A new approach to the treatment of cerebral vasospasm: the angiographic effects of tadalafil on experimental vasospasm
Background The pathogenesis of cerebral vasospasm is likely to be multifactorial. Strong evidence has indicated that decreasing levels of NO after SAH seem to be important. A PDE-V inhibitor, tadalafil, theoretically increases NO levels. Our study investigated the vasodilatory efficacy of tadalafil...
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| Veröffentlicht in: | Acta neurochirurgica 2010-03, Vol.152 (3), p.463-469 |
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| creator | Koktekir, Ender Erdem, Yavuz Akif Bayar, Mehmet Gokcek, Cevdet Karatay, Mete Kilic, Celal |
| description | Background
The pathogenesis of cerebral vasospasm is likely to be multifactorial. Strong evidence has indicated that decreasing levels of NO after SAH seem to be important. A PDE-V inhibitor, tadalafil, theoretically increases NO levels. Our study investigated the vasodilatory efficacy of tadalafil on the cerebral arteries with measurement of basilar artery diameters on angiography.
Methods
We used 42 male Wistar-Albino rats to test our hypothesis. They were assigned randomly into the following seven groups: group 1: control (only saline), group 2: SAH only (killed on day 2), group 3: SAH + tadalafil (killed on day 2), group 4: SAH only (killed on day 4), group 5: SAH + tadalafil (killed on day 4), group 6: saline + tadalafil (killed on day 2) and group 7: saline + tadalafil (killed on day 4). The three different parts of basilar artery diameters were measured angiographically.
Results
There were statistically significant differences between the SAH and SAH groups treated with tadalafil at days 2 and 4. Comparison between control and tadalafil groups showed no significant differences. This result indicated that tadalafil has a vasodilatory effect on vasoconstricted arteries, but no effect on normal basilar arteries.
Conclusion
Our study results showed that tadalafil has a vasodilatory effect on both acute and chronic periods of cerebral vasospasm. We also concluded that cerebral angiography can be used safely for investigation of cerebral vasospasm in animal studies. |
| doi_str_mv | 10.1007/s00701-009-0540-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754555544</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733292237</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-5a76fca0361ce89e9cab30cfca4d924a93428adb1643fff5d81ab33edc97a43d3</originalsourceid><addsrcrecordid>eNqFkclqHDEQhkVIiJfkAXIJIpecOtHWi3wzJnYMhlySs6hRl2ba9LTaksaevL1rPAMOBhMdSkt99Yuqn7FPUnyTQrTfMwUhKyFsJWojqu0bdiysURUF8ZbOgrKNarojdpLzLd1Ua_R7diRtZ2RXN8fs_pxP-MBhnlMEv-Il8rJCXhJCWeNUeAzcY8JFgpHfQ455hrw-e4JgWg5xmWBeDZ5jCOhL3vEFehghDCOPE8ftjGnYSf0r8IG9CzBm_HjYT9mfyx-_L35WN7-uri_ObypvhCpVDW0TPAjdSI-dRethoYWnJ9NbZcBqozroF7IxOoRQ950kQGPvbQtG9_qUfd3rUnt3G8zFrYfscRxhwrjJrq1NTcuY_5NaK6uUbon88oK8jZs0URtOaRp5a5UkSO4hn2LOCYObaQqQ_jop3M48tzfPkXluZ57bUs3ng_Bmscb-ueLgFgFqD2RKTUtMzz-_rvoImvqm1g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>230007921</pqid></control><display><type>article</type><title>A new approach to the treatment of cerebral vasospasm: the angiographic effects of tadalafil on experimental vasospasm</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Koktekir, Ender ; Erdem, Yavuz ; Akif Bayar, Mehmet ; Gokcek, Cevdet ; Karatay, Mete ; Kilic, Celal</creator><creatorcontrib>Koktekir, Ender ; Erdem, Yavuz ; Akif Bayar, Mehmet ; Gokcek, Cevdet ; Karatay, Mete ; Kilic, Celal</creatorcontrib><description>Background
The pathogenesis of cerebral vasospasm is likely to be multifactorial. Strong evidence has indicated that decreasing levels of NO after SAH seem to be important. A PDE-V inhibitor, tadalafil, theoretically increases NO levels. Our study investigated the vasodilatory efficacy of tadalafil on the cerebral arteries with measurement of basilar artery diameters on angiography.
