Development of liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry for analysis of halogenated flame retardants in wastewater
Until recently, atmospheric pressure photoionization (APPI) has typically been used for the determination of non-polar halogenated flame retardants (HFRs) by liquid chromatography (LC) tandem mass spectrometry. In this study, we demonstrated the feasibility of utilizing liquid chromatography atmosph...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2010-02, Vol.396 (3), p.1311-1320 |
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| creator | Zhou, Simon Ningsun Reiner, Eric J. Marvin, Chris Helm, Paul Riddell, Nicole Dorman, Frank Misselwitz, Michelle Shen, Li Crozier, Patrick MacPherson, Karen Brindle, Ian D. |
| description | Until recently, atmospheric pressure photoionization (APPI) has typically been used for the determination of non-polar halogenated flame retardants (HFRs) by liquid chromatography (LC) tandem mass spectrometry. In this study, we demonstrated the feasibility of utilizing liquid chromatography atmospheric pressure chemical ionization (APCI) tandem mass spectrometry (LC-APCI-MS/MS) for analysis of 38 HFRs. This developed method offered three advantages: simplicity, rapidity, and high sensitivity. Compared with APPI, APCI does not require a UV lamp and a dopant reagent to assist atmospheric pressure ionization. All the isomers and the isobaric compounds were well resolved within 14-min LC separation time. Excellent instrument detection limits (6.1 pg on average with 2.0 μL injection) were observed. The APCI mechanism was also investigated. The method developed has been applied to the screening of wastewater samples for screening purpose, with concentrations determined by LC-APCI-MS/MS agreeing with data obtained via gas chromatography high resolution mass spectrometry.
Figure
LC-APCI-MS/MS for analysis of halogenated flame reterdants |
| doi_str_mv | 10.1007/s00216-009-3279-6 |
| format | Article |
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Figure
LC-APCI-MS/MS for analysis of halogenated flame reterdants</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-009-3279-6</identifier><identifier>PMID: 19957077</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Analysis methods ; Analytical Chemistry ; Applied sciences ; Atmospheric pressure ; Barometric pressure ; Biochemistry ; Characterization and Evaluation of Materials ; Chemical properties ; Chemistry ; Chemistry and Materials Science ; Chromatographic methods and physical methods associated with chromatography ; Comparative analysis ; Exact sciences and technology ; Fireproofing agents ; Flame retardants ; Food Science ; General, instrumentation ; Halogenated ; Ionization ; Laboratory Medicine ; Liquid chromatography ; Mass spectrometry ; Monitoring/Environmental Analysis ; Natural water pollution ; Original Paper ; Other chromatographic methods ; Photoionization ; Pollution ; Spectrometric and optical methods ; Spectrum analysis ; Waste water ; Wastewater ; Water treatment and pollution</subject><ispartof>Analytical and bioanalytical chemistry, 2010-02, Vol.396 (3), p.1311-1320</ispartof><rights>Springer-Verlag 2009</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c616t-41024b99a8006dd558c45887816d85636a9a62c9093a63e7df0ec557832439363</citedby><cites>FETCH-LOGICAL-c616t-41024b99a8006dd558c45887816d85636a9a62c9093a63e7df0ec557832439363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-009-3279-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-009-3279-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22598936$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19957077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Simon Ningsun</creatorcontrib><creatorcontrib>Reiner, Eric J.</creatorcontrib><creatorcontrib>Marvin, Chris</creatorcontrib><creatorcontrib>Helm, Paul</creatorcontrib><creatorcontrib>Riddell, Nicole</creatorcontrib><creatorcontrib>Dorman, Frank</creatorcontrib><creatorcontrib>Misselwitz, Michelle</creatorcontrib><creatorcontrib>Shen, Li</creatorcontrib><creatorcontrib>Crozier, Patrick</creatorcontrib><creatorcontrib>MacPherson, Karen</creatorcontrib><creatorcontrib>Brindle, Ian D.</creatorcontrib><title>Development of liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry for analysis of halogenated flame retardants in wastewater</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Until recently, atmospheric pressure photoionization (APPI) has typically been used for the determination of non-polar halogenated flame retardants (HFRs) by liquid chromatography (LC) tandem mass spectrometry. In this study, we demonstrated the feasibility of utilizing liquid chromatography atmospheric pressure chemical ionization (APCI) tandem mass spectrometry (LC-APCI-MS/MS) for analysis of 38 HFRs. This developed method offered three advantages: simplicity, rapidity, and high sensitivity. Compared with APPI, APCI does not require a UV lamp and a dopant reagent to assist atmospheric pressure ionization. All the isomers and the isobaric compounds were well resolved within 14-min LC separation time. Excellent instrument detection limits (6.1 pg on average with 2.0 μL injection) were observed. The APCI mechanism was also investigated. The method developed has been applied to the screening of wastewater samples for screening purpose, with concentrations determined by LC-APCI-MS/MS agreeing with data obtained via gas chromatography high resolution mass spectrometry.
