A study of possible correlation between subarachnoid haemorrhage related vasospasm and the post-bleed blood platelet count chart in a Caucasian population
There has been controversy about the aetiology and pathophysiology of subarachnoid haemorrhage (SAH) related vasospasm. Several pathogenic factors like endothelin and adhesion molecules have been discussed. A recently published study concerning an exclusively Asian population suggested a relationshi...
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| Veröffentlicht in: | Acta neurochirurgica 2007-04, Vol.149 (4), p.387-391 |
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| creator | Schebesch, K-M Woertgen, C Brawanski, A Rothoerl, R D |
| description | There has been controversy about the aetiology and pathophysiology of subarachnoid haemorrhage (SAH) related vasospasm. Several pathogenic factors like endothelin and adhesion molecules have been discussed. A recently published study concerning an exclusively Asian population suggested a relationship between SAH related vasospasm and the blood platelet count. The aim of our study was to examine this relationship in a European population.
We carefully reviewed 88 patients with aneurysmal SAH (54 females, 34 males; mean age 52.5 years, range from 22 to 78 years) treated in our centre with regard to the occurrence of vasospasm and the blood platelet count in a ten day interval after initial SAH. Symptomatic vasospasm was defined as a focal neurological deficit or deterioration in the level of consciousness with or without confirmation of infarction on a CT scan. Thirty-seven patients (42%) developed clinically relevant vasospasm.
There was no statistically significant correlation between the blood platelet count chart (maximum and minimum values) and vasospasm or clinical outcome; we also found no gender or age-related influence on the above mentioned relationships.
In our opinion there appears to be a difference between Caucasian and Asian populations regarding the influence of platelets in the pathophysiology of SAH and vasospasm. |
| doi_str_mv | 10.1007/s00701-007-1124-2 |
| format | Article |
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We carefully reviewed 88 patients with aneurysmal SAH (54 females, 34 males; mean age 52.5 years, range from 22 to 78 years) treated in our centre with regard to the occurrence of vasospasm and the blood platelet count in a ten day interval after initial SAH. Symptomatic vasospasm was defined as a focal neurological deficit or deterioration in the level of consciousness with or without confirmation of infarction on a CT scan. Thirty-seven patients (42%) developed clinically relevant vasospasm.
There was no statistically significant correlation between the blood platelet count chart (maximum and minimum values) and vasospasm or clinical outcome; we also found no gender or age-related influence on the above mentioned relationships.
In our opinion there appears to be a difference between Caucasian and Asian populations regarding the influence of platelets in the pathophysiology of SAH and vasospasm.</description><identifier>ISSN: 0001-6268</identifier><identifier>EISSN: 0942-0940</identifier><identifier>DOI: 10.1007/s00701-007-1124-2</identifier><identifier>PMID: 17380249</identifier><language>eng</language><publisher>Austria: Springer Nature B.V</publisher><subject>Adult ; Age Factors ; Aged ; Aneurysms ; Asian Continental Ancestry Group ; Blood Coagulation - physiology ; Blood Platelets - physiology ; Brain Infarction - etiology ; Brain Infarction - physiopathology ; European Continental Ancestry Group ; Female ; Humans ; Intracranial Aneurysm - complications ; Intracranial Aneurysm - physiopathology ; Male ; Medical treatment ; Middle Aged ; Platelet Count ; Sex Factors ; Subarachnoid Hemorrhage - blood ; Subarachnoid Hemorrhage - complications ; Subarachnoid Hemorrhage - physiopathology ; Vasospasm, Intracranial - blood ; Vasospasm, Intracranial - etiology ; Vasospasm, Intracranial - physiopathology</subject><ispartof>Acta neurochirurgica, 2007-04, Vol.149 (4), p.387-391</ispartof><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-defd6c74d46e0b4b979cf3032cefe2178ff33e82ebdb162671c11dc56c9952663</citedby><cites>FETCH-LOGICAL-c358t-defd6c74d46e0b4b979cf3032cefe2178ff33e82ebdb162671c11dc56c9952663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17380249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schebesch, K-M</creatorcontrib><creatorcontrib>Woertgen, C</creatorcontrib><creatorcontrib>Brawanski, A</creatorcontrib><creatorcontrib>Rothoerl, R D</creatorcontrib><title>A study of possible correlation between subarachnoid haemorrhage related vasospasm and the post-bleed blood platelet count chart in a Caucasian population</title><title>Acta neurochirurgica</title><addtitle>Acta Neurochir (Wien)</addtitle><description>There has been controversy about the aetiology and pathophysiology of subarachnoid haemorrhage (SAH) related vasospasm. Several pathogenic factors like endothelin and adhesion molecules have been discussed. A recently published study concerning an exclusively Asian population suggested a relationship between SAH related vasospasm and the blood platelet count. The aim of our study was to examine this relationship in a European population.
