Prion protein expression and the M129V polymorphism of the PRNP gene in patients with colorectal cancer

The prion protein, PrPC, is known mostly for its involvement in neurodegenerative spongiform encephalopathies. However, a role for this molecule in cancer is becoming increasingly recognized partly because it promotes cell proliferation and inhibits apoptosis. Moreover, the codon 129 polymorphism (M...

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Veröffentlicht in:	Molecular carcinogenesis 2010-07, Vol.49 (7), p.693-699
Hauptverfasser:	Antonacopoulou, Anna G., Palli, Maria, Marousi, Stella, Dimitrakopoulos, Fotinos-Ioannis, Kyriakopoulou, Urania, Tsamandas, Athanasios C., Scopa, Chrisoula D., Papavassiliou, Athanasios G., Kalofonos, Haralabos P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over clinicopathological data Colorectal Neoplasms - genetics Female Gene Expression Regulation, Neoplastic Gene Frequency Genotype genotyping Humans immunohistochemitry Male Middle Aged Polymorphism, Single Nucleotide PrPC Proteins - genetics real time PCR Retrospective Studies RNA, Messenger - genetics
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