The Novel Iron Chelator, 2-Pyridylcarboxaldehyde 2-Thiophenecarboxyl Hydrazone, Reduces Catecholamine-Mediated Myocardial Toxicity

Iron (Fe) chelators are used clinically for the treatment of Fe overload disease. Iron also plays a role in the pathology of many other conditions, and these potentially include the cardiotoxicity induced by catecholamines such as isoprenaline (ISO). The current study examined the potential of Fe ch...

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Veröffentlicht in:	Chemical research in toxicology 2009-01, Vol.22 (1), p.208-217
Hauptverfasser:	Mladĕnka, Pr̆emysl, Kalinowski, Danuta S, Hašková, Pavlína, Bobrovová, Zuzana, Hrdina, Radomír, Šimůnek, Tomáš, Nachtigal, Petr, Semecký, Vladimír, Vávrová, Jaroslava, Holečková, Magdaléna, Palicka, Vladimir, Mazurová, Yvona, Jansson, Patric J, Richardson, Des R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catecholamines - antagonists & inhibitors Catecholamines - metabolism Catecholamines - toxicity Cell Line Deferoxamine - administration & dosage Iron - metabolism Iron Chelating Agents - pharmacology Isoproterenol - antagonists & inhibitors Isoproterenol - metabolism Isoproterenol - toxicity Male Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Oxidation-Reduction Rats Rats, Wistar Thiophenes - pharmacology
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