Hydrophobically Modified Oligoethylenimines as Highly Efficient Transfection Agents for siRNA Delivery

RNA interference is a promising therapeutic strategy for treatment of diseases, in particular, cancer. Despite a huge number of targets identified for different cancer types, there are no effective delivery strategies available so far. Polymeric delivery vehicles are often based on large macromolecu...

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Veröffentlicht in:	Bioconjugate chemistry 2009-11, Vol.20 (11), p.2055-2061
Hauptverfasser:	Philipp, Alexander, Zhao, Xiaobin, Tarcha, Peter, Wagner, Ernst, Zintchenko, Arkadi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - chemistry Animals Aziridines - chemistry Biocompatible Materials Cancer Cell Membrane Permeability Cells Chemical compounds Drug Stability Humans Hydrophobic and Hydrophilic Interactions Molecular structure Molecular weight Nanoparticles Nanoparticles - chemistry Polymers - chemistry Polymers - pharmacokinetics Ribonucleic acid RNA RNA, Small Interfering - administration & dosage Toxicity Transfection - methods
Online-Zugang:	Volltext
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