An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic?
Please cite this paper as: An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic? Experimental Dermatology 2010; 19: e347–e349. : Natural killer (NK) cells have become a recent focus of interest in alopecia areata (AA) research. To further invest...
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| Veröffentlicht in: | Experimental dermatology 2010-08, Vol.19 (8), p.e347-e349 |
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| creator | Kaufman, Gil D'Ovidio, Roberto Kaldawy, Anis Assy, Bedia Ullmann, Yehuda Etzioni, Amos Paus, Ralf Gilhar, Amos |
| description | Please cite this paper as: An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic? Experimental Dermatology 2010; 19: e347–e349.
: Natural killer (NK) cells have become a recent focus of interest in alopecia areata (AA) research. To further investigate their role in an established mouse model of AA, lesional skin from older C3H/HeJ mice with AA was grafted to young C3H/HeJ female mice, and NK cells were depleted by continuous administration of rabbit anti‐asialo GM1. As expected, this significantly reduced the number of pure NK cells in murine skin, as assessed by NKp46 quantitative immunohistochemistry. Quite unexpectedly, however, the onset of hair loss in C3H/HeJ mice was accelerated, rather than retarded. NK cell depletion was accompanied by a significant increase in the number of perifollicular CD49b+T cells in the alopecic skin of anti‐asialo GM1‐treated mice. These findings underscore the need to carefully distinguish in future AA research between pure NK cells and defined subsets of CD49b+ lymphocytes, as they may exert diametrically opposed functions in hair follicle immunology and immunopathology. |
| doi_str_mv | 10.1111/j.1600-0625.2010.01106.x |
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: Natural killer (NK) cells have become a recent focus of interest in alopecia areata (AA) research. To further investigate their role in an established mouse model of AA, lesional skin from older C3H/HeJ mice with AA was grafted to young C3H/HeJ female mice, and NK cells were depleted by continuous administration of rabbit anti‐asialo GM1. As expected, this significantly reduced the number of pure NK cells in murine skin, as assessed by NKp46 quantitative immunohistochemistry. Quite unexpectedly, however, the onset of hair loss in C3H/HeJ mice was accelerated, rather than retarded. NK cell depletion was accompanied by a significant increase in the number of perifollicular CD49b+T cells in the alopecic skin of anti‐asialo GM1‐treated mice. These findings underscore the need to carefully distinguish in future AA research between pure NK cells and defined subsets of CD49b+ lymphocytes, as they may exert diametrically opposed functions in hair follicle immunology and immunopathology.</description><identifier>ISSN: 0906-6705</identifier><identifier>EISSN: 1600-0625</identifier><identifier>DOI: 10.1111/j.1600-0625.2010.01106.x</identifier><identifier>PMID: 20653774</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>alopecia Areata ; Alopecia Areata - pathology ; Alopecia Areata - physiopathology ; Animals ; Antibodies, Anti-Idiotypic - administration & dosage ; Antibodies, Anti-Idiotypic - pharmacology ; autoimmunity ; CD49b+ cells ; Disease Models, Animal ; Female ; Injections ; Integrin alpha2 - metabolism ; Killer Cells, Natural - drug effects ; Killer Cells, Natural - pathology ; Killer Cells, Natural - physiology ; Mice ; Mice, Inbred C3H ; NK cells ; T-Lymphocytes - immunology ; T-Lymphocytes - pathology ; T-Lymphocytes - physiology</subject><ispartof>Experimental dermatology, 2010-08, Vol.19 (8), p.e347-e349</ispartof><rights>2010 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4886-48bfcfbdcbb913778614e7ef3085b5d6533656777bbb1897f9690a0d51c919df3</citedby><cites>FETCH-LOGICAL-c4886-48bfcfbdcbb913778614e7ef3085b5d6533656777bbb1897f9690a0d51c919df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0625.2010.01106.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0625.2010.01106.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20653774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaufman, Gil</creatorcontrib><creatorcontrib>D'Ovidio, Roberto</creatorcontrib><creatorcontrib>Kaldawy, Anis</creatorcontrib><creatorcontrib>Assy, Bedia</creatorcontrib><creatorcontrib>Ullmann, Yehuda</creatorcontrib><creatorcontrib>Etzioni, Amos</creatorcontrib><creatorcontrib>Paus, Ralf</creatorcontrib><creatorcontrib>Gilhar, Amos</creatorcontrib><title>An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic?</title><title>Experimental dermatology</title><addtitle>Exp Dermatol</addtitle><description>Please cite this paper as: An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic? Experimental Dermatology 2010; 19: e347–e349.
