Hydrophobically Modified Biodegradable Poly(ethylene glycol) Copolymers that Form Temperature-Responsive Nanogels
Biodegradable copolymers consisting of a hydrophilic poly[l-aspartic acid-alt-poly(ethylene glycol)] (poly(l-Asp-alt-PEG)) backbone and hydrophobic capryl units as side chains were synthesized. The amphiphilic copolymer was found to form nanosized hydrogel particles (nanogels) of approximately 15 nm...
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| Veröffentlicht in: | Langmuir 2009-09, Vol.25 (17), p.9734-9740 |
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| creator | Nagahama, Koji Hashizume, Mihoko Yamamoto, Hidetoshi Ouchi, Tatsuro Ohya, Yuichi |
| description | Biodegradable copolymers consisting of a hydrophilic poly[l-aspartic acid-alt-poly(ethylene glycol)] (poly(l-Asp-alt-PEG)) backbone and hydrophobic capryl units as side chains were synthesized. The amphiphilic copolymer was found to form nanosized hydrogel particles (nanogels) of approximately 15 nm in size by self-assembly at 20 °C in aqueous media, and the nanogel solutions displayed phase-transition in response to temperature. The transition of the nanogel solution was reversible and tunable in the range from 19 to 55 °C by variation of the amounts of capryl units introduced and the solution concentration. The nanogels were gradually degraded within days in a phosphate buffer solution (PBS) at 37 °C. Temperature-responsive biodegradable nanogel systems consisting of biocompatible PEG may have potential utility for high biocompatibility temperature-responsive nanodevices such as microreactor systems, molecular-chaperones, and drug delivery vehicles. |
| doi_str_mv | 10.1021/la901092x |
| format | Article |
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The amphiphilic copolymer was found to form nanosized hydrogel particles (nanogels) of approximately 15 nm in size by self-assembly at 20 °C in aqueous media, and the nanogel solutions displayed phase-transition in response to temperature. The transition of the nanogel solution was reversible and tunable in the range from 19 to 55 °C by variation of the amounts of capryl units introduced and the solution concentration. The nanogels were gradually degraded within days in a phosphate buffer solution (PBS) at 37 °C. Temperature-responsive biodegradable nanogel systems consisting of biocompatible PEG may have potential utility for high biocompatibility temperature-responsive nanodevices such as microreactor systems, molecular-chaperones, and drug delivery vehicles.</description><identifier>ISSN: 0743-7463</identifier><identifier>EISSN: 1520-5827</identifier><identifier>DOI: 10.1021/la901092x</identifier><identifier>PMID: 19705882</identifier><identifier>CODEN: LANGD5</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Biocompatible Materials - chemistry ; Biodegradation, Environmental ; Chemistry ; Colloidal gels. Colloidal sols ; Colloidal state and disperse state ; Colloids: Surfactants and Self-Assembly, Dispersions, Emulsions, Foams ; Drug Carriers - chemistry ; Drug Delivery Systems ; Exact sciences and technology ; Gels - chemistry ; General and physical chemistry ; Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry ; Models, Chemical ; Nanoparticles - chemistry ; Nanotechnology - methods ; Particle Size ; Polyethylene Glycols - chemistry ; Polyethyleneimine - chemistry ; Polymers - chemistry ; Solutions ; Surface physical chemistry ; Temperature</subject><ispartof>Langmuir, 2009-09, Vol.25 (17), p.9734-9740</ispartof><rights>Copyright © 2009 American Chemical Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a375t-6ac6699ccd26cfb51b805e46663f0b48edcd3d32397a3c0a0500311a97f514683</citedby><cites>FETCH-LOGICAL-a375t-6ac6699ccd26cfb51b805e46663f0b48edcd3d32397a3c0a0500311a97f514683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/la901092x$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/la901092x$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,777,781,2752,27057,27905,27906,56719,56769</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22069767$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19705882$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagahama, Koji</creatorcontrib><creatorcontrib>Hashizume, Mihoko</creatorcontrib><creatorcontrib>Yamamoto, Hidetoshi</creatorcontrib><creatorcontrib>Ouchi, Tatsuro</creatorcontrib><creatorcontrib>Ohya, Yuichi</creatorcontrib><title>Hydrophobically Modified Biodegradable Poly(ethylene glycol) Copolymers that Form Temperature-Responsive Nanogels</title><title>Langmuir</title><addtitle>Langmuir</addtitle><description>Biodegradable copolymers consisting of a hydrophilic poly[l-aspartic acid-alt-poly(ethylene glycol)] (poly(l-Asp-alt-PEG)) backbone and hydrophobic capryl units as side chains were synthesized. The amphiphilic copolymer was found to form nanosized hydrogel particles (nanogels) of approximately 15 nm in size by self-assembly at 20 °C in aqueous media, and the nanogel solutions displayed phase-transition in response to temperature. The transition of the nanogel solution was reversible and tunable in the range from 19 to 55 °C by variation of the amounts of capryl units introduced and the solution concentration. The nanogels were gradually degraded within days in a phosphate buffer solution (PBS) at 37 °C. Temperature-responsive biodegradable nanogel systems consisting of biocompatible PEG may have potential utility for high biocompatibility temperature-responsive nanodevices such as microreactor systems, molecular-chaperones, and drug delivery vehicles.