Release of Interleukin-1 Receptor Antagonist by Combining a Leukocyte Adsorption Carrier With Ulinastatin

Both granulocyte/monocyte adsorptive apheresis (GMA) and ulinastatin, a serine protease inhibitor, are reported to be effective in patients with ulcerative colitis; however, combination therapy with GMA and ulinastatin has not been attempted. Investigating the effect of ulinastatin on GMA is require...

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Veröffentlicht in:	Therapeutic apheresis and dialysis 2010-08, Vol.14 (4), p.386-391
Hauptverfasser:	Nishise, Shoichi, Takeda, Yuji, Fujishima, Shoichiro, Orii, Tomohiko, Sato, Takeshi, Sasaki, Yu, Nishise, Yuko, Takeda, Hiroaki, Kawata, Sumio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Blood Component Removal - methods Cellulose - analogs & derivatives Cellulose - chemistry Colitis, Ulcerative - therapy Dose-Response Relationship, Drug Flavonoids - pharmacology Gabexate - pharmacology Glycoproteins - administration & dosage Glycoproteins - pharmacology Granulocytes Granulocytes - metabolism Humans In Vitro Techniques Interleukin-1 receptor antagonist Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Monocytes - metabolism Receptors, Interleukin-1 - antagonists & inhibitors Trypsin Inhibitors - administration & dosage Trypsin Inhibitors - pharmacology Ulcerative colitis Ulinastatin
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