: Natural killer (NK) cells have become a recent focus of interest in alopecia areata (AA) research. To further investigate their role in an established mouse model of AA, lesional skin from older C3H/HeJ mice with AA was grafted to young C3H/HeJ female mice, and NK cells were depleted by continuous administration of rabbit anti‐asialo GM1. As expected, this significantly reduced the number of pure NK cells in murine skin, as assessed by NKp46 quantitative immunohistochemistry. Quite unexpectedly, however, the onset of hair loss in C3H/HeJ mice was accelerated, rather than retarded. NK cell depletion was accompanied by a significant increase in the number of perifollicular CD49b+T cells in the alopecic skin of anti‐asialo GM1‐treated mice. These findings underscore the need to carefully distinguish in future AA research between pure NK cells and defined subsets of CD49b+ lymphocytes, as they may exert diametrically opposed functions in hair follicle immunology and immunopathology.</description><subject>alopecia Areata</subject><subject>Alopecia Areata - pathology</subject><subject>Alopecia Areata - physiopathology</subject><subject>Animals</subject><subject>Antibodies, Anti-Idiotypic - administration & dosage</subject><subject>Antibodies, Anti-Idiotypic - pharmacology</subject><subject>autoimmunity</subject><subject>CD49b+ cells</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Injections</subject><subject>Integrin alpha2 - metabolism</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Killer Cells, Natural - pathology</subject><subject>Killer Cells, Natural - physiology</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>NK cells</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - pathology</subject><subject>T-Lymphocytes - physiology</subject><issn>0906-6705</issn><issn>1600-0625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUctO4zAUtRAIOsAvjLybBUq5buJHRkIIlad4bcpDs7Hs5AZc0qQTp1D-HoeWbsEbW-eec310DiGUQZ-Fsz_uMwEQgRjw_gACCoyB6M_XSG81WCc9SEFEQgLfIr-8HwMwGUu-SbYGIHgsZdIjL0cVnVU4n2LWYk7bN-db6ipqyjpAzlDToGkNnZr2uX7CCr3zfzuQ3lzSDMvS02lTt0HtXpGaKqfD4yS1e3T0NV0KXXa4QzYKU3rcXd7b5O70ZDQ8j65uzy6GR1dRliglokTZIitsnlmbsuBSCZagxCIGxS3Pg_NYcCGltNYylcoiFSkYyDnLUpbmRbxN_iz2Bmf_Z-hbPXG-c2MqrGdeS55wrpTk3zPjJKQb0gpMtWBmTe19g4WeNm5imnfNQHed6LHuotdd9LrrRH92oudB-nv5ycxOMF8Jv0oIhIMF4c2V-P7jxfrk8bh7BX200IfucL7Sm-ZFi65w_XBzpkeP18k9u_ynr-MPAkiobQ</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Kaufman, Gil</creator><creator>D'Ovidio, Roberto</creator><creator>Kaldawy, Anis</creator><creator>Assy, Bedia</creator><creator>Ullmann, Yehuda</creator><creator>Etzioni, Amos</creator><creator>Paus, Ralf</creator><creator>Gilhar, Amos</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201008</creationdate><title>An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic?</title><author>Kaufman, Gil ; D'Ovidio, Roberto ; Kaldawy, Anis ; Assy, Bedia ; Ullmann, Yehuda ; Etzioni, Amos ; Paus, Ralf ; Gilhar, Amos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4886-48bfcfbdcbb913778614e7ef3085b5d6533656777bbb1897f9690a0d51c919df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>alopecia Areata</topic><topic>Alopecia Areata - pathology</topic><topic>Alopecia Areata - physiopathology</topic><topic>Animals</topic><topic>Antibodies, Anti-Idiotypic - administration & dosage</topic><topic>Antibodies, Anti-Idiotypic - pharmacology</topic><topic>autoimmunity</topic><topic>CD49b+ cells</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Injections</topic><topic>Integrin alpha2 - metabolism</topic><topic>Killer Cells, Natural - drug effects</topic><topic>Killer Cells, Natural - pathology</topic><topic>Killer Cells, Natural - physiology</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>NK cells</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - pathology</topic><topic>T-Lymphocytes - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaufman, Gil</creatorcontrib><creatorcontrib>D'Ovidio, Roberto</creatorcontrib><creatorcontrib>Kaldawy, Anis</creatorcontrib><creatorcontrib>Assy, Bedia</creatorcontrib><creatorcontrib>Ullmann, Yehuda</creatorcontrib><creatorcontrib>Etzioni, Amos</creatorcontrib><creatorcontrib>Paus, Ralf</creatorcontrib><creatorcontrib>Gilhar, Amos</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaufman, Gil</au><au>D'Ovidio, Roberto</au><au>Kaldawy, Anis</au><au>Assy, Bedia</au><au>Ullmann, Yehuda</au><au>Etzioni, Amos</au><au>Paus, Ralf</au><au>Gilhar, Amos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic?</atitle><jtitle>Experimental dermatology</jtitle><addtitle>Exp Dermatol</addtitle><date>2010-08</date><risdate>2010</risdate><volume>19</volume><issue>8</issue><spage>e347</spage><epage>e349</epage><pages>e347-e349</pages><issn>0906-6705</issn><eissn>1600-0625</eissn><abstract>Please cite this paper as: An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic? Experimental Dermatology 2010; 19: e347–e349.
: Natural killer (NK) cells have become a recent focus of interest in alopecia areata (AA) research. To further investigate their role in an established mouse model of AA, lesional skin from older C3H/HeJ mice with AA was grafted to young C3H/HeJ female mice, and NK cells were depleted by continuous administration of rabbit anti‐asialo GM1. As expected, this significantly reduced the number of pure NK cells in murine skin, as assessed by NKp46 quantitative immunohistochemistry. Quite unexpectedly, however, the onset of hair loss in C3H/HeJ mice was accelerated, rather than retarded. NK cell depletion was accompanied by a significant increase in the number of perifollicular CD49b+T cells in the alopecic skin of anti‐asialo GM1‐treated mice. These findings underscore the need to carefully distinguish in future AA research between pure NK cells and defined subsets of CD49b+ lymphocytes, as they may exert diametrically opposed functions in hair follicle immunology and immunopathology.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20653774</pmid><doi>10.1111/j.1600-0625.2010.01106.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | alopecia Areata Alopecia Areata - pathology Alopecia Areata - physiopathology Animals Antibodies, Anti-Idiotypic - administration & dosage Antibodies, Anti-Idiotypic - pharmacology autoimmunity CD49b+ cells Disease Models, Animal Female Injections Integrin alpha2 - metabolism Killer Cells, Natural - drug effects Killer Cells, Natural - pathology Killer Cells, Natural - physiology Mice Mice, Inbred C3H NK cells T-Lymphocytes - immunology T-Lymphocytes - pathology T-Lymphocytes - physiology |
| title | An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic? |
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