Intravenous nicotine self-administration in rats: effects of mecamylamine, hexamethonium and naloxone

The rate and pattern of lever pressing were studied in 18 rats during 24-h sessions in which responding resulted in intravenous infusions of nicotine. There were four indications of the positive reinforcing effect of nicotine: (1) a greater number of lever presses when nicotine was response-continge...

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Veröffentlicht in:	Psychopharmacology 2006-02, Vol.184 (3-4), p.266-272
Hauptverfasser:	DeNoble, Victor J, Mele, Paul C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Association Learning - drug effects Brain - drug effects Catheters Conditioning, Operant - drug effects Disease Models, Animal Dose-Response Relationship, Drug Drug dosages Food Hexamethonium - pharmacology Humans Infusion pumps Infusions, Intravenous Male Mecamylamine - pharmacology Naloxone - pharmacology Nicotine Nicotine - administration & dosage Nicotinic Antagonists - pharmacology Psychopharmacology Rats Rats, Long-Evans Receptors, Nicotinic - drug effects Receptors, Opioid - drug effects Reinforcement Schedule Schedules
Online-Zugang:	Volltext
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