</description><subject>Biocompatible Materials - chemistry</subject><subject>Biodegradation, Environmental</subject><subject>Chemistry</subject><subject>Colloidal gels. Colloidal sols</subject><subject>Colloidal state and disperse state</subject><subject>Colloids: Surfactants and Self-Assembly, Dispersions, Emulsions, Foams</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems</subject><subject>Exact sciences and technology</subject><subject>Gels - chemistry</subject><subject>General and physical chemistry</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry</subject><subject>Models, Chemical</subject><subject>Nanoparticles - chemistry</subject><subject>Nanotechnology - methods</subject><subject>Particle Size</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethyleneimine - chemistry</subject><subject>Polymers - chemistry</subject><subject>Solutions</subject><subject>Surface physical chemistry</subject><subject>Temperature</subject><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1r3DAQgGFRWppt2kP_QNGlJDm41YclWcd2SZpC-kFJz2YsjXcdZMuR7BD_-7pkSS45DQwPM_AS8p6zT5wJ_jmAZZxZcf-CbLgSrFCVMC_JhplSFqbU8oi8yfmGMWZlaV-TI24NU1UlNuT2cvEpjvvYdA5CWOiP6Lu2Q0-_dtHjLoGHJiD9HcNyitN-CTgg3YXFxXBGt3Fc9z2mTKc9TPQipp5eYz9igmlOWPzBPMYhd3dIf8IQdxjyW_KqhZDx3WEek78X59fby-Lq17fv2y9XBUijpkKD09pa57zQrm0UbyqmsNRay5Y1ZYXeeemlkNaAdAyYYkxyDta0ipe6ksfk5OHumOLtjHmq-y47DAEGjHOujSpVWZmKr_LsQboUc07Y1mPqekhLzVn9P3D9GHi1Hw5X56ZH_yQPRVfw8QAgr0XbBIPr8qMTgmlrtHly4HJ9E-c0rDGeefgP9riQXQ</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Nagahama, Koji</creator><creator>Hashizume, Mihoko</creator><creator>Yamamoto, Hidetoshi</creator><creator>Ouchi, Tatsuro</creator><creator>Ohya, Yuichi</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20090901</creationdate><title>Hydrophobically Modified Biodegradable Poly(ethylene glycol) Copolymers that Form Temperature-Responsive Nanogels</title><author>Nagahama, Koji ; Hashizume, Mihoko ; Yamamoto, Hidetoshi ; Ouchi, Tatsuro ; Ohya, Yuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a375t-6ac6699ccd26cfb51b805e46663f0b48edcd3d32397a3c0a0500311a97f514683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biocompatible Materials - chemistry</topic><topic>Biodegradation, Environmental</topic><topic>Chemistry</topic><topic>Colloidal gels. Colloidal sols</topic><topic>Colloidal state and disperse state</topic><topic>Colloids: Surfactants and Self-Assembly, Dispersions, Emulsions, Foams</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Delivery Systems</topic><topic>Exact sciences and technology</topic><topic>Gels - chemistry</topic><topic>General and physical chemistry</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry</topic><topic>Models, Chemical</topic><topic>Nanoparticles - chemistry</topic><topic>Nanotechnology - methods</topic><topic>Particle Size</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethyleneimine - chemistry</topic><topic>Polymers - chemistry</topic><topic>Solutions</topic><topic>Surface physical chemistry</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagahama, Koji</creatorcontrib><creatorcontrib>Hashizume, Mihoko</creatorcontrib><creatorcontrib>Yamamoto, Hidetoshi</creatorcontrib><creatorcontrib>Ouchi, Tatsuro</creatorcontrib><creatorcontrib>Ohya, Yuichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagahama, Koji</au><au>Hashizume, Mihoko</au><au>Yamamoto, Hidetoshi</au><au>Ouchi, Tatsuro</au><au>Ohya, Yuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrophobically Modified Biodegradable Poly(ethylene glycol) Copolymers that Form Temperature-Responsive Nanogels</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>25</volume><issue>17</issue><spage>9734</spage><epage>9740</epage><pages>9734-9740</pages><issn>0743-7463</issn><eissn>1520-5827</eissn><coden>LANGD5</coden><abstract>Biodegradable copolymers consisting of a hydrophilic poly[l-aspartic acid-alt-poly(ethylene glycol)] (poly(l-Asp-alt-PEG)) backbone and hydrophobic capryl units as side chains were synthesized. The amphiphilic copolymer was found to form nanosized hydrogel particles (nanogels) of approximately 15 nm in size by self-assembly at 20 °C in aqueous media, and the nanogel solutions displayed phase-transition in response to temperature. The transition of the nanogel solution was reversible and tunable in the range from 19 to 55 °C by variation of the amounts of capryl units introduced and the solution concentration. The nanogels were gradually degraded within days in a phosphate buffer solution (PBS) at 37 °C. Temperature-responsive biodegradable nanogel systems consisting of biocompatible PEG may have potential utility for high biocompatibility temperature-responsive nanodevices such as microreactor systems, molecular-chaperones, and drug delivery vehicles.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>19705882</pmid><doi>10.1021/la901092x</doi><tpages>7</tpages></addata></record> |
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| subjects | Biocompatible Materials - chemistry Biodegradation, Environmental Chemistry Colloidal gels. Colloidal sols Colloidal state and disperse state Colloids: Surfactants and Self-Assembly, Dispersions, Emulsions, Foams Drug Carriers - chemistry Drug Delivery Systems Exact sciences and technology Gels - chemistry General and physical chemistry Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Models, Chemical Nanoparticles - chemistry Nanotechnology - methods Particle Size Polyethylene Glycols - chemistry Polyethyleneimine - chemistry Polymers - chemistry Solutions Surface physical chemistry Temperature |
| title | Hydrophobically Modified Biodegradable Poly(ethylene glycol) Copolymers that Form Temperature-Responsive Nanogels |
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