Effect of levodopa priming on dopamine neuron transplant efficacy and induction of abnormal involuntary movements in parkinsonian rats

Clinical trials of neural grafting for Parkinson's disease (PD) have produced variable, but overall disappointing, results. One particular disappointment has been the development of aberrant motor complications following dopamine (DA) neuron grafting. Despite a lack of consistent benefit, the u...

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Veröffentlicht in:	Journal of comparative neurology (1911) 2009-07, Vol.515 (1), p.15-30
Hauptverfasser:	Steece-Collier, Kathy, Soderstrom, Katherine E., Collier, Timothy J., Sortwell, Caryl E., Maries-Lad, Eleonora
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiparkinson Agents - adverse effects Brain - drug effects Brain - metabolism Brain - physiopathology Brain Tissue Transplantation - methods Disease Models, Animal Dopamine - deficiency Drug Administration Schedule Dyskinesia, Drug-Induced - physiopathology dyskinesias Graft Survival - drug effects Graft Survival - physiology grafting levodopa Levodopa - adverse effects Male Neurons - drug effects Neurons - metabolism Neurons - transplantation Parkinson's disease Parkinsonian Disorders - drug therapy Parkinsonian Disorders - surgery priming Rats Rats, Inbred F344 rodent Treatment Outcome
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