William S.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope></search><sort><creationdate>1974</creationdate><title>The influence of osteolytic substances on the production of osseous metastases from walker 256 sarcoma in rats</title><author>Graham III, William P. ; Tragus, Eugene T. ; Blakemore, William S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3655-e780fd7ac8f3af32178250a7694f03c752bbe163caab52e714a73ca437ffcfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Animals</topic><topic>Bone and Bones - drug effects</topic><topic>Bone Neoplasms - pathology</topic><topic>Bone Resorption - chemically induced</topic><topic>Carcinoma 256, Walker - pathology</topic><topic>Ergosterol - pharmacology</topic><topic>Hypercalcemia - chemically induced</topic><topic>Hypercalcemia - complications</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Subcutaneous</topic><topic>Liver Neoplasms - pathology</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Methylprednisolone - pharmacology</topic><topic>Neoplasm Metastasis</topic><topic>Parathyroid Hormone - pharmacology</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graham III, William P.</creatorcontrib><creatorcontrib>Tragus, Eugene T.</creatorcontrib><creatorcontrib>Blakemore, William S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graham III, William P.</au><au>Tragus, Eugene T.</au><au>Blakemore, William S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of osteolytic substances on the production of osseous metastases from walker 256 sarcoma in rats</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>1974</date><risdate>1974</risdate><volume>6</volume><issue>2</issue><spage>117</spage><epage>121</epage><pages>117-121</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Reports in the early 1960's suggested the possible relationship between the humoral agents producing hypercalcemia in metastatic malignancy and the appearance of osseous metastases. Hartmann and Sherlock indicated that the use of corticosteroids possibly might alter the ease with which metastases to the gastrointestinal mucosa occur in breast carcinoma. The present study was an attempt to verify the previous observations of Pentimalli (1960) that hypercalcemia could produce bony metastases in rats.
Using saline controls, ergosterol, methylprcdnisolone, and parathyroid hormone, no bony metastases could be demonstrated in rats implanted with Walker 256 sarcoma. It appears that these osteolytic substances at least within this model do not facilitate the appearance of metastases to bone.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>4822896</pmid><doi>10.1002/jso.2930060205</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-4790 |
| ispartof | Journal of surgical oncology, 1974, Vol.6 (2), p.117-121 |
| issn | 0022-4790 1096-9098 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_754561305 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Bone and Bones - drug effects Bone Neoplasms - pathology Bone Resorption - chemically induced Carcinoma 256, Walker - pathology Ergosterol - pharmacology Hypercalcemia - chemically induced Hypercalcemia - complications Injections, Intraperitoneal Injections, Subcutaneous Liver Neoplasms - pathology Lung Neoplasms - pathology Male Methylprednisolone - pharmacology Neoplasm Metastasis Parathyroid Hormone - pharmacology Rats |
| title | The influence of osteolytic substances on the production of osseous metastases from walker 256 sarcoma in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T15%3A56%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20influence%20of%20osteolytic%20substances%20on%20the%20production%20of%20osseous%20metastases%20from%20walker%20256%20sarcoma%20in%20rats&rft.jtitle=Journal%20of%20surgical%20oncology&rft.au=Graham%20III,%20William%20P.&rft.date=1974&rft.volume=6&rft.issue=2&rft.spage=117&rft.epage=121&rft.pages=117-121&rft.issn=0022-4790&rft.eissn=1096-9098&rft_id=info:doi/10.1002/jso.2930060205&rft_dat=%3Cproquest_cross%3E754561305%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=754561305&rft_id=info:pmid/4822896&rfr_iscdi=true |