A Novel Antitumor Prodrug Platform Designed to Be Cleaved by the Endoprotease Legumain

Chemotherapeutic treatment of neoplastic diseases is often restricted by adverse systemic toxicity, which limits the dose of drug that can be administered, or by the appearance of drug resistance. Therefore, novel targeted therapeutic approaches are being developed to improve current conventional th...

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Veröffentlicht in:	Bioconjugate chemistry 2009-03, Vol.20 (3), p.500-510
Hauptverfasser:	Stern, Liron, Perry, Rotem, Ofek, Paula, Many, Ariel, Shabat, Doron, Satchi-Fainaro, Ronit
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Cell adhesion & migration Cell Line Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Drug resistance Drug therapy Etoposide - chemistry Etoposide - metabolism Etoposide - pharmacology Humans Liquid chromatography Male Mice Mice, Inbred BALB C Prodrugs - chemistry Prodrugs - metabolism Prodrugs - pharmacology Toxicity Tumors Up-Regulation
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