Methods
We used 42 male Wistar-Albino rats to test our hypothesis. They were assigned randomly into the following seven groups: group 1: control (only saline), group 2: SAH only (killed on day 2), group 3: SAH + tadalafil (killed on day 2), group 4: SAH only (killed on day 4), group 5: SAH + tadalafil (killed on day 4), group 6: saline + tadalafil (killed on day 2) and group 7: saline + tadalafil (killed on day 4). The three different parts of basilar artery diameters were measured angiographically.
Results
There were statistically significant differences between the SAH and SAH groups treated with tadalafil at days 2 and 4. Comparison between control and tadalafil groups showed no significant differences. This result indicated that tadalafil has a vasodilatory effect on vasoconstricted arteries, but no effect on normal basilar arteries.
Conclusion
Our study results showed that tadalafil has a vasodilatory effect on both acute and chronic periods of cerebral vasospasm. We also concluded that cerebral angiography can be used safely for investigation of cerebral vasospasm in animal studies.</description><identifier>ISSN: 0001-6268</identifier><identifier>EISSN: 0942-0940</identifier><identifier>DOI: 10.1007/s00701-009-0540-x</identifier><identifier>PMID: 19841856</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Animals ; Basilar Artery - diagnostic imaging ; Basilar Artery - drug effects ; Basilar Artery - physiopathology ; Carbolines - pharmacology ; Carbolines - therapeutic use ; Cerebral Angiography ; Cerebral Arteries - diagnostic imaging ; Cerebral Arteries - drug effects ; Cerebral Arteries - physiopathology ; Cerebrovascular Circulation - drug effects ; Cerebrovascular Circulation - physiology ; Cyclic GMP - agonists ; Cyclic GMP - metabolism ; Disease Models, Animal ; Drug Administration Schedule ; Experimental Research ; Interventional Radiology ; Male ; Medicine ; Medicine & Public Health ; Minimally Invasive Surgery ; Neurology ; Neuroradiology ; Neurosurgery ; Nitric Oxide - agonists ; Nitric Oxide - metabolism ; Phosphodiesterase Inhibitors - pharmacology ; Phosphodiesterase Inhibitors - therapeutic use ; Rats ; Rats, Wistar ; Subarachnoid Hemorrhage - complications ; Surgical Orthopedics ; Tadalafil ; Time Factors ; Treatment Outcome ; Vasodilation - drug effects ; Vasodilation - physiology ; Vasodilator Agents - pharmacology ; Vasodilator Agents - therapeutic use ; Vasospasm, Intracranial - diagnostic imaging ; Vasospasm, Intracranial - drug therapy ; Vasospasm, Intracranial - physiopathology</subject><ispartof>Acta neurochirurgica, 2010-03, Vol.152 (3), p.463-469</ispartof><rights>Springer-Verlag 2009</rights><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-5a76fca0361ce89e9cab30cfca4d924a93428adb1643fff5d81ab33edc97a43d3</citedby><cites>FETCH-LOGICAL-c402t-5a76fca0361ce89e9cab30cfca4d924a93428adb1643fff5d81ab33edc97a43d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00701-009-0540-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00701-009-0540-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19841856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koktekir, Ender</creatorcontrib><creatorcontrib>Erdem, Yavuz</creatorcontrib><creatorcontrib>Akif Bayar, Mehmet</creatorcontrib><creatorcontrib>Gokcek, Cevdet</creatorcontrib><creatorcontrib>Karatay, Mete</creatorcontrib><creatorcontrib>Kilic, Celal</creatorcontrib><title>A new approach to the treatment of cerebral vasospasm: the angiographic effects of tadalafil on experimental vasospasm</title><title>Acta neurochirurgica</title><addtitle>Acta Neurochir</addtitle><addtitle>Acta Neurochir (Wien)</addtitle><description>Background
The pathogenesis of cerebral vasospasm is likely to be multifactorial. Strong evidence has indicated that decreasing levels of NO after SAH seem to be important. A PDE-V inhibitor, tadalafil, theoretically increases NO levels. Our study investigated the vasodilatory efficacy of tadalafil on the cerebral arteries with measurement of basilar artery diameters on angiography.
Methods
We used 42 male Wistar-Albino rats to test our hypothesis. They were assigned randomly into the following seven groups: group 1: control (only saline), group 2: SAH only (killed on day 2), group 3: SAH + tadalafil (killed on day 2), group 4: SAH only (killed on day 4), group 5: SAH + tadalafil (killed on day 4), group 6: saline + tadalafil (killed on day 2) and group 7: saline + tadalafil (killed on day 4). The three different parts of basilar artery diameters were measured angiographically.
