Novel Zwitterionic-Polymer-Coated Silica Nanoparticles
In this work, silica nanoparticles covered with an initiator silane were grafted with novel biocompatible and functionalizable zwitterionic poly[[3-(acryloylamino)propyl](2-carboxyethyl)dimethylammonium] (polyCBAA) via atomic transfer radical polymerization. The stability of these particles in prote...
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| Veröffentlicht in: | Langmuir 2009-03, Vol.25 (5), p.3196-3199 |
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| creator | Jia, Guangwei Cao, Zhiqiang Xue, Hong Xu, Yongshen Jiang, Shaoyi |
| description | In this work, silica nanoparticles covered with an initiator silane were grafted with novel biocompatible and functionalizable zwitterionic poly[[3-(acryloylamino)propyl](2-carboxyethyl)dimethylammonium] (polyCBAA) via atomic transfer radical polymerization. The stability of these particles in protein solutions and their functionalization were investigated. Dynamic light scattering and transmission electron microscopy were employed to characterize these particles. Results indicate that the polyCBAA-modified nanoparticles are stable for at least 72 h in both negative and positive protein solutions. The size distribution remains the same before and after protein incubation. Moreover, our results show that polyCBAA-modified silica nanoparticles can be easily functionalized. This makes these particles ideal candidates for future applications in targeted drug delivery and diagnostics in complex media. |
| doi_str_mv | 10.1021/la803737c |
| format | Article |
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The stability of these particles in protein solutions and their functionalization were investigated. Dynamic light scattering and transmission electron microscopy were employed to characterize these particles. Results indicate that the polyCBAA-modified nanoparticles are stable for at least 72 h in both negative and positive protein solutions. The size distribution remains the same before and after protein incubation. Moreover, our results show that polyCBAA-modified silica nanoparticles can be easily functionalized. This makes these particles ideal candidates for future applications in targeted drug delivery and diagnostics in complex media.</description><identifier>ISSN: 0743-7463</identifier><identifier>EISSN: 1520-5827</identifier><identifier>DOI: 10.1021/la803737c</identifier><identifier>PMID: 19437722</identifier><identifier>CODEN: LANGD5</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Acrylamides - chemistry ; Adsorption ; Chemistry ; Colloidal state and disperse state ; Drug Delivery Systems ; Exact sciences and technology ; General and physical chemistry ; Light ; Materials: Nano-and Mesostructured Materials, Polymers, Gels, Liquid Crystals, Composites ; Microscopy, Electron, Transmission ; Muramidase - chemistry ; Nanoparticles - chemistry ; Nanotechnology - methods ; Physical and chemical studies. Granulometry. Electrokinetic phenomena ; Polymers - chemistry ; Proteins - chemistry ; Scattering, Radiation ; Silanes ; Silicon Dioxide - chemistry ; Surface physical chemistry ; Surface Properties ; Time Factors</subject><ispartof>Langmuir, 2009-03, Vol.25 (5), p.3196-3199</ispartof><rights>Copyright © 2009 American Chemical Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a375t-2545abecea79d46563c638ec9d8f216aad41534198704b3a893983e3de57ae8b3</citedby><cites>FETCH-LOGICAL-a375t-2545abecea79d46563c638ec9d8f216aad41534198704b3a893983e3de57ae8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/la803737c$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/la803737c$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21230589$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19437722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Guangwei</creatorcontrib><creatorcontrib>Cao, Zhiqiang</creatorcontrib><creatorcontrib>Xue, Hong</creatorcontrib><creatorcontrib>Xu, Yongshen</creatorcontrib><creatorcontrib>Jiang, Shaoyi</creatorcontrib><title>Novel Zwitterionic-Polymer-Coated Silica Nanoparticles</title><title>Langmuir</title><addtitle>Langmuir</addtitle><description>In this work, silica nanoparticles covered with an initiator silane were grafted with novel biocompatible and functionalizable zwitterionic poly[[3-(acryloylamino)propyl](2-carboxyethyl)dimethylammonium] (polyCBAA) via atomic transfer radical polymerization. The stability of these particles in protein solutions and their functionalization were investigated. Dynamic light scattering and transmission electron microscopy were employed to characterize these particles. Results indicate that the polyCBAA-modified nanoparticles are stable for at least 72 h in both negative and positive protein solutions. The size distribution remains the same before and after protein incubation. Moreover, our results show that polyCBAA-modified silica nanoparticles can be easily functionalized. This makes these particles ideal candidates for future applications in targeted drug delivery and diagnostics in complex media.