Cellulose-Based Dual Graft Molecular Brushes as Potential Drug Nanocarriers: Stimulus-Responsive Micelles, Self-Assembled Phase Transition Behavior, and Tunable Crystalline Morphologies
Well-defined cellulose-based dual graft molecular brushes, composed of ethyl cellulose-graft-poly(N,N-dimethylaminoethyl methacrylate)-graft-poly(ε-caprolactone) (EC-g-PDMAEMA-g-PCL), have been prepared by ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Unlike othe...
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| Veröffentlicht in: | Biomacromolecules 2009-08, Vol.10 (8), p.2033-2042 |
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| container_title | Biomacromolecules |
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| creator | Yan, Qiang Yuan, Jinying Zhang, Fengbo Sui, Xiaofeng Xie, Xuming Yin, Yingwu Wang, Shanfeng Wei, Yen |
| description | Well-defined cellulose-based dual graft molecular brushes, composed of ethyl cellulose-graft-poly(N,N-dimethylaminoethyl methacrylate)-graft-poly(ε-caprolactone) (EC-g-PDMAEMA-g-PCL), have been prepared by ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Unlike other brush copolymers, the new molecular brushes show some unique physicochemical properties and multifunction due to their unique topological structures. These biocompatible copolymers self-assembled to micelles in aqueous solution. Upon pH change, the single micelles further assembled into micellar aggregates. As a result, the micelles in aqueous media could act as excellent drug nanocarriers for controlled drug release. The crystallinity and crystal morphology of the copolymers can be controlled to a certain extent by varying the length of the side chains, which may exert strong spacial restriction and, hence, affect the crystal structures. |
| doi_str_mv | 10.1021/bm801313q |
| format | Article |
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Unlike other brush copolymers, the new molecular brushes show some unique physicochemical properties and multifunction due to their unique topological structures. These biocompatible copolymers self-assembled to micelles in aqueous solution. Upon pH change, the single micelles further assembled into micellar aggregates. As a result, the micelles in aqueous media could act as excellent drug nanocarriers for controlled drug release. The crystallinity and crystal morphology of the copolymers can be controlled to a certain extent by varying the length of the side chains, which may exert strong spacial restriction and, hence, affect the crystal structures.</description><identifier>ISSN: 1525-7797</identifier><identifier>EISSN: 1526-4602</identifier><identifier>DOI: 10.1021/bm801313q</identifier><identifier>PMID: 19624155</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Antineoplastic Agents, Alkylating - chemistry ; Applied sciences ; Biocompatible Materials - chemistry ; Biological and medical sciences ; Calorimetry, Differential Scanning ; Cellulose and derivatives ; Chlorambucil - chemistry ; Collagen - chemistry ; Drug Carriers ; Exact sciences and technology ; General pharmacology ; Lasers ; Magnetic Resonance Spectroscopy ; Medical sciences ; Membranes, Artificial ; Micelles ; Microscopy, Atomic Force ; Nanotechnology ; Natural polymers ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Phase Transition ; Physicochemistry of polymers ; Polymers - chemistry ; Spectroscopy, Fourier Transform Infrared</subject><ispartof>Biomacromolecules, 2009-08, Vol.10 (8), p.2033-2042</ispartof><rights>Copyright © 2009 American Chemical Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a375t-98d8e2efdf6ca3d73fead2c54e46b2ad69641375e882fc28af55e2d03a3e494e3</citedby><cites>FETCH-LOGICAL-a375t-98d8e2efdf6ca3d73fead2c54e46b2ad69641375e882fc28af55e2d03a3e494e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/bm801313q$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/bm801313q$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,778,782,2754,27059,27907,27908,56721,56771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22022853$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19624155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Qiang</creatorcontrib><creatorcontrib>Yuan, Jinying</creatorcontrib><creatorcontrib>Zhang, Fengbo</creatorcontrib><creatorcontrib>Sui, Xiaofeng</creatorcontrib><creatorcontrib>Xie, Xuming</creatorcontrib><creatorcontrib>Yin, Yingwu</creatorcontrib><creatorcontrib>Wang, Shanfeng</creatorcontrib><creatorcontrib>Wei, Yen</creatorcontrib><title>Cellulose-Based Dual Graft Molecular Brushes as Potential Drug Nanocarriers: Stimulus-Responsive Micelles, Self-Assembled Phase Transition Behavior, and Tunable Crystalline Morphologies</title><title>Biomacromolecules</title><addtitle>Biomacromolecules</addtitle><description>Well-defined cellulose-based dual graft molecular brushes, composed of ethyl cellulose-graft-poly(N,N-dimethylaminoethyl methacrylate)-graft-poly(ε-caprolactone) (EC-g-PDMAEMA-g-PCL), have been prepared by ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Unlike other brush copolymers, the new molecular brushes show some unique physicochemical properties and multifunction due to their unique topological structures. These biocompatible copolymers self-assembled to micelles in aqueous solution. Upon pH change, the single micelles further assembled into micellar aggregates. As a result, the micelles in aqueous media could act as excellent drug nanocarriers for controlled drug release. The crystallinity and crystal morphology of the copolymers can be controlled to a certain extent by varying the length of the side chains, which may exert strong spacial restriction and, hence, affect the crystal structures.