Results
There were statistically significant differences between the SAH and SAH groups treated with tadalafil at days 2 and 4. Comparison between control and tadalafil groups showed no significant differences. This result indicated that tadalafil has a vasodilatory effect on vasoconstricted arteries, but no effect on normal basilar arteries.
Conclusion
Our study results showed that tadalafil has a vasodilatory effect on both acute and chronic periods of cerebral vasospasm. We also concluded that cerebral angiography can be used safely for investigation of cerebral vasospasm in animal studies.</description><subject>Animals</subject><subject>Basilar Artery - diagnostic imaging</subject><subject>Basilar Artery - drug effects</subject><subject>Basilar Artery - physiopathology</subject><subject>Carbolines - pharmacology</subject><subject>Carbolines - therapeutic use</subject><subject>Cerebral Angiography</subject><subject>Cerebral Arteries - diagnostic imaging</subject><subject>Cerebral Arteries - drug effects</subject><subject>Cerebral Arteries - physiopathology</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cyclic GMP - agonists</subject><subject>Cyclic GMP - metabolism</subject><subject>Disease Models, Animal</subject><subject>Drug Administration Schedule</subject><subject>Experimental Research</subject><subject>Interventional Radiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Minimally Invasive Surgery</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Nitric Oxide - agonists</subject><subject>Nitric Oxide - metabolism</subject><subject>Phosphodiesterase Inhibitors - pharmacology</subject><subject>Phosphodiesterase Inhibitors - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Subarachnoid Hemorrhage - complications</subject><subject>Surgical Orthopedics</subject><subject>Tadalafil</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vasodilator Agents - therapeutic use</subject><subject>Vasospasm, Intracranial - diagnostic imaging</subject><subject>Vasospasm, Intracranial - drug therapy</subject><subject>Vasospasm, Intracranial - physiopathology</subject><issn>0001-6268</issn><issn>0942-0940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkclqHDEQhkVIiJfkAXIJIpecOtHWi3wzJnYMhlySs6hRl2ba9LTaksaevL1rPAMOBhMdSkt99Yuqn7FPUnyTQrTfMwUhKyFsJWojqu0bdiysURUF8ZbOgrKNarojdpLzLd1Ua_R7diRtZ2RXN8fs_pxP-MBhnlMEv-Il8rJCXhJCWeNUeAzcY8JFgpHfQ455hrw-e4JgWg5xmWBeDZ5jCOhL3vEFehghDCOPE8ftjGnYSf0r8IG9CzBm_HjYT9mfyx-_L35WN7-uri_ObypvhCpVDW0TPAjdSI-dRethoYWnJ9NbZcBqozroF7IxOoRQ950kQGPvbQtG9_qUfd3rUnt3G8zFrYfscRxhwrjJrq1NTcuY_5NaK6uUbon88oK8jZs0URtOaRp5a5UkSO4hn2LOCYObaQqQ_jop3M48tzfPkXluZ57bUs3ng_Bmscb-ueLgFgFqD2RKTUtMzz-_rvoImvqm1g</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Koktekir, Ender</creator><creator>Erdem, Yavuz</creator><creator>Akif Bayar, Mehmet</creator><creator>Gokcek, Cevdet</creator><creator>Karatay, Mete</creator><creator>Kilic, Celal</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>A new approach to the treatment of cerebral vasospasm: the angiographic effects of tadalafil on experimental vasospasm</title><author>Koktekir, Ender ; Erdem, Yavuz ; Akif Bayar, Mehmet ; Gokcek, Cevdet ; Karatay, Mete ; Kilic, Celal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-5a76fca0361ce89e9cab30cfca4d924a93428adb1643fff5d81ab33edc97a43d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Basilar Artery - diagnostic imaging</topic><topic>Basilar Artery - drug effects</topic><topic>Basilar Artery - physiopathology</topic><topic>Carbolines - pharmacology</topic><topic>Carbolines - therapeutic use</topic><topic>Cerebral Angiography</topic><topic>Cerebral Arteries - diagnostic imaging</topic><topic>Cerebral Arteries - drug effects</topic><topic>Cerebral Arteries - physiopathology</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Cyclic GMP - agonists</topic><topic>Cyclic GMP - metabolism</topic><topic>Disease Models, Animal</topic><topic>Drug Administration Schedule</topic><topic>Experimental Research</topic><topic>Interventional Radiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Minimally Invasive Surgery</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Nitric Oxide - agonists</topic><topic>Nitric Oxide - metabolism</topic><topic>Phosphodiesterase Inhibitors - pharmacology</topic><topic>Phosphodiesterase Inhibitors - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Subarachnoid