A Molecular Mimic of Phosphorylated Prolactin (S179D PRL) Secreted by Eukaryotic Cells Has a Conformation with an Increased Positive Surface Charge Compared to That of Unmodified Prolactin

S179D prolactin (S179D PRL) is a pseudophosphorylated form of human PRL which has potent antitumor and anti-angiogenic activities in vivo. This molecule binds to the same forms of the PRL receptor (PRLR) as unmodified PRL, yet this binding results in different intracellular signaling and biological...

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