Cationic Lipid Polymerization as a Novel Approach for Constructing New DNA Delivery Agents

In vivo gene delivery mediated by cationic lipids is often compromised by aggregation due to complexation with proteins in the blood. To improve the stability of cationic lipid−DNA complexes, the present study aimed to develop a novel approach in which a poly(cationic lipid) (PCL) is utilized to for...

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Veröffentlicht in:	Bioconjugate chemistry 2001-03, Vol.12 (2), p.251-257
Hauptverfasser:	Wu, Jian, Lizarzaburu, Mike E, Kurth, Mark J, Liu, Li, Wege, Henning, Zern, Mark A, Nantz, Michael H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cation Exchange Resins - chemistry Cell Line Cholesterol - chemistry Drug Carriers - chemistry Fatty Acids, Monounsaturated - chemistry Fluorescent Dyes - chemistry Gene Transfer Techniques Hepatocytes - drug effects Humans Indicators and Reagents - chemistry Lipids - chemistry Liposomes - chemistry Liposomes - pharmacology Molecular Structure Particle Size Polyamines - chemistry Quaternary Ammonium Compounds - chemistry Rats Rats, Sprague-Dawley Transfection - methods
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