Unexpected In Vivo Anti-Inflammatory Activity Observed for Simple, Surface Functionalized Poly(amidoamine) Dendrimers

We report unexpected anti-inflammatory properties for naked, unmodified poly(amidoamine) (PAMAM) dendrimers bearing simple surface functionality (e.g., -NH2, -OH, etc.). This property was discovered serendipitously while studying the drug delivery features of PAMAM dendrimer−indomethacin complexes....

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Veröffentlicht in:	Biomacromolecules 2009-05, Vol.10 (5), p.1195-1202
Hauptverfasser:	Chauhan, Abhay S, Diwan, Prakash V, Jain, Narenda K, Tomalia, Donald A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Applied sciences Arthritis, Experimental - drug therapy Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Carrageenan Dendrimers - chemistry Dendrimers - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Edema - chemically induced Edema - drug therapy Exact sciences and technology Granuloma - drug therapy Inflammation - drug therapy Male Medical sciences Models, Molecular Molecular Structure Organic polymers Pharmacology. Drug treatments Physicochemistry of polymers Polyamines - chemistry Polyamines - pharmacology Properties and characterization Rats Rats, Wistar Special properties (catalyst, reagent or carrier) Surface Properties
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