</description><subject>Antineoplastic Agents, Alkylating - chemistry</subject><subject>Applied sciences</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biological and medical sciences</subject><subject>Calorimetry, Differential Scanning</subject><subject>Cellulose and derivatives</subject><subject>Chlorambucil - chemistry</subject><subject>Collagen - chemistry</subject><subject>Drug Carriers</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>Lasers</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Membranes, Artificial</subject><subject>Micelles</subject><subject>Microscopy, Atomic Force</subject><subject>Nanotechnology</subject><subject>Natural polymers</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Phase Transition</subject><subject>Physicochemistry of polymers</subject><subject>Polymers - chemistry</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><issn>1525-7797</issn><issn>1526-4602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0U1v1DAQBuAIgWgpHPgDyBeEkBqIv_LRW3cLBamFii7naNYZd1058dYTV-pP49_htqty4eQ5PHpfeaYo3vLqE68E_7we24pLLm-eFftci7pUdSWeP8y6bJqu2SteEV1XVdVJpV8We7yrheJa7xd_luh98oGwXADhwE4SeHYawc7sPHg0yUNki5hog8SA2EWYcZpdRicxXbEfMAUDMTqMdMQuZzcmn6j8hbQNE7lbZOfO5AqkQ3aJ3pbHRDiufW662ORCtoqQ3ezCxBa4gVsX4iGDaWCrNEF2bBnvaAbv3ZSzQtxugg9XDul18cKCJ3yzew-K31-_rJbfyrOfp9-Xx2clyEbPZdcOLQq0g60NyKGRFmEQRitU9VrAUHe14lli2wprRAtWaxRDJUGi6hTKg-LDY-42hpuENPejo_svwYQhUd9opVXbaZnlx0dpYiCKaPttdCPEu55X_f2h-qdDZftul5rWIw7_5O4yGbzfASAD3uY1GUdPTohKiPahdOfAUH8dUpzyMv5T-BdrQ6s4</recordid><startdate>20090810</startdate><enddate>20090810</enddate><creator>Yan, Qiang</creator><creator>Yuan, Jinying</creator><creator>Zhang, Fengbo</creator><creator>Sui, Xiaofeng</creator><creator>Xie, Xuming</creator><creator>Yin, Yingwu</creator><creator>Wang, Shanfeng</creator><creator>Wei, Yen</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20090810</creationdate><title>Cellulose-Based Dual Graft Molecular Brushes as Potential Drug Nanocarriers: Stimulus-Responsive Micelles, Self-Assembled Phase Transition Behavior, and Tunable Crystalline Morphologies</title><author>Yan, Qiang ; Yuan, Jinying ; Zhang, Fengbo ; Sui, Xiaofeng ; Xie, Xuming ; Yin, Yingwu ; Wang, Shanfeng ; Wei, Yen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a375t-98d8e2efdf6ca3d73fead2c54e46b2ad69641375e882fc28af55e2d03a3e494e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Antineoplastic Agents, Alkylating - chemistry</topic><topic>Applied sciences</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biological and medical sciences</topic><topic>Calorimetry, Differential Scanning</topic><topic>Cellulose and derivatives</topic><topic>Chlorambucil - chemistry</topic><topic>Collagen - chemistry</topic><topic>Drug Carriers</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>Lasers</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Membranes, Artificial</topic><topic>Micelles</topic><topic>Microscopy, Atomic Force</topic><topic>Nanotechnology</topic><topic>Natural polymers</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. 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Unlike other brush copolymers, the new molecular brushes show some unique physicochemical properties and multifunction due to their unique topological structures. These biocompatible copolymers self-assembled to micelles in aqueous solution. Upon pH change, the single micelles further assembled into micellar aggregates. As a result, the micelles in aqueous media could act as excellent drug nanocarriers for controlled drug release. The crystallinity and crystal morphology of the copolymers can be controlled to a certain extent by varying the length of the side chains, which may exert strong spacial restriction and, hence, affect the crystal structures.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>19624155</pmid><doi>10.1021/bm801313q</doi><tpages>10</tpages></addata></record> |
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| subjects | Antineoplastic Agents, Alkylating - chemistry Applied sciences Biocompatible Materials - chemistry Biological and medical sciences Calorimetry, Differential Scanning Cellulose and derivatives Chlorambucil - chemistry Collagen - chemistry Drug Carriers Exact sciences and technology General pharmacology Lasers Magnetic Resonance Spectroscopy Medical sciences Membranes, Artificial Micelles Microscopy, Atomic Force Nanotechnology Natural polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phase Transition Physicochemistry of polymers Polymers - chemistry Spectroscopy, Fourier Transform Infrared |
| title | Cellulose-Based Dual Graft Molecular Brushes as Potential Drug Nanocarriers: Stimulus-Responsive Micelles, Self-Assembled Phase Transition Behavior, and Tunable Crystalline Morphologies |
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