O-Carboxymethyl−Chitin Concentration in Granulocytes during Bone Repair
Peroral and intravenous administrations of 14C-labeled carboxymethyl−chitin (CM−chitin) revealed that CM−chitin accumulated in bone marrow. Thus, a composite of CM−chitin with hydroxyapatite (HA) was prepared to examine the bone repairing properties by animal and cell line experiments. The new bone...
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| Veröffentlicht in: | Biomacromolecules 2001, Vol.2 (2), p.417-421 |
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| creator | Tokura, Seiichi Tamura, Hiroshi |
| description | Peroral and intravenous administrations of 14C-labeled carboxymethyl−chitin (CM−chitin) revealed that CM−chitin accumulated in bone marrow. Thus, a composite of CM−chitin with hydroxyapatite (HA) was prepared to examine the bone repairing properties by animal and cell line experiments. The new bone formation of CM−chitin·HA composite was superior to that of CM−chitin, HA, and blank. A porous CM−chitin·HA composite is a functional material which could act as a scaffolding of osteoblast-like cells, a barrier to ingrowth of fibrous connective tissues. The cytotoxicity of CM−chitin was evaluated using the MC3T3-E1 cell line, and we found that control of degree of deacetylation is a very important factor in using CM−chitin as bone repairing material. |
| doi_str_mv | 10.1021/bm0001345 |
| format | Article |
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Thus, a composite of CM−chitin with hydroxyapatite (HA) was prepared to examine the bone repairing properties by animal and cell line experiments. The new bone formation of CM−chitin·HA composite was superior to that of CM−chitin, HA, and blank. A porous CM−chitin·HA composite is a functional material which could act as a scaffolding of osteoblast-like cells, a barrier to ingrowth of fibrous connective tissues. 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| subjects | Administration, Oral Animals Biocompatible Materials - pharmacokinetics Biocompatible Materials - therapeutic use Biocompatible Materials - toxicity Cell Line Cell Survival - drug effects Chitin - analogs & derivatives Chitin - pharmacokinetics Chitin - therapeutic use Chitin - toxicity Femur - pathology Granulocytes - metabolism Injections, Intravenous Macaca fascicularis Mice Osseointegration Rabbits Tissue Distribution |
| title | O-Carboxymethyl−Chitin Concentration in Granulocytes during Bone Repair |
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