We carefully reviewed 88 patients with aneurysmal SAH (54 females, 34 males; mean age 52.5 years, range from 22 to 78 years) treated in our centre with regard to the occurrence of vasospasm and the blood platelet count in a ten day interval after initial SAH. Symptomatic vasospasm was defined as a focal neurological deficit or deterioration in the level of consciousness with or without confirmation of infarction on a CT scan. Thirty-seven patients (42%) developed clinically relevant vasospasm.
There was no statistically significant correlation between the blood platelet count chart (maximum and minimum values) and vasospasm or clinical outcome; we also found no gender or age-related influence on the above mentioned relationships.
In our opinion there appears to be a difference between Caucasian and Asian populations regarding the influence of platelets in the pathophysiology of SAH and vasospasm.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aneurysms</subject><subject>Asian Continental Ancestry Group</subject><subject>Blood Coagulation - physiology</subject><subject>Blood Platelets - physiology</subject><subject>Brain Infarction - etiology</subject><subject>Brain Infarction - physiopathology</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Humans</subject><subject>Intracranial Aneurysm - complications</subject><subject>Intracranial Aneurysm - physiopathology</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Platelet Count</subject><subject>Sex Factors</subject><subject>Subarachnoid Hemorrhage - blood</subject><subject>Subarachnoid Hemorrhage - complications</subject><subject>Subarachnoid Hemorrhage - physiopathology</subject><subject>Vasospasm, Intracranial - blood</subject><subject>Vasospasm, Intracranial - etiology</subject><subject>Vasospasm, Intracranial - physiopathology</subject><issn>0001-6268</issn><issn>0942-0940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctu1TAQhi1ERUvhAdggiwWsAr7ltqyOuEmV2LTryJcJSZXYwReqvgpP20nPkZBYsPlta775R56fkDecfeSMtZ8SCuMVasW5UJV4Ri5Yr0SFwp7jnWG1EU13Tl6mdIcv0Sr5gpzzVnZMqP6C_LmiKRf3QMNIt5DSbBagNsQIi85z8NRAvgfwNBWjo7aTD7Ojk4YVmUn_BPpEgqO_dQpp02ml2juaJ9j9coV-WDRLCI5uO7lAxgHFo046Zjp7qulBF6vTrD02beU4-hU5G_WS4PXpvCS3Xz7fHL5V1z--fj9cXVdW1l2uHIyusa1yqgFmlOnb3o6SSWFhBMHbbhylhE6AcYbjMlpuOXe2bmzf16Jp5CX5cPTdYvhVIOVhnZOFZdEeQklDW6u6xlEMyff_J5ls0HC3fPcPeBdK9PgLdKsZU_0TxI-Qjbj4COOwxXnV8WHgbNjzHY75Dvt1z3cQ2PP2ZFzMCu5vxylQ-Qg_mKNn</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Schebesch, K-M</creator><creator>Woertgen, C</creator><creator>Brawanski, A</creator><creator>Rothoerl, R D</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>A study of possible correlation between subarachnoid haemorrhage related vasospasm and the post-bleed blood platelet count chart in a Caucasian population</title><author>Schebesch, K-M ; Woertgen, C ; Brawanski, A ; Rothoerl, R D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-defd6c74d46e0b4b979cf3032cefe2178ff33e82ebdb162671c11dc56c9952663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aneurysms</topic><topic>Asian Continental Ancestry Group</topic><topic>Blood Coagulation - physiology</topic><topic>Blood Platelets - physiology</topic><topic>Brain Infarction - etiology</topic><topic>Brain Infarction - physiopathology</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Humans</topic><topic>Intracranial Aneurysm - complications</topic><topic>Intracranial Aneurysm - physiopathology</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Platelet