Synthesis of Sulfated Colominic Acids and Their Interaction with Fibroblast Growth Factors

Colominic acid, an α(2→8)-linked poly(sialic acid), was sulfated and characterized by NMR spectroscopy. During sulfation, the secondary hydroxyl group at C-4 had almost the same reactivity as the primary hydroxyl group at C-9, while the secondary hydroxyl group at C-7 was hardly substituted. Analysi...

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Veröffentlicht in:	Biomacromolecules 2000, Vol.1 (3), p.451-458
Hauptverfasser:	Kunou, Megumi, Koizumi, Masako, Shimizu, Kengo, Kawase, Mitsuo, Hatanaka, Kenichi
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Circular Dichroism Fibroblast Growth Factors - chemistry Magnetic Resonance Spectroscopy Mice Mitogens - chemical synthesis Mitogens - pharmacology Models, Molecular Polysaccharides - chemical synthesis Polysaccharides - chemistry Polysaccharides - pharmacology Spectrophotometry, Infrared Sulfates - chemistry
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