A new approach to the treatment of cerebral vasospasm: the angiographic effects of tadalafil on experimental vasospasm

Background The pathogenesis of cerebral vasospasm is likely to be multifactorial. Strong evidence has indicated that decreasing levels of NO after SAH seem to be important. A PDE-V inhibitor, tadalafil, theoretically increases NO levels. Our study investigated the vasodilatory efficacy of tadalafil...

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Veröffentlicht in:	Acta neurochirurgica 2010-03, Vol.152 (3), p.463-469
Hauptverfasser:	Koktekir, Ender, Erdem, Yavuz, Akif Bayar, Mehmet, Gokcek, Cevdet, Karatay, Mete, Kilic, Celal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basilar Artery - diagnostic imaging Basilar Artery - drug effects Basilar Artery - physiopathology Carbolines - pharmacology Carbolines - therapeutic use Cerebral Angiography Cerebral Arteries - diagnostic imaging Cerebral Arteries - drug effects Cerebral Arteries - physiopathology Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Cyclic GMP - agonists Cyclic GMP - metabolism Disease Models, Animal Drug Administration Schedule Experimental Research Interventional Radiology Male Medicine Medicine & Public Health Minimally Invasive Surgery Neurology Neuroradiology Neurosurgery Nitric Oxide - agonists Nitric Oxide - metabolism Phosphodiesterase Inhibitors - pharmacology Phosphodiesterase Inhibitors - therapeutic use Rats Rats, Wistar Subarachnoid Hemorrhage - complications Surgical Orthopedics Tadalafil Time Factors Treatment Outcome Vasodilation - drug effects Vasodilation - physiology Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use Vasospasm, Intracranial - diagnostic imaging Vasospasm, Intracranial - drug therapy Vasospasm, Intracranial - physiopathology
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