Count</topic><topic>Sex Factors</topic><topic>Subarachnoid Hemorrhage - blood</topic><topic>Subarachnoid Hemorrhage - complications</topic><topic>Subarachnoid Hemorrhage - physiopathology</topic><topic>Vasospasm, Intracranial - blood</topic><topic>Vasospasm, Intracranial - etiology</topic><topic>Vasospasm, Intracranial - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schebesch, K-M</creatorcontrib><creatorcontrib>Woertgen, C</creatorcontrib><creatorcontrib>Brawanski, A</creatorcontrib><creatorcontrib>Rothoerl, R D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurochirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schebesch, K-M</au><au>Woertgen, C</au><au>Brawanski, A</au><au>Rothoerl, R D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study of possible correlation between subarachnoid haemorrhage related vasospasm and the post-bleed blood platelet count chart in a Caucasian population</atitle><jtitle>Acta neurochirurgica</jtitle><addtitle>Acta Neurochir (Wien)</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>149</volume><issue>4</issue><spage>387</spage><epage>391</epage><pages>387-391</pages><issn>0001-6268</issn><eissn>0942-0940</eissn><abstract>There has been controversy about the aetiology and pathophysiology of subarachnoid haemorrhage (SAH) related vasospasm. Several pathogenic factors like endothelin and adhesion molecules have been discussed. A recently published study concerning an exclusively Asian population suggested a relationship between SAH related vasospasm and the blood platelet count. The aim of our study was to examine this relationship in a European population.
We carefully reviewed 88 patients with aneurysmal SAH (54 females, 34 males; mean age 52.5 years, range from 22 to 78 years) treated in our centre with regard to the occurrence of vasospasm and the blood platelet count in a ten day interval after initial SAH. Symptomatic vasospasm was defined as a focal neurological deficit or deterioration in the level of consciousness with or without confirmation of infarction on a CT scan. Thirty-seven patients (42%) developed clinically relevant vasospasm.
There was no statistically significant correlation between the blood platelet count chart (maximum and minimum values) and vasospasm or clinical outcome; we also found no gender or age-related influence on the above mentioned relationships.
In our opinion there appears to be a difference between Caucasian and Asian populations regarding the influence of platelets in the pathophysiology of SAH and vasospasm.</abstract><cop>Austria</cop><pub>Springer Nature B.V</pub><pmid>17380249</pmid><doi>10.1007/s00701-007-1124-2</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Aneurysms Asian Continental Ancestry Group Blood Coagulation - physiology Blood Platelets - physiology Brain Infarction - etiology Brain Infarction - physiopathology European Continental Ancestry Group Female Humans Intracranial Aneurysm - complications Intracranial Aneurysm - physiopathology Male Medical treatment Middle Aged Platelet Count Sex Factors Subarachnoid Hemorrhage - blood Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - physiopathology Vasospasm, Intracranial - blood Vasospasm, Intracranial - etiology Vasospasm, Intracranial - physiopathology |
| title | A study of possible correlation between subarachnoid haemorrhage related vasospasm and the post-bleed blood platelet count chart in a Caucasian population |
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