CSF protein biomarkers for proximal axonal damage improve prognostic accuracy in the acute phase of Guillain-Barré syndrome

Early predictors of prognosis in Guillain‐Barré syndrome (GBS) are needed to identify patients who are likely to make a poor recovery and to guide therapeutic decision‐making in the acute phase. Here we investigate whether axonal protein biomarkers released into the cerebrospinal fluid (CSF) followi...

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Veröffentlicht in:	Muscle & nerve 2009-07, Vol.40 (1), p.42-49
Hauptverfasser:	Petzold, A., Brettschneider, J., Jin, K., Keir, G., Murray, N.M.F., Hirsch, N.P., Itoyama, Y., Reilly, M.M., Takeda, A., Tumani, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Axons - pathology Biological and medical sciences Biomarkers - metabolism cerebrospinal fluid Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Cross-Sectional Studies Disease Progression Female glial fibrillary acidic protein Glial Fibrillary Acidic Protein - cerebrospinal fluid Guillain-Barre Syndrome - cerebrospinal fluid Guillain-Barre Syndrome - physiopathology Guillain-Barre Syndrome - therapy Humans Male Medical sciences Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Multivariate Analysis Nerve Growth Factors - cerebrospinal fluid Nervous system (semeiology, syndromes) Neural Conduction - physiology Neurofilament Proteins - cerebrospinal fluid neurofilaments Neurology Outcome Assessment (Health Care) - methods polyradiculopathy Prospective Studies protein biomarker Reproducibility of Results Retrospective Studies S100 Calcium Binding Protein beta Subunit S100 Proteins - cerebrospinal fluid S100B Severity of Illness Index surrogate marker tau tau Proteins - cerebrospinal fluid
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