A modified technique for using elastase to create saccular aneurysms in animals that histologically and hemodynamically resemble aneurysms in human

Treatment of intracranial aneurysms is evolving with the development of novel therapies. It is important to have an animal model which simulates human aneurysms. We describe a new modified technique to the elastase aneurysm model which creates aneurysms that histologically and hemodynamically resemb...

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Veröffentlicht in:	Acta neurochirurgica 2004-07, Vol.146 (7), p.705-711
Hauptverfasser:	Hoh, B L, Rabinov, J D, Pryor, J C, Ogilvy, C S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneurysms Animals Carotid Artery, Common - drug effects Carotid Artery, Common - physiopathology Carotid Artery, Common - surgery Disease Models, Animal Female Infusions, Intra-Arterial Intracranial Aneurysm - chemically induced Intracranial Aneurysm - pathology Intracranial Aneurysm - physiopathology Ligation Medical imaging Pancreatic Elastase - administration & dosage Rabbits Regional Blood Flow
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