Triple Helix-Forming Oligonucleotides Conjugated to Indolocarbazole Poisons Direct Topoisomerase I-Mediated DNA Cleavage to a Specific Site

Topoisomerase I is an ubiquitous DNA-cleaving enzyme and an important therapeutic target in cancer chemotherapy for camptothecins as well as for indolocarbazole antibiotics such as rebeccamycin. To achieve a sequence-specific cleavage of DNA by topoisomerase I, a triple helix-forming oligonucleotide...

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Veröffentlicht in:	Bioconjugate chemistry 2001-07, Vol.12 (4), p.501-509
Hauptverfasser:	Arimondo, Paola B, Bailly, Christian, Boutorine, Alexandre S, Moreau, Pascale, Prudhomme, Michelle, Sun, Jian-Sheng, Garestier, Thérèse, Hélène, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Base Sequence Carbazoles DNA - metabolism DNA Topoisomerases, Type I - metabolism Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Indoles Models, Molecular Oligonucleotides - chemical synthesis Oligonucleotides - metabolism Substrate Specificity Topoisomerase I Inhibitors
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