Urothelial overexpression of insulin-like growth factor-1 increases susceptibility to p-cresidine-induced bladder carcinogenesis in transgenic mice

To establish a role for insulin‐like growth factor‐1 (IGF‐1) in bladder cancer susceptibility, we tested the effect of p‐cresidine, a potent bladder carcinogen, in transgenic (TG) mice with human IGF‐1 expression in the bladder driven by the bovine keratin 5 promoter (referred to as BK5.IGF‐1 TG mic...

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Veröffentlicht in:	Molecular carcinogenesis 2009-08, Vol.48 (8), p.671-677
Hauptverfasser:	Hursting, Stephen D., Perkins, Susan N., Lavigne, Jackie A., Beltran, Linda, Haines, Diana C., Hill, Heather L., Alvord, W. Gregory, Barrett, J. Carl, DiGiovanni, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - toxicity Animals Carcinoma, Transitional Cell - chemically induced Carcinoma, Transitional Cell - metabolism Carcinoma, Transitional Cell - pathology Cattle Female growth hormone Humans indomethacin Insulin-Like Growth Factor I - metabolism Keratin-5 - genetics Mice Mice, Transgenic Papilloma - chemically induced Papilloma - metabolism Papilloma - pathology Promoter Regions, Genetic transitional cell carcinoma Urinary Bladder - drug effects Urinary Bladder - metabolism Urinary Bladder - pathology Urinary Bladder Neoplasms - chemically induced Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology
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