</description><subject>Acrylamides - chemistry</subject><subject>Adsorption</subject><subject>Chemistry</subject><subject>Colloidal state and disperse state</subject><subject>Drug Delivery Systems</subject><subject>Exact sciences and technology</subject><subject>General and physical chemistry</subject><subject>Light</subject><subject>Materials: Nano-and Mesostructured Materials, Polymers, Gels, Liquid Crystals, Composites</subject><subject>Microscopy, Electron, Transmission</subject><subject>Muramidase - chemistry</subject><subject>Nanoparticles - chemistry</subject><subject>Nanotechnology - methods</subject><subject>Physical and chemical studies. Granulometry. Electrokinetic phenomena</subject><subject>Polymers - chemistry</subject><subject>Proteins - chemistry</subject><subject>Scattering, Radiation</subject><subject>Silanes</subject><subject>Silicon Dioxide - chemistry</subject><subject>Surface physical chemistry</subject><subject>Surface Properties</subject><subject>Time Factors</subject><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E9LAzEQBfAgitbqwS8gvah4WE0yyWZzlOI_KCqoFy_LNDuFSLqpyVbx27tiqRfxNJcf7zGPsQPBzwSX4jxgxcGAcRtsILTkha6k2WQDbhQURpWww3ZzfuWcW1B2m-0Iq8AYKQesvIvvFEYvH77rKPnYelc8xPA5p1SMI3bUjB598A5Hd9jGBabOu0B5j23NMGTaX90he766fBrfFJP769vxxaRAMLorpFYap-QIjW1UqUtwJVTkbFPNpCgRGyU0KGErw9UUsLJgKyBoSBukagpDdvKTu0jxbUm5q-c-OwoBW4rLXJu-QJnv4CE7_leWRgJYrnt4-gNdijknmtWL5OeYPmvB6-856_WcvT1chS6nc2p-5Wq_HhytAGaHYZawdT6vnRQSuO6_Wjt0uX6Ny9T2q_1R-AUzxIc_</recordid><startdate>20090303</startdate><enddate>20090303</enddate><creator>Jia, Guangwei</creator><creator>Cao, Zhiqiang</creator><creator>Xue, Hong</creator><creator>Xu, Yongshen</creator><creator>Jiang, Shaoyi</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20090303</creationdate><title>Novel Zwitterionic-Polymer-Coated Silica Nanoparticles</title><author>Jia, Guangwei ; Cao, Zhiqiang ; Xue, Hong ; Xu, Yongshen ; Jiang, Shaoyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a375t-2545abecea79d46563c638ec9d8f216aad41534198704b3a893983e3de57ae8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acrylamides - chemistry</topic><topic>Adsorption</topic><topic>Chemistry</topic><topic>Colloidal state and disperse state</topic><topic>Drug Delivery Systems</topic><topic>Exact sciences and technology</topic><topic>General and physical chemistry</topic><topic>Light</topic><topic>Materials: Nano-and Mesostructured Materials, Polymers, Gels, Liquid Crystals, Composites</topic><topic>Microscopy, Electron, Transmission</topic><topic>Muramidase - chemistry</topic><topic>Nanoparticles - chemistry</topic><topic>Nanotechnology - methods</topic><topic>Physical and chemical studies. Granulometry. Electrokinetic phenomena</topic><topic>Polymers - chemistry</topic><topic>Proteins - chemistry</topic><topic>Scattering, Radiation</topic><topic>Silanes</topic><topic>Silicon Dioxide - chemistry</topic><topic>Surface physical chemistry</topic><topic>Surface Properties</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Guangwei</creatorcontrib><creatorcontrib>Cao, Zhiqiang</creatorcontrib><creatorcontrib>Xue, Hong</creatorcontrib><creatorcontrib>Xu, Yongshen</creatorcontrib><creatorcontrib>Jiang, Shaoyi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Guangwei</au><au>Cao, Zhiqiang</au><au>Xue, Hong</au><au>Xu, Yongshen</au><au>Jiang, Shaoyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel Zwitterionic-Polymer-Coated Silica Nanoparticles</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2009-03-03</date><risdate>2009</risdate><volume>25</volume><issue>5</issue><spage>3196</spage><epage>3199</epage><pages>3196-3199</pages><issn>0743-7463</issn><eissn>1520-5827</eissn><coden>LANGD5</coden><abstract>In this work, silica nanoparticles covered with an initiator silane were grafted with novel biocompatible and functionalizable zwitterionic poly[[3-(acryloylamino)propyl](2-carboxyethyl)dimethylammonium] (polyCBAA) via atomic transfer radical polymerization. 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| subjects | Acrylamides - chemistry Adsorption Chemistry Colloidal state and disperse state Drug Delivery Systems Exact sciences and technology General and physical chemistry Light Materials: Nano-and Mesostructured Materials, Polymers, Gels, Liquid Crystals, Composites Microscopy, Electron, Transmission Muramidase - chemistry Nanoparticles - chemistry Nanotechnology - methods Physical and chemical studies. Granulometry. Electrokinetic phenomena Polymers - chemistry Proteins - chemistry Scattering, Radiation Silanes Silicon Dioxide - chemistry Surface physical chemistry Surface Properties Time Factors |
| title | Novel Zwitterionic-Polymer-Coated Silica Nanoparticles |
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