Hemorrhage - complications</topic><topic>Surgical Orthopedics</topic><topic>Tadalafil</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vasodilator Agents - therapeutic use</topic><topic>Vasospasm, Intracranial - diagnostic imaging</topic><topic>Vasospasm, Intracranial - drug therapy</topic><topic>Vasospasm, Intracranial - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koktekir, Ender</creatorcontrib><creatorcontrib>Erdem, Yavuz</creatorcontrib><creatorcontrib>Akif Bayar, Mehmet</creatorcontrib><creatorcontrib>Gokcek, Cevdet</creatorcontrib><creatorcontrib>Karatay, Mete</creatorcontrib><creatorcontrib>Kilic, Celal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurochirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koktekir, Ender</au><au>Erdem, Yavuz</au><au>Akif Bayar, Mehmet</au><au>Gokcek, Cevdet</au><au>Karatay, Mete</au><au>Kilic, Celal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new approach to the treatment of cerebral vasospasm: the angiographic effects of tadalafil on experimental vasospasm</atitle><jtitle>Acta neurochirurgica</jtitle><stitle>Acta Neurochir</stitle><addtitle>Acta Neurochir (Wien)</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>152</volume><issue>3</issue><spage>463</spage><epage>469</epage><pages>463-469</pages><issn>0001-6268</issn><eissn>0942-0940</eissn><abstract>Background
The pathogenesis of cerebral vasospasm is likely to be multifactorial. Strong evidence has indicated that decreasing levels of NO after SAH seem to be important. A PDE-V inhibitor, tadalafil, theoretically increases NO levels. Our study investigated the vasodilatory efficacy of tadalafil on the cerebral arteries with measurement of basilar artery diameters on angiography.
Methods
We used 42 male Wistar-Albino rats to test our hypothesis. They were assigned randomly into the following seven groups: group 1: control (only saline), group 2: SAH only (killed on day 2), group 3: SAH + tadalafil (killed on day 2), group 4: SAH only (killed on day 4), group 5: SAH + tadalafil (killed on day 4), group 6: saline + tadalafil (killed on day 2) and group 7: saline + tadalafil (killed on day 4). The three different parts of basilar artery diameters were measured angiographically.
Results
There were statistically significant differences between the SAH and SAH groups treated with tadalafil at days 2 and 4. Comparison between control and tadalafil groups showed no significant differences. This result indicated that tadalafil has a vasodilatory effect on vasoconstricted arteries, but no effect on normal basilar arteries.
Conclusion
Our study results showed that tadalafil has a vasodilatory effect on both acute and chronic periods of cerebral vasospasm. We also concluded that cerebral angiography can be used safely for investigation of cerebral vasospasm in animal studies.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>19841856</pmid><doi>10.1007/s00701-009-0540-x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Acta neurochirurgica, 2010-03, Vol.152 (3), p.463-469 |
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| subjects | Animals Basilar Artery - diagnostic imaging Basilar Artery - drug effects Basilar Artery - physiopathology Carbolines - pharmacology Carbolines - therapeutic use Cerebral Angiography Cerebral Arteries - diagnostic imaging Cerebral Arteries - drug effects Cerebral Arteries - physiopathology Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Cyclic GMP - agonists Cyclic GMP - metabolism Disease Models, Animal Drug Administration Schedule Experimental Research Interventional Radiology Male Medicine Medicine & Public Health Minimally Invasive Surgery Neurology Neuroradiology Neurosurgery Nitric Oxide - agonists Nitric Oxide - metabolism Phosphodiesterase Inhibitors - pharmacology Phosphodiesterase Inhibitors - therapeutic use Rats Rats, Wistar Subarachnoid Hemorrhage - complications Surgical Orthopedics Tadalafil Time Factors Treatment Outcome Vasodilation - drug effects Vasodilation - physiology Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use Vasospasm, Intracranial - diagnostic imaging Vasospasm, Intracranial - drug therapy Vasospasm, Intracranial - physiopathology |
| title | A new approach to the treatment of cerebral vasospasm: the angiographic effects of tadalafil on experimental vasospasm |
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