Pyrazinamide resistance in multidrug-resistant Mycobacterium tuberculosis isolates in Japan

Thirty-six multidrug-resistant (MDR) Mycobacterium tuberculosis isolates collected in Japan were examined for pyrazinamide susceptibility and pyrazinamidase activity, and analysed by pncA sequencing and a hybridization-based line probe assay (LiPA), which was used to detect pncA mutations for the ra...

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Veröffentlicht in:	Clinical microbiology and infection 2010-08, Vol.16 (8), p.1164-1168
Hauptverfasser:	Ando, H., Mitarai, S., Kondo, Y., Suetake, T., Sekiguchi, J.-I., Kato, S., Mori, T., Kirikae, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - genetics Amidohydrolases - metabolism Antitubercular Agents - pharmacology DNA sequencing DNA, Bacterial - chemistry DNA, Bacterial - genetics Drug resistance Drug Resistance, Multiple, Bacterial Humans Japan Line probe assay multidrug resistance Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - isolation & purification Nucleic Acid Hybridization pncA Point Mutation Probes pyrazinamide Pyrazinamide - pharmacology Sequence Analysis, DNA Sequence Deletion Tuberculosis
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