Synthesis of Monodisperse Biodegradable Microgels in Microfluidic Devices

Synthesis of Monodisperse Biodegradable Microgels in Microfluidic Devices

Microgels are promising materials in drug delivery and biomedicine. Although monodisperse microgels would offer considerable advantages, most microgels investigated and used today are polydisperse in size. We report on the fabrication of 10 μm sized monodisperse microgels by emulsifying an aqueous d...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Langmuir 2005-11, Vol.21 (23), p.10275-10279
Hauptverfasser: De Geest, Bruno G, Urbanski, John Paul, Thorsen, Todd, Demeester, Jo, De Smedt, Stefaan C
Format: Artikel
Sprache:eng
Schlagworte:
Biocompatible Materials
Chemistry
Colloidal state and disperse state
Exact sciences and technology
Gels
General and physical chemistry
Methacrylates - chemistry
Microfluidics - instrumentation
Microscopy
Physical and chemical studies. Granulometry. Electrokinetic phenomena
Ultraviolet Rays
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Microgels are promising materials in drug delivery and biomedicine. Although monodisperse microgels would offer considerable advantages, most microgels investigated and used today are polydisperse in size. We report on the fabrication of 10 μm sized monodisperse microgels by emulsifying an aqueous dextran-hydroxyethyl methacrylate (dex-HEMA) phase within an oil phase at the junction of microfluidic channels. Dex-HEMA microgels are biodegradable and are ideally suited for the controlled delivery of proteins.
ISSN:0743-7463
1520-5827
DOI:10.1021/la051527y