Figure
LC-APCI-MS/MS for analysis of halogenated flame reterdants</description><subject>Analysis methods</subject><subject>Analytical Chemistry</subject><subject>Applied sciences</subject><subject>Atmospheric pressure</subject><subject>Barometric pressure</subject><subject>Biochemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Comparative analysis</subject><subject>Exact sciences and technology</subject><subject>Fireproofing agents</subject><subject>Flame retardants</subject><subject>Food Science</subject><subject>General, instrumentation</subject><subject>Halogenated</subject><subject>Ionization</subject><subject>Laboratory Medicine</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Monitoring/Environmental Analysis</subject><subject>Natural water pollution</subject><subject>Original Paper</subject><subject>Other chromatographic methods</subject><subject>Photoionization</subject><subject>Pollution</subject><subject>Spectrometric and optical methods</subject><subject>Spectrum analysis</subject><subject>Waste water</subject><subject>Wastewater</subject><subject>Water treatment and pollution</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNkstu1TAQhiMEoqXwAGyQNwg2Kb7EdrysylWqxAbW0dSZnOMqsVPbaXV4G94URzkqu6ryYizPNxfP_FX1ltFzRqn-lCjlTNWUmlpwbWr1rDplirU1V5I-f7g3_KR6ldINpUy2TL2sTpgxUlOtT6u_n_EOxzBP6DMJAxnd7eJ6YvcxTJDDLsK8PxDIU0jzHqOzZI6Y0hKxMDg5CyNxwbs_kIshGXyPE5kgJZJmtLmkwRwPZAiRgIfxkFxa6-xhDDv0kLEnwwgTkogZYg8-J-I8uYeU8b644-vqxQBjwjdHe1b9_vrl1-X3-urntx-XF1e1VUzlumGUN9fGQEup6nspW9vIttXlw30rlVBgQHFrqBGgBOp-oGil1K3gjTBCibPqw5Z3juF2wZS7ySWL4wgew5I6LRspeSObJ5BCGcX0E0ghFC_rY4X8-ChZsjWaUdW0BT3f0B2M2Dk_hBzBltOv-wgeB1feLxoqqKS81SWAbQE2hpQiDt0c3QTx0DHarULqNiF1pZNuFVK3TuPdsZ_lesL-f8RROQV4fwQgFREMEbx16YHjXJp2GyvfuFRcfoexuwlLLEpIj1T_B1f94jM</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Zhou, Simon Ningsun</creator><creator>Reiner, Eric J.</creator><creator>Marvin, Chris</creator><creator>Helm, Paul</creator><creator>Riddell, Nicole</creator><creator>Dorman, Frank</creator><creator>Misselwitz, Michelle</creator><creator>Shen, Li</creator><creator>Crozier, Patrick</creator><creator>MacPherson, Karen</creator><creator>Brindle, Ian D.</creator><general>Springer-Verlag</general><general>Springer</general><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7SU</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>7QH</scope><scope>7UA</scope></search><sort><creationdate>20100201</creationdate><title>Development of liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry for analysis of halogenated flame retardants in wastewater</title><author>Zhou, Simon Ningsun ; 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In this study, we demonstrated the feasibility of utilizing liquid chromatography atmospheric pressure chemical ionization (APCI) tandem mass spectrometry (LC-APCI-MS/MS) for analysis of 38 HFRs. This developed method offered three advantages: simplicity, rapidity, and high sensitivity. Compared with APPI, APCI does not require a UV lamp and a dopant reagent to assist atmospheric pressure ionization. All the isomers and the isobaric compounds were well resolved within 14-min LC separation time. Excellent instrument detection limits (6.1 pg on average with 2.0 μL injection) were observed. The APCI mechanism was also investigated. The method developed has been applied to the screening of wastewater samples for screening purpose, with concentrations determined by LC-APCI-MS/MS agreeing with data obtained via gas chromatography high resolution mass spectrometry.
Figure
LC-APCI-MS/MS for analysis of halogenated flame reterdants</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19957077</pmid><doi>10.1007/s00216-009-3279-6</doi><tpages>10</tpages></addata></record> |
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| ispartof | Analytical and bioanalytical chemistry, 2010-02, Vol.396 (3), p.1311-1320 |
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| subjects | Analysis methods Analytical Chemistry Applied sciences Atmospheric pressure Barometric pressure Biochemistry Characterization and Evaluation of Materials Chemical properties Chemistry Chemistry and Materials Science Chromatographic methods and physical methods associated with chromatography Comparative analysis Exact sciences and technology Fireproofing agents Flame retardants Food Science General, instrumentation Halogenated Ionization Laboratory Medicine Liquid chromatography Mass spectrometry Monitoring/Environmental Analysis Natural water pollution Original Paper Other chromatographic methods Photoionization Pollution Spectrometric and optical methods Spectrum analysis Waste water Wastewater Water treatment and pollution |
| title | Development of liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry for analysis of halogenated flame retardants in wastewater |
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