Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice

Epidemiology supports the important role of nutrition in prostate cancer (PCa) prevention. Pomegranate juice (PJ) exerts protective effects against PCa, mainly attributed to PJ ellagitannins (ETs). Our aim was to assess whether ETs or their metabolites ellagic acid and urolithins reach the human pro...

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Veröffentlicht in:	Molecular nutrition & food research 2010-03, Vol.54 (3), p.311-322
Hauptverfasser:	GONZALEZ-SARNAS, Antonio, GIMENEZ-BASTIDA, Juan A, MARTINEZ-DIAZ, Francisco, TOMAS-BARBERAN, Francisco A, ESPIN, Juan Carlos, GARCIA-CONESA, María T, GOMEZ-SANCHEZ, María B, GARCIA-TALAVERA, Noelia V, GIL-IZQUIERDO, Angel, SANCHEZ-ALVAREZ, Carmen, FONTANA-COMPIANO, Luis O, MORGA-EGEA, Juan P, PASTOR-QUIRANTE, Francisco A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Beverages - analysis Bioavailability Biological and medical sciences Biomarkers, Tumor - metabolism Cancer Coumarins - administration & dosage Coumarins - chemistry Coumarins - metabolism Coumarins - urine Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Ellagic Acid - chemistry Ellagic Acid - metabolism Ellagic Acid - urine Ellagitannins Feeding. Feeding behavior Food industries Fruit - chemistry Fruit and vegetable industries Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Neoplastic Glucuronides - administration & dosage Glucuronides - chemistry Glucuronides - metabolism Glucuronides - urine Humans Hydrolyzable Tannins - administration & dosage Hydrolyzable Tannins - chemistry Hydrolyzable Tannins - metabolism Intestines - microbiology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Juglans Juglans - chemistry Male Middle Aged Nuclear Proteins - genetics Nuclear Proteins - metabolism Plant Extracts - administration & dosage Plant Extracts - chemistry Polyphenol Prostate - metabolism Prostatic Hyperplasia - metabolism Prostatic Hyperplasia - surgery Prostatic Hyperplasia - urine Prostatic Neoplasms - metabolism Prostatic Neoplasms - prevention & control Prostatic Neoplasms - surgery Prostatic Neoplasms - urine Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Punicaceae - chemistry Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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